Results 81 to 90 of about 268,148 (374)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer’s disease

Acta Neuropathologica Communications, 2018
Alzheimer’s disease (AD) is the most common cause of dementia among older adults. Accumulation of amyloid-β (Aβ) in the brain is considered central in AD pathogenesis and its understanding crucial for developing new diagnostic and therapeutic approaches.
Maria Luisa Moro, Andrew Stephen Phillips, Katie Gaimster, Christian Paul, Amritpal Mudher, James A. R. Nicoll, Delphine Boche   +6 more
doaj   +1 more source

General amyloid inhibitors? A critical examination of the inhibition of IAPP amyloid formation by inositol stereoisomers. [PDF]

, 2014
Islet amyloid polypeptide (IAPP or amylin) forms amyloid deposits in the islets of Langerhans; a process that is believed to contribute to the progression of type 2 diabetes and to the failure of islet transplants.
Raleigh, David, Wang, Hui
core   +2 more sources

Additional file 3: of Impact of frequent cerebrospinal fluid sampling on Aβ levels: systematic approach to elucidate influencing factors

, 2016
Table S1 presenting an overview of individual participant characteristics at baseline. (PDF 97 kb)
Broeck, Bianca Van, Timmers, Maarten, Ramael, Steven, Bogert, Jennifer, Shaw, Leslie, Mercken, Marc, Slemmon, John, Nueten, Luc Van, Engelborghs, Sebastiaan, Streffer, Johannes   +9 more
openaire   +1 more source

Age-related changes of protein SUMOylation balance in the AβPP Tg2576 mouse model of Alzheimer's disease [PDF]

Frontiers in Pharmacology, 2014
Alzheimer's disease (AD) is a complex disorder that affects the central nervous system causing a severe neurodegeneration. This pathology affects an increasing number of people worldwide due to the overall aging of the human population. In recent years SUMO protein modification has emerged as a possible cellular mechanism involved in AD.
NISTICO', ROBERT GIOVANNI, Ferraina, C, Marconi, V, Blandini, F, Negri, L, Egebjerg, J, Feligioni, M.   +6 more
openaire   +5 more sources

Structure-based inhibitors of amyloid beta core suggest a common interface with tau. [PDF]

, 2019
Alzheimer's disease (AD) pathology is characterized by plaques of amyloid beta (Aβ) and neurofibrillary tangles of tau. Aβ aggregation is thought to occur at early stages of the disease, and ultimately gives way to the formation of tau tangles which ...
Bowler, Jeannette, Cascio, Duilio, Eisenberg, David S, Glabe, Charles G, Gonen, Tamir, Griner, Sarah L, Murray, Kevin A, Philipp, Stephan, Rodriguez, Jose A, Sahay, Shruti, Sawaya, Michael R, Seidler, Paul, Sosna, Justyna, Yang, Tianxiao Peter   +13 more
core   +1 more source

Naturally occurring autoantibodies against beta-amyloid: investigating their role in transgenic animal and in vitro models of Alzheimer's disease [PDF]

, 2011
Alzheimer's disease (AD) is a neurodegenerative disorder primarily affecting regions of the brain responsible for higher cognitive functions. Immunization against β-amyloid (Aβ) in animal models of AD has been shown to be effective on the molecular level
Al-Abed, Yousef, Andrei-Selmer, Luminita-Cornelia, Bacher, Michael, Balakrishnan, Karthikeyan, Balzer-Geldsetzer, Monika, Deuster, Oliver, Dodel, Richard, Du, Yansheng, Keyvani, Kathy, Neff, Frauke, Noelker, Carmen, Oertel, Wolfgang, Röskam, Stephan, Stüer, Carsten   +13 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Differential role of CSF alpha-synuclein species, tau, and Aβ42 in Parkinson's Disease [PDF]

Frontiers in Aging Neuroscience, 2014
There is a great interest in developing cerebrospinal fluid (CSF) biomarkers for diagnosis and prognosis of Parkinson's disease (PD). CSF alpha synuclein (α-syn) species, namely total and oligomeric α-syn (t-α-syn and o-α-syn), have shown to be of help for PD diagnosis.
Lucilla eParnetti, Lucia eFarotti, Paolo eEusebi, Paolo eEusebi, Davide eChiasserini, Claudia eDe Carlo, David eGiannandrea, Nicola eSalvadori, Viviana eLisetti, Nicola eTambasco, Aroldo eRossi, Nour K Majbour, Shiji eVarghese, Omar eEl-Agnaf, Omar eEl-Agnaf, Paolo eCalabresi, Paolo eCalabresi   +16 more
openaire   +4 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source