Results 21 to 30 of about 268,148 (374)
Journal of Integrative Neuroscience, 2023 Transthyretin (TTR) is secreted by hepatocytes, retinal pigment epithelial cells, pancreatic α and β cells, choroid plexus epithelium, and neurons under stress.
Joel N. Buxbaum
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Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer's disease.
Neuron, 2022 The pathology of Alzheimer's disease (AD) is featured with extracellular amyloid-β (Aβ) plaques, whose impact on the mechanical properties of the surrounding brain tissues is unclear. Microglia sense and integrate biochemical cues of the microenvironment.
Jin Hu +20 more
semanticscholar +1 more source
Translational Neuroscience, 2023 Sleep plays an important role in the learning process and memory consolidation, and sleep deprivation (SD) leads to inadequate memory consolidation and plays an important role in brain development and plasticity.
Yuan Ren +4 more
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Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition
eLife, 2021 Previous studies have identified a crucial role of the gut microbiome in modifying Alzheimer’s disease (AD) progression. However, the mechanisms of microbiome–brain interaction in AD were so far unknown.
A. Colombo +21 more
semanticscholar +1 more source
STX17 improves Aβ31-35 induced death of hippocampal neurons in mice
陆军军医大学学报, 2022 Objective To explore the role of STX17 protein in Aβ-induced death of mouse hippocampal neuronal cells. Methods Based on Weighted correlation network analysis (WGCNA), the modules significantly related to Alzheimer's disease (AD) were selected, and key ...
WANG Ning +4 more
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Role of Aβ in Alzheimer’s-related synaptic dysfunction
Frontiers in Cell and Developmental Biology, 2022 Synaptic dysfunction is closely related to Alzheimer’s disease (AD) which is also recognized as synaptic disorder. β-amyloid (Aβ) is one of the main pathogenic factors in AD, which disrupts synaptic plasticity and mediates the synaptic toxicity through ...
Huiqin Zhang +8 more
semanticscholar +1 more source
Neuroprotective Studies on Polygonum hydropiper L. Essential Oils Using Transgenic Animal Models
Frontiers in Pharmacology, 2021 Polygonum hydropiper L. and related species are reported to possess neuroprotective potentials. In an attempt to validate its anti-Alzheimer’s potentials, leaf oils (Ph.
Xin Tong +9 more
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Effects of running on medial prefrontal cortex and microglia in APP/PS1 mice
Di-san junyi daxue xuebao, 2022 Objective To investigate the effects of running on the volume change of medial prefrontal cortex (mPFC), as well as amyloid beta protein (Aβ) and microglia in mPFC in mouse model of Alzheimer′s disease (AD).
GUO Yijing +4 more
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Microglia contribute to the propagation of Aβ into unaffected brain tissue
Nature Neuroscience, 2021 Microglia appear activated in the vicinity of amyloid beta (Aβ) plaques, but whether microglia contribute to Aβ propagation into unaffected brain regions remains unknown.
P. d’Errico +15 more
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Acta Neuropathologica, 2020 Tau and amyloid beta (Aβ) are the prime suspects for driving pathology in Alzheimer’s disease (AD) and, as such, have become the focus of therapeutic development.
Sarah A. Kent +2 more
semanticscholar +1 more source