Results 41 to 50 of about 268,148 (374)

The Aβ(1–38) peptide is a negative regulator of the Aβ(1–42) peptide implicated in Alzheimer disease progression

Scientific Reports, 2021
The pool of β-Amyloid (Aβ) length variants detected in preclinical and clinical Alzheimer disease (AD) samples suggests a diversity of roles for Aβ peptides. We examined how a naturally occurring variant, e.g.
Maa O. Quartey, Jennifer N. K. Nyarko, Jason M. Maley, Jocelyn R. Barnes, Maria A. C. Bolanos, Ryan M. Heistad, Kaeli J. Knudsen, Paul R. Pennington, Josef Buttigieg, Carlos E. De Carvalho, Scot C. Leary, Matthew P. Parsons, Darrell D. Mousseau   +12 more
doaj   +1 more source

Senegenin Inhibits Aβ1-42-Induced PC12 Cells Apoptosis and Oxidative Stress via Activation of the PI3K/Akt Signaling Pathway

Neuropsychiatric Disease and Treatment, 2022
Xing Ren,1 Jiwei Zhang,2 Yunnan Zhao,3 Lingzhi Sun4 1College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250014, People’s Republic of China; 2College of Acupuncture and Massage, Shandong University of ...
Ren X, Zhang J, Zhao Y, Sun L
doaj  

LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer's Disease. [PDF]

, 2019
The low-density lipoprotein receptor-related protein-1 (LRP1) has a dual role in the metabolism of the amyloid precursor protein (APP). In cellular models, LRP1 enhances amyloid-β (Aβ) generation via APP internalization and thus its amyloidogenic ...
Gordts, Philip LSM, Lechat, Benoit, Pietrzik, Claus U, Pradier, Laurent, Reekmans, Sara M, Roebroek, Anton JM, Storck, Steffen E, Van Gool, Bart   +7 more
core   +3 more sources

Quantitative proteomic analysis of differentially expressed proteins in Aβ(17-42) treated synaptosomes

Mediterranean Journal of Chemistry, 2012
Oxidative stress has been associated in the pathogenesis of numerous diseases such as various neurodegenerative disorders, ischemia, and cancer. The brain is susceptible to oxidative stress due to its high content of peroxidizable unsaturated fatty acids, high consumption of oxygen, and elevated levels of free radicals.
Jaffer Mohammed1, Joseph T. Johnson, Rukhsana Sultana, Joshua B. Owen, Tanea T. Reed   +4 more
openaire   +1 more source

Alterations in phosphatidylethanolamine levels affect the generation of Aβ [PDF]

Aging Cell, 2011
SummarySeveral studies suggest that the generation of Aβ is highly dependent on the levels of cholesterol within membranes’ detergent‐resistant microdomains (DRM). Indeed, the β‐amyloid precursor protein (APP) cleaving machinery, namely β‐ and γ‐secretases, has been shown to be present in DRM and its activity depends on membrane cholesterol levels ...
Nesic, Iva, Guix, Francesc, Vennekens, Kristel, Michaki, Vasiliki, Van Veldhoven, Paul P., Feiguin, Fabian, De Strooper, Bart, Dotti, Carlos, Wahle, Tina   +8 more
openaire   +5 more sources

A Unique GSK-3β inhibitor B10 Has a Direct Effect on Aβ, Targets Tau and Metal Dyshomeostasis, and Promotes Neuronal Neurite Outgrowth

Cells, 2020
Due to the complicated pathogenesis of Alzheimer’s disease (AD), the development of multitargeted agents to simultaneously interfere with multiple pathological processes of AD is a potential choice.
Xiao-Long Shi, Ning Yan, Ying-Jie Cui, Zhao-Peng Liu   +3 more
doaj   +1 more source

Contribution of clinical information to the predictive performance of plasma β-amyloid levels for amyloid positron emission tomography positivity

Frontiers in Aging Neuroscience, 2023
BackgroundEarly detection of β-amyloid (Aβ) accumulation, a major biomarker for Alzheimer’s disease (AD), has become important. As fluid biomarkers, the accuracy of cerebrospinal fluid (CSF) Aβ for predicting Aβ deposition on positron emission tomography
Min Young Chun, Min Young Chun, Min Young Chun, Hyemin Jang, Hyemin Jang, Hyemin Jang, Hee Jin Kim, Hee Jin Kim, Hee Jin Kim, Hee Jin Kim, Jun Pyo Kim, Jun Pyo Kim, John Gallacher, José Antonio Allué, Leticia Sarasa, Sergio Castillo, María Pascual-Lucas, Duk L. Na, Duk L. Na, Sang Won Seo, Sang Won Seo, Sang Won Seo, Sang Won Seo, Sang Won Seo, on behalf of DPUK   +24 more
doaj   +1 more source

Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue

Nature Communications, 2019
The formation of Aβ amyloid fibrils is a neuropathological hallmark of Alzheimer’s disease and cerebral amyloid angiopathy. However, the structure of Aβ amyloid fibrils from brain tissue is poorly understood. Here we report the purification of Aβ amyloid
M. Kollmer, William L. Close, Leonie Funk, Jay Rasmussen, Aref Bsoul, A. Schierhorn, Matthias Schmidt, C. Sigurdson, M. Jucker, M. Fändrich   +9 more
semanticscholar   +1 more source

Reciprocal modulation of Aβ42 aggregation by copper and homocysteine [PDF]

Frontiers in Aging Neuroscience, 2014
Hyperhomocysteinemia is a risk factor for Alzheimer's disease (AD). Both homocysteine (Hcy) and amyloid β (Aβ), which accumulates in the brain of AD patients, bind copper. Aim of this study was to test the hypothesis that the association of Hcy and AD results from a molecular interaction between Hcy and Aβ that is mediated by copper.
Keskitalo, Salla, Farkas, Melinda, Hanenberg, Michael, Szodorai, Anita, Kulic, Luka, Semmler, Alexander, Weller, Michael, Nitsch, Roger M, Linnebank, Michael   +8 more
openaire   +3 more sources

Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids. [PDF]

, 2016
The beta amyloid (Aβ) and other aggregating proteins in the brain increase with age and are frequently found within neurons. The mechanistic relationship between intracellular amyloid, aging and neurodegeneration is not, however, well understood.
Currais, Antonio, Daugherty, Daniel, M Armando, Aaron, Maher, Pam, Quehenberger, Oswald, Schubert, David   +5 more
core   +2 more sources