Results 131 to 140 of about 268,148 (374)

Aβ(1–42) Fibril Structure Illuminates Self-recognition and Replication of Amyloid in Alzheimer’s

Nature Structural &Molecular Biology, 2015
Increasing evidence has suggested that formation and propagation of misfolded aggregates of 42-residue human amyloid β (Aβ(1–42)), rather than of the more abundant Aβ(1–40), provokes the Alzheimer's disease cascade.
Yiling Xiao, B. Ma, Dan McElheny, Sudhakar Parthasarathy, Fei Long, M. Hoshi, R. Nussinov, Y. Ishii   +7 more
semanticscholar   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

MOESM1 of Anthocyanins encapsulated by PLGA@PEG nanoparticles potentially improved its free radical scavenging capabilities via p38/JNK pathway against Aβ1â 42-induced oxidative stress

, 2017
Additional file 1. Additional figures.
Amin, Faiz, Shah, Shahid, Badshah, Haroon, Mehtab Khan, Kim, Myeong   +4 more
openaire   +1 more source

Mitochondrial protection by the mixed muscarinic/σ1 ligand ANAVEX2-73, a tetrahydrofuran derivative, in Aβ25–35 peptide-injected mice, a nontransgenic Alzheimer’s disease model [PDF]

Frontiers in Cellular Neuroscience, 2015
Alzheimer's disease (AD), the most prevalent dementia in the elderly, is characterized by progressive synaptic and neuronal loss. Mitochondrial dysfunctions have been consistently reported as an early event in AD and appear before Aβ deposition and memory decline.
Lahmy, Valentine, Long, Romain, Morin, Didier, Villard, Vanessa, Maurice, Tangui   +4 more
openaire   +2 more sources

Overcoming antigen masking of anti-amyloidbeta antibodies reveals breaking of B cell tolerance by virus-like particles in amyloidbeta immunized amyloid precursor protein transgenic mice

BMC Neuroscience, 2004
Background In prior work we detected reduced anti-Aβ antibody titers in Aβ-vaccinated transgenic mice expressing the human amyloid precursor protein (APP) compared to nontransgenic littermates.
Ugen Kenneth E, Gordon Marcia, Schiller John, Chackerian Bryce, Cao Chuanhai, Li Qingyou, Morgan Dave   +6 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Intravenously Injected Amyloid-β Peptide With Isomerized Asp7 and Phosphorylated Ser8 Residues Inhibits Cerebral β-Amyloidosis in AβPP/PS1 Transgenic Mice Model of Alzheimer’s Disease

Frontiers in Neuroscience, 2018
Cerebral β-amyloidosis, an accumulation in the patient’s brain of aggregated amyloid-β (Aβ) peptides abnormally saturated by divalent biometal ions, is one of the hallmarks of Alzheimer’s disease (AD).
Sergey A. Kozin, Evgeny P. Barykin, Georgy B. Telegin, Alexander S. Chernov, Alexei A. Adzhubei, Sergey P. Radko, Sergey P. Radko, Vladimir A. Mitkevich, Alexander A. Makarov   +8 more
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Additional file 3: of The characterization of AD/PART co-pathology in CJD suggests independent pathogenic mechanisms and no cross-seeding between misfolded Aβ and prion proteins

, 2019
Table S3. Influence of CJD histotype and strain on AD pathology. Relative risk ratio (RRR) was calculated by a multinomial logistic regression adjusted for age at death. For independent variables, MM(V)1 histotype and M1 strain were set as reference groups for histotype and strain analysis, respectively.
Rossi, Marcello, Kai, Hideaki, Baiardi, Simone, Bartoletti-Stella, Anna, CarlĂ, Benedetta, Zenesini, Corrado, Capellari, Sabina, Tetsuyuki Kitamoto, Parchi, Piero   +8 more
openaire   +1 more source

Bapineuzumab Alters Aβ Composition: Implications for the Amyloid Cascade Hypothesis and Anti-Amyloid Immunotherapy

PLoS ONE, 2013
The characteristic neuropathological changes associated with Alzheimer's disease (AD) and other lines of evidence support the amyloid cascade hypothesis. Viewing amyloid deposits as the prime instigator of dementia has now led to clinical trials of multiple strategies to remove or prevent their formation.
Roher, Alex E, Cribbs, David H, Kim, Ronald C, Maarouf, Chera L, Whiteside, Charisse M, Kokjohn, Tyler A, Daugs, Ian D, Head, Elizabeth, Liebsack, Carolyn, Serrano, Geidy, Belden, Christine, Sabbagh, Marwan N, Beach, Thomas G, Khoury, Joseph E   +13 more
openaire   +6 more sources