Results 61 to 70 of about 268,148 (374)

Peripheral clearance of brain-derived Aβ in Alzheimer's disease: pathophysiology and therapeutic perspectives

Translational Neurodegeneration, 2020
Alzheimer’s disease (AD) is the most common type of dementia, and no disease-modifying treatments are available to halt or slow its progression. Amyloid-beta (Aβ) is suggested to play a pivotal role in the pathogenesis of AD, and clearance of Aβ from the
Yuan Cheng, Dingyuan Tian, Yanjiang Wang
semanticscholar   +1 more source

Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta. [PDF]

, 2013
Amyloid protein aggregates are associated with dozens of devastating diseases including Alzheimer's, Parkinson's, ALS, and diabetes type 2. While structure-based discovery of compounds has been effective in combating numerous infectious and metabolic ...
Eisenberg, David S, Hughes, Michael P, Jiang, Lin, Landau, Meytal, Leibly, David, Liu, Cong, Zhao, Minglei   +6 more
core   +1 more source

Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer's disease.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020
Alzheimer's disease (AD) is an age-related neurodegenerative disease with multiple predisposing factors and complicated pathogenesis. Aβ peptide is one of the most important pathogenic factors in the etiology of AD.
Yuanming Li, Jing Zhang, Jiale Wan, Anru Liu, Jinhao Sun   +4 more
semanticscholar   +1 more source

The triphenylmethane dye brilliant blue G is only moderately effective at inhibiting amyloid formation by human amylin or at disaggregating amylin amyloid fibrils, but interferes with amyloid assays; Implications for inhibitor design. [PDF]

, 2019
The development of inhibitors of islet amyloid formation is important as pancreatic amyloid deposition contributes to type-2 diabetes and islet transplant failure.
Akter, Rehana, Bhatia, Surita R, Raleigh, Daniel P, Zheng, Bingqian, Zhyvoloup, Alexander   +4 more
core   +3 more sources

MicroRNAs targeting Nicastrin regulate Aβ production and are affected by target site polymorphisms [PDF]

Frontiers in Molecular Neuroscience, 2014
Despite the growing number of genome-wide association studies, the involvement of polymorphisms in microRNA target sites (polymiRTS) in Alzheimer's disease (AD) remains poorly investigated. Recently, we have shown that AD-associated single-nucleotide polymorphisms (SNPs) present in the 3' untranslated region (3'UTR) of amyloid precursor protein (APP ...
Charlotte eDelay, Charlotte eDelay, Charlotte eDelay, Véronique eDorval, Véronique eDorval, Alice eFok, Benjamin eGrenier-Boley, Jean-Charles eLambert, G-Y eHsiung, Sebastien S Hebert, Sebastien S Hebert   +10 more
openaire   +3 more sources

Glypican 4 Regulates Aβ Internalization in Neural Stem Cells Partly via Low-Density Lipoprotein Receptor-Related Protein 1

Frontiers in Cellular Neuroscience, 2021
Neural stem cell (NSC) damage has been reported in patients with Alzheimer’s disease. Intracellular Aβ plays a vital role in NSC damage. Heparan sulfate proteoglycans are potent mediators of Aβ enrichment in the brain. We hypothesized the heparan sulfate
Kaige Ma, Shan Xing, Yan Luan, Chenglin Zhang, Yingfei Liu, Yulang Fei, Zhichao Zhang, Yong Liu, Xinlin Chen   +8 more
doaj   +1 more source

Prion protein interacts with bace1 and differentially regulates its activity towards wild type and swedish mutant amyloid precursor protein [PDF]

, 2011
In Alzheimer disease amyloid-β (Aβ) peptides derived from the amyloid precursor protein (APP) accumulate in the brain. Cleavage of APP by the β-secretase BACE1 is the rate-limiting step in the production of Aβ.
Andersen, Anthony J. Turner, Benjannet, Bennett, Bennett, Calella, Capell, Carolyn D. Jackson, Cole, Cole, Creemers, Debbie Brown, Fukumoto, Gimbel, Haass, Haugabook, Heledd H. Griffiths, Herbert Baybutt, Hooper, Huse, Isobel J. Whitehouse, Jean C. Manson, Katherine A.B. Kellett, Kawarabayashi, Kayed, Kayed, Li, Manson, Morrissette, Mucke, Mullan, Murrell, Nigel M. Hooper, Parkin, Pedro Piccardo, Piccardo, Schwarze-Eicker, Selkoe, Spoelgen, Sun, Thinakaran, Vardy, Vassar, Vassar, Walmsley, Walsh, Whitehouse, Yamakawa, Yan, Zhao   +49 more
core   +1 more source

β-amyloid in biological samples: not all Aβ detection methods are created equal [PDF]

Frontiers in Aging Neuroscience, 2014
Alzheimer's disease (AD) is a progressive neurodegenerative disease and is the major cause of dementia in people aged 65 years and older, affecting approximately 2% of the population of industrialized countries (Mattson, 2004). The two primary histopathological lesions found within the AD brain are intracellular accumulations of hyper-phosphorylated ...
Adlard, PA, Li, Q-X, McLean, C, Masters, CL, Bush, AI, Fodero-Tavoletti, M, Villemagne, V, Barnham, KJ   +7 more
openaire   +4 more sources

Exogenous Aβ seeds induce Aβ depositions in the blood vessels rather than the brain parenchyma, independently of Aβ strain-specific information

Acta Neuropathologica Communications, 2021
Little is known about the effects of parenchymal or vascular amyloid β peptide (Aβ) deposition in the brain. We hypothesized that Aβ strain-specific information defines whether Aβ deposits on the brain parenchyma or blood vessels.
Tsuyoshi Hamaguchi, Jee Hee Kim, Akane Hasegawa, Ritsuko Goto, Kenji Sakai, Kenjiro Ono, Yoshinori Itoh, Masahito Yamada   +7 more
doaj   +1 more source

cAMP-Inhibits Cytoplasmic Phospholipase A(2) and Protects Neurons against Amyloid-beta-Induced Synapse Damage [PDF]

, 2015
A key event in Alzheimer’s disease (AD) is the production of amyloid-β (Aβ) peptides and the loss of synapses. In cultured neurons Aβ triggered synapse damage as measured by the loss of synaptic proteins. α-synuclein (αSN), aggregates of which accumulate
Bate, C, Williams, A
core   +2 more sources