Results 91 to 100 of about 268,148 (374)

Systemic vaccination with anti‐oligomeric monoclonal antibodies improves cognitive function by reducing Aβ deposition and tau pathology in 3xTg‐AD mice [PDF]

Journal of Neurochemistry, 2013
AbstractAlzheimer's disease (AD) is a devastating disorder that is clinically characterized by a comprehensive cognitive decline. Accumulation of the amyloid‐beta (Aβ) peptide plays a pivotal role in the pathogenesis of AD. In AD, the conversion of Aβ from a physiological soluble monomeric form into insoluble fibrillar conformation is an important ...
Rasool, Suhail, Martinez-Coria, Hilda, Wu, Jessica W, LaFerla, Frank, Glabe, Charles G   +4 more
openaire   +4 more sources

Different Amyloid-β Self-Assemblies Have Distinct Effects on Intracellular Tau Aggregation. [PDF]

, 2019
Alzheimer's disease (AD) pathology is characterized by the aggregation of beta-amyloid (Aβ) and tau in the form of amyloid plaques and neurofibrillary tangles in the brain.
Bitan, Gal, Di, Jing, Jiang, Lin, Li, Binsen, Murray, Kevin A, Shin, Woo Shik, Sun, Chuanqi   +6 more
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Brain Alterations and Clinical Symptoms of Dementia in Diabetes: Aβ/Tau-Dependent and Independent Mechanisms [PDF]

Frontiers in Endocrinology, 2014
Emerging evidence suggests that diabetes affects cognitive function and increases the incidence of dementia. However, the mechanisms by which diabetes modifies cognitive function still remains unclear. Morphologically, diabetes is associated with neuronal loss in the frontal and temporal lobes including the hippocampus, and aberrant functional ...
Naoyuki eSato, Naoyuki eSato, Ryuichi eMorishita   +2 more
openaire   +3 more sources

Relationships between educational attainment, hypertension, and amyloid negative subcortical vascular dementia: The brain-battering hypothesis

Frontiers in Neuroscience, 2022
PurposeMany epidemiological studies suggest that lower education levels and vascular risk factors increase the likelihood of developing Alzheimer's disease dementia (ADD) and subcortical vascular dementia (SVaD).
Song Hwangbo, Song Hwangbo, Young Ju Kim, Young Ju Kim, Yu Hyun Park, Yu Hyun Park, Hee Jin Kim, Hee Jin Kim, Duk L. Na, Duk L. Na, Duk L. Na, Duk L. Na, Hyemin Jang, Hyemin Jang, Hyemin Jang, Sang Won Seo, Sang Won Seo, Sang Won Seo, Sang Won Seo, Sang Won Seo   +19 more
doaj   +1 more source

The interaction of amyloid A beta(1-40) with lipid bilayers and ganglioside as studied by P-31 solid-state NMR [PDF]

, 2009
Amyloid P-peptide (A beta) is a major component of plaques in Alzheimer's disease, and formation of senile plaques has been suggested to originate fro m regions of neuronal membrane rich in gangliosides. We analyzed the mode of interaction of A beta with
Asakura, T., Nakazawa, Y., Saito, H., Suzuki, Y., Williamson, M.P.   +4 more
core   +1 more source

Postmortem neocortical ³H‐PiB binding and levels of unmodified and pyroglutamate Aβ in Down syndrome and sporadic Alzheimer’s disease [PDF]

, 2022
Violetta N. Pivtoraiko, Tamara Racic, Eric E. Abrahamson, Victor L. Villemagne, Benjamin L. Handen, Ira T. Lott, Elizabeth Head, Miloš D. Ikonomović   +7 more
openalex   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Additional file 1: Table S1. of Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells

, 2016
Heparin sulfate proteoglycan (HSPG) primer pairs for quantitative polymerase chain reaction (qPCR). (DOCX 20 kb)
Reynolds, Matthew, Itender Singh, Tej Azad, Holmes, Brandon, Verghese, Phillip, Dietrich, Hans, Diamond, Marc, Guojun Bu, Han, Byung, Zipfel, Gregory   +9 more
openaire   +1 more source

Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease [PDF]

Frontiers in Aging Neuroscience, 2014
The greatest risk factor for Alzheimer's disease (AD) is age, and changes in the ageing nervous system are likely contributors to AD pathology. Amyloid beta (Aβ) accumulation, which occurs as a result of the amyloidogenic processing of amyloid precursor protein (APP), is thought to initiate the pathogenesis of AD, eventually leading to neuronal cell ...
Oyinkan eSofola-Adesakin, Oyinkan eSofola-Adesakin, Jorge Ivan eCastillo-Quan, Jorge Ivan eCastillo-Quan, Charalampos eRallis, Luke S Tain, Ivana eBjedov, Ivana eBjedov, Iain eRogers, Li eLi, Pedro eMartinez, Pedro eMartinez, Mobina eKhericha, Mobina eKhericha, Melissa eCabecinha, Jurg eBahler, Linda ePartridge, Linda ePartridge   +17 more
openaire   +6 more sources