Results 61 to 70 of about 26,991 (196)

An interpretable radiomics–deep learning nomogram from whole‐body bone scintigraphy for MDP‐avid bone metastasis prediction in NSCLC

Journal of Applied Clinical Medical Physics, Volume 27, Issue 8, August 2026.
Abstract Background Whole‐body bone scintigraphy (WBS) remains a widely used first‐line screening tool for bone metastasis, but differentiating MDP‐avid metastatic lesions from benign bone abnormalities in non‐small cell lung cancer (NSCLC) remains challenging. Purpose To develop and externally validate a radiomics and deep learning bone signature (RDB)
Weihao Zhai, Xiaolin Li, Qian Zhou, Taohu Zhou, Yi Wang, Xiuxiu Zhou, Xin'ang Jiang, Ziwei Zhang, Qianxi Jin, Shiyuan Liu, Li Fan   +10 more
wiley   +1 more source

Nanoplatforms for Sentinel and Tumor‐Draining Lymph Node Mapping: From Visualization to Pathway‐Informed Staging

Advanced Healthcare Materials, Volume 15, Issue 30, 14 August 2026.
Lymphotropic nanoplatforms integrate multimodal imaging with therapeutic guidance to map sentinel and tumor‐draining lymph nodes, revealing functional drainage, metastatic involvement, and nodal accessibility, while providing mechanistic insight to support precision surgical and therapeutic interventions.
Xu Chen, Nina Li, Meiyan Zou, Zihao Zhou, Rongwei Xu, Weiyao Feng, Xinyuan Zhao, Li Cui   +7 more
wiley   +1 more source

Radio-labeling of T7 Peptide with 99mTc and Its Biodistribution 
in Nude Mice Bearing Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2014
Background and objective Lung cancer is a malignant tumor with high mortality rates. This study aims to develop potential candidates of integrin αvβ3 imaging agents, which can facilitate the diagnosis and treatment of lung cancer.
Yumei HAO, Xin HE, Xiaoliang ZHOU, Aimin MENG, Jianfeng LIU, Jinjian LIU, Naling SONG   +6 more
doaj   +1 more source

[Tumor affinity of 99mTc-labeled radiopharmaceuticals, 99mTc-Sn-urokinase and 99mTc-Sn-mannitol].

Radioisotopes, 1977
Biolgic distribution of 99mTc-labeled fibrinolytic agent, urokinase, and 99mTc-labeled mannitol, which was obtained as a side-product in the preparation of 99mTc(Sn)-urokinase, have been studied in Ehrlich's tumor-bearing mice to get a promising indicator for the positive delineation of malignant tumor.
K, Ito, S, Kobayashi, K, Hisada, N, Tonami, A, Ando   +4 more
openaire   +1 more source

Balancing Stealth and Targetability: cCPP‐ and PEG‐Modified Liposomes for the Targeted Delivery of Anti‐HER2 Nanobodies

Advanced Science, Volume 13, Issue 43, 3 August 2026.
This study addresses the rapid renal clearance of anti‐HER2 nanobodies by developing specialized liposomal carriers. It details the formulation of dual modified liposomes, demonstrating how PEGylation preserves structural integrity and cell‐penetrating peptides enhance cellular interaction.
Giulia Pander, Maria del Pilar Palacios Cisneros, Clara Certa, Megan Stierli, Katharina Beck, Nicolas Färber, Lisa Blank, Fiona Tanner, Eric Mühlberg, Sabrina Wohlfart, Christian Kleist, Jörg Huwyler, Gert Fricker, Walter Mier, Philipp Uhl   +14 more
wiley   +1 more source

Lesion based diagnostic performance of dual phase 99mTc-MIBI SPECT/CT imaging and ultrasonography in patients with secondary hyperparathyroidism

BMC Medical Imaging, 2017
Background We aimed to evaluate the diagnostic performance of 99mTc-MIBI SPECT/CT and ultrasonography in patients with secondary hyperparathyroidism (SHPT), and explored the factors that affect the diagnostic performance.
Panli Li, Qiufang Liu, Daoqiang Tang, Yinyan Zhu, Lian Xu, Xiaoguang Sun, Shaoli Song   +6 more
doaj   +1 more source

Bilateral Knee Osteonecrosis in an Adolescent With Leukemia on Prolonged Corticosteroids: Discordant Femoral–Tibial Findings on Bone Scan SPECT–CT

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Osteonecrosis (avascular necrosis, AVN) is a disabling complication of corticosteroid exposure and is well recognized in adolescents treated for hematologic malignancies, including acute lymphoblastic leukemia (ALL). We report a 17‐year‐old female with ALL and later acute myelogenous leukemia (AML) after hematopoietic stem cell transplantation
Fatemeh Haghighi, Fatemeh Tahghighi Sharabian, Fatemeh Jooshaei, Farzaneh Ghaffari Yousefzadeh, Marzieh Ebrahimi, Zeinab Paymani   +5 more
wiley   +1 more source

Quantitative renal [99mTc]DMSA imaging predicts urinary [99mTc]DMSA excretion in patients with chronic kidney disease

EJNMMI Research
Background 99mTc-labelled Dimercaptosuccinic acid ([99mTc]DMSA) is a radiopharmaceutical commonly used to evaluate renal perfusion, structure, and morphology. However, the renal handling of [99mTc]DMSA in humans remains unclear.
Danny Jensen, Jesper Frank Andersen, Peder Berg, Henrik Birn, Christian Flø, Jørgen Frøkiær   +5 more
doaj   +1 more source

Lymphatic Drainage of Cerebrospinal Fluid Using Lymph Node Seeker 64Cu‐Labeled Gram‐Negative Bacterial Extracellular Vesicles With Positron Emission Tomography (PET)

Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.
ABSTRACT Cerebrospinal fluid (CSF) is drained into the systemic lymphatics via paravertebral lymph nodes. Superficial and deep cervical lymph nodes collect CSF in mice, but the exact and quantified routes are unknown. Recently, we simultaneously visualized cervical, sacral and iliac lymph nodes via serial imaging on the intrathecal [64Cu]Cu‐albumin ...
Kyuwan Kim, Changjin Lee, Hayoung Shin, Ran Ji Yoo, Yoori Choi, Chanwoo Lee, Insoo Kim, Jaewook Lee, Minseok Suh, Yun‐Sang Lee, Yong Song Gho, Dong Soo Lee   +11 more
wiley   +1 more source

Usefulness of additional [99mTc]NaTcO4 SPECT/CT after standard combination of [99mTc]Tc-MIBI SPECT/CT and neck ultrasonography — improving the efficiency of parathyroid imaging in inconclusive cases

Nuclear Medicine Review
BACKGROUND: The current standard method in hyperparathyroidism imaging is the combination of [99mTc]Tc-methoxyisobutylisonitrile ([99mTc]Tc-MIBI) single photon emission computed tomography/computed tomography (SPECT/CT) and neck ultrasonography (nUS ...
Aleksandra Aulich, Anita Dyczka, Janusz Dąbrowski, Paweł Cichocki, Zbigniew Adamczewski   +4 more
doaj   +1 more source