Results 121 to 130 of about 268,148 (374)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Additional file 5: of The characterization of AD/PART co-pathology in CJD suggests independent pathogenic mechanisms and no cross-seeding between misfolded Aβ and prion proteins

, 2019
Table S5. Influence of PRNP codon 129 and PrPSc type on AD pathology. Relative risk ratio (RRR) was calculated by a multinomial logistic regression adjusted for age at death. For independent variables, PRNP genotype homozygous for methionine (MM) and PrPSc type 1 were set as reference groups for PRNP codon 129 and PrPSc type analysis, respectively. For
Rossi, Marcello, Kai, Hideaki, Baiardi, Simone, Bartoletti-Stella, Anna, CarlĂ, Benedetta, Zenesini, Corrado, Capellari, Sabina, Tetsuyuki Kitamoto, Parchi, Piero   +8 more
openaire   +1 more source

Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal Aβ accumulation [PDF]

Frontiers in Aging Neuroscience, 2014
Abnormalities and impairments in axonal transport are suggested to strongly contribute to the pathological alterations underlying AD. The exact mechanisms leading to axonopathy are currently unclear, but it was recently suggested that APP expression itself triggers axonal degeneration.
Christensen, Ditte Zerlang, Huettenrauch, Melanie, Mitkovski, Miso, Pradier, Laurent, Wirths, Oliver   +4 more
openaire   +4 more sources

Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface. [PDF]

, 2019
Amyloid-β (Aβ) harbors numerous posttranslational modifications (PTMs) that may affect Alzheimer's disease (AD) pathogenesis. Here we present the 1.1 Å resolution MicroED structure of an Aβ 20-34 fibril with and without the disease-associated PTM, L ...
Boyer, David R, Cascio, Duilio, Clarke, Steven G, Eisenberg, David S, Gonen, Tamir, Richards, Logan S, Sawaya, Michael R, Warmack, Rebeccah A, Zee, Chih-Te   +8 more
core  

Clearance of cerebral Aβ in Alzheimer’s disease: reassessing the role of microglia and monocytes

Cellular and Molecular Life Sciences, 2017
Deficiency in cerebral amyloid β-protein (Aβ) clearance is implicated in the pathogenesis of the common late-onset forms of Alzheimer’s disease (AD).
L. Zuroff, David A. Daley, K. Black, M. Koronyo-Hamaoui   +3 more
semanticscholar   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Additional file 4: of The characterization of AD/PART co-pathology in CJD suggests independent pathogenic mechanisms and no cross-seeding between misfolded Aβ and prion proteins

, 2019
Table S4. Level of AD pathology in the CJD groups stratified by PRNP codon 129 genotype and PrPSc type. *The two VPSPr cases were not included. (DOCX 16 kb)
Rossi, Marcello, Kai, Hideaki, Baiardi, Simone, Bartoletti-Stella, Anna, CarlĂ, Benedetta, Zenesini, Corrado, Capellari, Sabina, Tetsuyuki Kitamoto, Parchi, Piero   +8 more
openaire   +1 more source

High-Fat-Diet-Induced Weight Gain Ameliorates Bone Loss without Exacerbating AβPP Processing and Cognition in Female APP/PS1 Mice [PDF]

Frontiers in Cellular Neuroscience, 2014
Osteoporosis is negatively correlated with body mass, whereas both osteoporosis and weight loss occur at higher incidence during the progression of Alzheimer's disease (AD) than the age-matched non-dementia individuals. Given that there is no evidence that being overweight is associated with AD-type cognitive dysfunction, we hypothesized that moderate ...
Peng, Yunhua, Liu, Jing, Tang, Ying, Liu, Jianshu, Han, Tingting, Han, Shujun, Li, Hua, Hou, Chen, Liu, Jiankang, Long, Jiangang   +9 more
openaire   +3 more sources

Copper Overload Promotes β-amyloid Induced NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis in Alzheimer’s Disease

Journal of Integrative Neuroscience
Purpose: Alzheimer’s disease (AD) is characterized by cognitive decline and abnormal protein accumulation. Copper imbalance and pyroptosis play significant roles in the pathogenesis of AD.
Min-Juan Zhu, Ling Zhang, Chang-Peng Wang   +2 more
doaj   +1 more source

Astrocytes and microglia but not neurons preferentially generate N-terminally truncated Aβ peptides

Neurobiology of Disease, 2015
The neuropathological hallmarks of Alzheimer's disease include extracellular neuritic plaques and neurofibrillary tangles. The neuritic plaques contain β-amyloid peptides (Aβ peptides) as the major proteinaceous constituent and are surrounded by ...
Timo Jan Oberstein, Philipp Spitzer, Hans-Wolfgang Klafki, Philipp Linning, Florian Neff, Hans-Joachim Knölker, Piotr Lewczuk, Jens Wiltfang, Johannes Kornhuber, Juan Manuel Maler   +9 more
doaj   +1 more source