Results 71 to 80 of about 268,148 (374)

Identification and characterization of Aβ peptide interactors in Alzheimer’s disease by structural approaches [PDF]

Frontiers in Aging Neuroscience, 2014
Currently, there are very limited pharmaceutical interventions for Alzheimer's disease (AD) to alleviate the amyloid burden implicated in the pathophysiology of the disease. Alzheimer's disease is characterized immunohistologically by the accumulation of senile plaques in the brain with afflicted patients progressively losing short-term memory and ...
Philibert, Keith D., Marr, Robert A., Norstrom, Eric M., Glucksman, Marc J.   +3 more
openaire   +3 more sources

Additional file 2: of Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of Aβ-induced impaired axonal transport

, 2017
Anti-acetyl Prx1 (R2-31) antibody specifically detects acetylated Prx1 at K197. R2-31 antibody specificity was validated by immunoprecipitation of Flag tagged Prx1-WT or Prx1-K197R using anti-Flag M2 magnetic beads and probed by R2-31 antibody. Expression and immunoprecipitation of exogenous Prx1-WT-Flag or Prx1-K197R-Flag was confirmed by anti-Flag ...
Heesun Choi, Kim, Haeng, Jisoo Kim, Soohyun Kim, Jinhee Yang, Wonik Lee, Yeonju Park, Hyeon, Seung, Dong-Sup Lee, Ryu, Hoon, Junho Chung, Inhee Mook-Jung   +11 more
openaire   +1 more source

Electroacupuncture Reduces Aβ Production and BACE1 Expression in SAMP8 Mice [PDF]

Frontiers in Aging Neuroscience, 2015
Electroacupuncture (EA) has been reported to have beneficial effects on Alzheimer's disease (AD). BACE1 (β-site amyloid precursor protein-cleaving enzyme 1) is involved in the abnormal production of amyloid-β plaque (Aβ), a hallmark of AD pathophysiology.
Dong, Wei-Guo, Wang, Feng, Chen, Ye, Zheng, Xue-Hua, Xie, Yong-Cai, Guo, Wan-Qing, Shi, Hong   +6 more
openaire   +3 more sources

Additional file 1: of Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of Aβ-induced impaired axonal transport

, 2017
Human brain samples that were used in the study. F: Female. (PDF 200 kb)
Heesun Choi, Kim, Haeng, Jisoo Kim, Soohyun Kim, Jinhee Yang, Wonik Lee, Yeonju Park, Hyeon, Seung, Dong-Sup Lee, Ryu, Hoon, Junho Chung, Inhee Mook-Jung   +11 more
openaire   +1 more source

Impaired Aβ clearance: a potential link between atherosclerosis and Alzheimer’s disease [PDF]

Frontiers in Aging Neuroscience, 2015
Alzheimer's Disease (AD) and atherosclerosis remain two of the largest public health burdens in the world today. Although traditionally considered distinct pathological entities, mounting epidemiologic, clinical and experimental evidence suggests that cerebrovascular atherosclerosis and AD interact reciprocally to disrupt brain structure and function ...
Gupta, Ajay, Iadecola, Costantino
openaire   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Additional file 1: of Impact of frequent cerebrospinal fluid sampling on Aβ levels: systematic approach to elucidate influencing factors

, 2016
Details the inclusion and exclusion criteria of the study. (PDF 7 kb)
Broeck, Bianca Van, Timmers, Maarten, Ramael, Steven, Bogert, Jennifer, Shaw, Leslie, Mercken, Marc, Slemmon, John, Nueten, Luc Van, Engelborghs, Sebastiaan, Streffer, Johannes   +9 more
openaire   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Additional file 2 of Chemically treated plasma Aβ is a potential blood-based biomarker for screening cerebral amyloid deposition

, 2017
is a table presenting demographic data of the complete study cohort. (DOCX 58 kb)
Park, Jong-Chan, Han, Sun-Ho, Cho, Hyun, Byun, Min, Dahyun Yi, Choe, Young, Seokjo Kang, Jung, Eun, Won, Su, Kim, Eun, Kim, Yu, Lee, Dong, Inhee Mook-Jung   +12 more
openaire   +1 more source

Aging reduces glial uptake and promotes extracellular accumulation of Aβ from a lentiviral vector [PDF]

Frontiers in Aging Neuroscience, 2014
We used a lentiviral system for expressing secreted human Aβ in the brains of young and old APOE knock-in mice. This system allowed us to examine Aβ metabolism in vivo, and test the effects of both aging and APOE genotype, two of the strongest risk factors for Alzheimer's disease.
Zhao, Wenjuan, Zhang, Jiguo, Davis, Elizabeth G., Rebeck, G. William   +3 more
openaire   +3 more sources