Results 81 to 90 of about 84,275 (265)

The Multiple Criteria Qualitative Value‐Based Pricing Framework “MARIE” for Novel Cell and Gene Therapy

Clinical Pharmacology &Therapeutics, EarlyView.
When setting the price of cell and gene therapies in Japan, the factors considered include the manufacturing and operating costs of the new drug or a comparator, leading to discrepancies between price and values, in particular those specific to cell and gene therapies.
Akina Takami, Ataru Igarashi
wiley   +1 more source

Designing Governance for ESG: Incentive and Oversight Complementarities in Corporate Sustainability Performance

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study investigates how internal governance design supports credible ESG performance by distinguishing between Incentive and Oversight Architectures. Using 13,993 firm‐year observations of US nonfinancial firms from 2018 to 2024, we estimate fixed effects and two‐step system GMM models.
Beyza Gürel, Nehir Balci, Mustafa Reha Okur   +2 more
wiley   +1 more source

Anticoagulation with Nafamostat Mesilate During Impella Support: A Case Report

Medicina
Achieving an optimal balance between thrombosis prevention and bleeding risk during temporary mechanical circulatory support remains a significant clinical challenge. Effective anticoagulation management that ensures device functionality while minimizing
Makiko Nakamura, Teruhiko Imamura, Yuki Hida, Toshihide Izumida, Masaki Nakagaito, Saori Nagura, Toshio Doi, Koichiro Kinugawa   +7 more
doaj   +1 more source

Mechanism of “seesaw‐type” rock burst in coal seam mining beneath mountainous areas

Deep Underground Science and Engineering, EarlyView.
This study reveals the mechanism of “seesaw‐type” rock bursts during coal mining beneath mountainous areas. The advancing working face induces nonuniform fracturing of the overburden. The detached mountain mass then undergoes a seesaw‐type rotational movement around a shifting pivot, driving the primary fracture through a characteristic “open‐close ...
Chao Zhou, Xueqiu He, Zhenlei Li, Ping Wang, Dazhao Song, Fuxing Jiang, Shan Yin, Anliang Lü, Menghan Wei, Taoping Zhong   +9 more
wiley   +1 more source

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

Developmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard, Lauren Clarissa Tang, Beatrix Ueberheide, Lisa A. Taneyhill   +3 more
wiley   +1 more source

Associations Between Microbial Depletion and Autonomic Dysregulation in Binge‐Eating Disorder

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective The interplay between the gut microbiome and autonomic nervous system remains unexplored in binge‐eating disorder (BED). We aimed to explore specific microbial alterations in BED and examine their potential association with cardiac vagal tone as a distinct bio‐behavioral phenotype.
Shuang Liang, Esben Strodl, Leanne Barron, Matthew Bambling, Luis Vitetta   +4 more
wiley   +1 more source

Enhanced strength and work hardening in Ti–10V–2Cu–3Al alloy associated with liquid-nitrogen-quenching-induced changes in internal twinning behavior of orthorhombic α″ martensite

Journal of Materials Research and Technology
The use of orthorhombic martensite (α″) in Ti alloys has attracted attention because of its relatively low Young's modulus, but it remains insufficiently explored as a basis for microstructural strengthening.
Shion Shimizu, Takuya Ishimoto, Tomoyo Manaka, Taiki Tsuchiya, Kenji Matsuda   +4 more
doaj   +1 more source

Climatic niche divergence and high‐elevation adaptation promoted rapid diversification of Pimoa spiders in Pan‐Himalaya

Ecography, EarlyView.
The Pan‐Himalayan region harbors exceptional biodiversity, yet the origins and underlying mechanisms driving this remarkable diversity remain poorly understood, especially among species‐rich invertebrates. Pimoa spiders exhibit an intercontinental disjunct distribution across three major mountain regions: the Rockies, the Alps, and the Pan‐Himalaya ...
Xiaoqing Zhang, Zhe Zhao, Bingyue Zhu, Tongyao Jiang, Lili Shao, Stefano Mammola, Jiangni Li, Hao Xu, Bing Li, Shuqiang Li   +9 more
wiley   +1 more source

Hetero‐Polyatomic Phosphorous Anion‐Based High‐Entropy Electrocatalyst for Efficient Bifunctional Water Electrolysis in Anion Exchange Membrane Water Electrolyzers

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This study aims to propose and design a highly active and durable bifunctional hetero‐polyatomic phosphorous anions‐based electrocatalyst (CoFeNiMoTiPi) featuring an amorphous, porous structure synthesized via a simple hierarchical hybrid approach based on a combination of electrochemical deposition.
Yogendra Rosyara, Seunghwan Jo, Liting Zhang, Ruhao Cui, Seong Hyeok Kwon, Eunmin Kim, Jung Inn Sohn   +6 more
wiley   +1 more source

Effects of sodium–glucose co‐transporter inhibitors on individual clinical endpoints and quality of life

ESC Heart Failure, Volume 12, Issue 2, Page 1271-1282, April 2025.
Effects of SGLTi on Individual Clinical Endpoints and Quality‐of‐Life: outcome from randomized data. Abstract Aims Sodium–glucose co‐transporter inhibitors (SGLTis) have cardiovascular protective effects. We aimed to assess the effects of SGLTis on individual hard clinical endpoints and quality of life (QoL) in patients with cardiovascular risk factors.
Jia Liao, Yang Chen, Zhiyu Ling, Helmut Pürerfellner, Martin Martinek, Michael Derndorfer, Johannes Niel, Ramin Ebrahimi, Matthias Heukäufer, Sarah Janschel, Davide Di Vece, Klaus Empen, Astrid Hummel, Bishwas Chamling, Piotr Futyma, Fahim Ebrahimi, Márcio G. Kiuchi, Shaowen Liu, Yuehui Yin, Alexandra Schratter, Willem‐Jan Acou, Philipp Sommer, Boris Schmidt, Julian K. R. Chun, Christian Meyer, Marcus Dörr, Christian Templin, Shaojie Chen   +27 more
wiley   +1 more source