Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation [PDF]
, 2015 Increasing evidence suggests that recurrent Herpes Simplex Virus type 1 (HSV-1) infection spreading to the CNS is a risk factor for Alzheimer's Disease (AD) but the underlying mechanisms have not been fully elucidated yet.
De Chiara, Giovanna +7 more
core +2 more sources
3,6'‐disinapoyl sucrose attenuates Aβ1‐42‐ induced neurotoxicity in Caenorhabditis elegans by enhancing antioxidation and regulating autophagy [PDF]
, 2022 Xiaoli Tang +6 more
openalex +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Short‐term modern life‐like stress exacerbates Aβ‐pathology and synapse loss in 3xTg‐
Journal of Neurochemistry, 2015 AbstractAlzheimer's disease (AD) is a progressive neurological disorder that impairs memory and other cognitive functions in the elderly. The social and financial impacts of AD are overwhelming and are escalating exponentially as a result of population aging.
Baglietto-Vargas, David +9 more
openaire +5 more sources
Intracellular distribution of amyloid beta peptide and its relationship to the lysosomal system
Translational Neurodegeneration, 2012 Background Amyloid beta peptide (Aβ) is the main component of extraneuronal senile plaques typical of Alzheimer’s disease (AD) brains. Although Aβ is produced by normal neurons, it is shown to accumulate in large amounts within neuronal lysosomes in AD ...
Zheng Lin +5 more
doaj +1 more source
Differences in Social Preferences - Are They Profitable for the Firm? [PDF]
, 2008 This paper analyzes the impact of heterogeneous (social) preferences on the weighting and combination of performance measures as well as on a firm’s profitability. We consider rivalry, egoism and altruism as extreme forms within the continuum of possible
Küpper, Hans-Ulrich, Sandner, Kai
core +2 more sources
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Wnt-related SynGAP1 is a neuroprotective factor of glutamatergic synapses against Aβ oligomers [PDF]
Frontiers in Cellular Neuroscience, 2015 Wnt-5a is a synaptogenic factor that modulates glutamatergic synapses and generates neuroprotection against Aβ oligomers. It is known that Wnt-5a plays a key role in the adult nervous system and synaptic plasticity. Emerging evidence indicates that miRNAs are actively involved in the regulation of synaptic plasticity. Recently, we showed that Wnt-5a is
Codocedo, Juan F. +2 more
openaire +6 more sources
Frontiers in Cellular Neuroscience, 2016 Background Accumulation of amyloid β (Aβ) is one of the main hallmarks of Alzheimer’s disease (AD). The enhancement of Aβ clearance may provide therapeutic means to restrict AD pathology. The cellular responses to different forms of Aβ in monocytic cells
Ekaterina Savchenko +9 more
doaj +1 more source
Mechanisms of Aβ Clearance and Degradation by Glial Cells
Frontiers in Aging Neuroscience, 2016 Glial cells have a variety of functions in the brain, ranging from immune defense against external and endogenous hazardous stimuli, regulation of synaptic formation, calcium homeostasis, and metabolic support for neurons.
Miriam Ries, M. Sastre
semanticscholar +1 more source