Results 101 to 110 of about 268,148 (374)

Removal of Aβ Oligomers from the Blood: A Potential Therapeutic System for Alzheimer’s Disease

Neuropsychiatric Disease and Treatment, 2020
Yuta Saito, 1–3 Miwa Sakata, 3 Moe Kobayakawa, 3 Hiroshi Kawachi, 4 Kazunori Kawaguchi, 3 Yoshiyuki Hiki, 3 Masao Kato, 1 Mayuko Mori, 1, 3 Midori Hasegawa, 1 Norimi Ohashi, 4 Yukio Yuzawa, 1 Nobuya Kitaguchi 3 1Department of Nephrology, School of
Saito Y, Sakata M, Kobayakawa M, Kawachi H, Kawaguchi K, Hiki Y, Kato M, Mori M, Hasegawa M, Ohashi N, Yuzawa Y, Kitaguchi N   +11 more
doaj  

The Level of NMDA Receptor in the Membrane Modulates Amyloid-β Association and Perforation [PDF]

, 2016
Alzheimer’s disease is a neurodegenerative disorder that affects mostly the elderly. The main histopathological markers are the senile plaques formed by amyloid-β peptide (Aβ) aggregates that can perforate the plasma membrane of cells, increasing the ...
Aguayo, Luis G, Fernández-Pérez, Eduardo, Peoples, Robert W., Peters, Christian, Sepúlveda, Fernando J.   +4 more
core   +1 more source

Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology.

Neuron, 2019
Studies have shown an overlap of Aβ plaques, tau tangles, and α-synuclein (α-syn) pathologies in the brains of Alzheimer's disease (AD) and Parkinson's disease (PD) with dementia (PDD) patients, with increased pathological burden correlating with ...
F. Bassil, Hannah J. Brown, Shankar Pattabhiraman, Joe E. Iwasyk, Chantal M. Maghames, Emily S. Meymand, Timothy O. Cox, Dawn M. Riddle, Bin Zhang, J. Trojanowski, V. Lee   +10 more
semanticscholar   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Electrochemical Monitoring of the Interaction of Cu(II) with Amyloid-B Peptides on Boron-Doped Diamond Electrode

International Journal of Electrochemical Science, 2012
Interaction of amyloid-β peptides (Aβ), Aβ fragments, and mutated Aβ with Cu(II) was systematically investigated using cyclic voltammetry (CV) on boron-doped diamond electrode with outstanding electrochemical properties.
Yanli Zhou, Zhaohui Huo, Xu Zhu, Xiaohua Zhu, Maotian Xu, Yong Liang   +5 more
doaj   +1 more source

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism [PDF]

, 2018
Table S1. Demographic and clinical features of human subjects used in this study. Figure S1. Aβ deposition in microvessels in AD patients and APPSw/0 mice. Figure S2. Biochemical analysis of Aβ42 aggregates. Figure S3.
Herz, Joachim, Holtzman, David M, Ma, Qingyi, Owens, Nelly Chuqui, Sagare, Abhay P, Verghese, Philip B, Wang, Min, Wu, Yingxi, Zhao, Zhen, Zlokovic, Berislav V   +9 more
core   +3 more sources

Soluble Aβ oligomers and protofibrils induce NLRP3 inflammasome activation in microglia

Journal of Neurochemistry, 2019
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder causing memory loss, language problems and behavioural disturbances. AD is associated with the accumulation of fibrillar amyloid‐β (Aβ) and the formation of neurofibrillary tau ...
Asta Lučiūnaitė, R. McManus, Marija Jankunec, I. Rácz, C. Dansokho, I. Dalgėdienė, S. Schwartz, F. Brosseron, Michael T. Heneka   +8 more
semanticscholar   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Incoordination between spikes and LFPs in Aβ1−42-mediated memory deficits in rats [PDF]

Frontiers in Behavioral Neuroscience, 2014
Alzheimer's disease (AD) is a neurodegenerative disease that gradually induces cognitive deficits. Impairments of working memory have been typically observed in AD. It is well known that spikes and local field potentials (LFPs) as well as the coordination between them encode information in normal brain function.
Bai, Wenwen, Yi, Hu, Liu, Tiaotiao, Wei, Jing, Tian, Xin   +4 more
openaire   +3 more sources

Time to Amyloid Positivity and Preclinical Changes in Brain Metabolism, Atrophy, and Cognition: Evidence for Emerging Amyloid Pathology in Alzheimer's Disease

Frontiers in Neuroscience, 2017
Background: Aβ pathology is associated with longitudinal changes of brain metabolism, atrophy, and cognition, in cognitively healthy elders. However, Aβ information is usually measured cross-sectionally and dichotomized to classify subjects as Aβ ...
Philip S. Insel, Philip S. Insel, Philip S. Insel, Rik Ossenkoppele, Devon Gessert, William Jagust, William Jagust, Susan Landau, Susan Landau, Oskar Hansson, Oskar Hansson, Michael W. Weiner, Michael W. Weiner, Niklas Mattsson, Niklas Mattsson, Niklas Mattsson, for the Alzheimer's Disease Neuroimaging Initiative   +16 more
doaj   +1 more source