Results 1 to 10 of about 268,148 (374)

Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease

Neurology, 2019
Objective To examine the cross-sectional associations between regional tau, β-amyloid (Aβ), and cortical thickness and neuropsychological function across the preclinical and clinical spectrum of Alzheimer disease (AD).
R. Ossenkoppele, Ruben Smith, T. Ohlsson, O. Strandberg, N. Mattsson, P. Insel, S. Palmqvist, O. Hansson   +7 more
semanticscholar   +1 more source

Role of Calcium Homeostasis in Alzheimer’s Disease

Neuropsychiatric Disease and Treatment, 2022
Mengqian Ge,1 Jinghui zhang,2 Simiao Chen,2 Yanfen Huang,2 Weiyan Chen,3 Lan He,1 Yuyan Zhang2 1The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 2School of Life Sciences, Zhejiang Chinese ...
Ge M, Zhang J, Chen S, Huang Y, Chen W, He L, Zhang Y   +6 more
doaj  

The effects of peripheral and central high insulin on brain insulin signaling and amyloid-β in young and old APP/PS1 mice [PDF]

, 2016
Hyperinsulinemia is a risk factor for late-onset Alzheimer's disease (AD). In vitro experiments describe potential connections between insulin, insulin signaling, and amyloid-β (Aβ), but in vivo experiments are needed to validate these relationships ...
Caesar, Emily E, Holtzman, David M, Jiang, Hong, Keyser, Jennifer, Koscal, Lauren J, Macauley, Shannon L, Moritz, Will, Robinson, Grace O, Roh, Joseph, Stanley, Molly   +9 more
core   +2 more sources

CSF Aβ42 and Aβ42/Aβ40 Ratio in Alzheimer’s Disease and Frontotemporal Dementias

Diagnostics, 2023
Background: Alzheimer’s disease dementia (ADD) may manifest with atypical phenotypes, resembling behavioral variant frontotemporal dementia (bvFTD) and corticobasal syndrome (CBS), phenotypes which typically have an underlying frontotemporal lobar ...
Vasilios C. Constantinides, George P. Paraskevas, Fotini Boufidou, Mara Bourbouli, Efstratios-Stylianos Pyrgelis, Leonidas Stefanis, Elisabeth Kapaki   +6 more
doaj   +1 more source

Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity. [PDF]

, 2015
Diverse lines of evidence suggest that amyloid-β (Aβ) peptides causally contribute to the pathogenesis of Alzheimer disease (AD), the most frequent neurodegenerative disorder.
Johnson, Erik, Kim, Daniel, Knox, Joseph A, Miyamoto, Takashi, Mucke, Lennart   +4 more
core   +1 more source

Tau and Aβ imaging, CSF measures, and cognition in Alzheimer's disease

Science Translational Medicine, 2016
PET imaging of pathological tau correlates more closely with Alzheimer’s disease–related cognitive impairment than does imaging of β-amyloid. A window into Alzheimer’s disease Alzheimer’s disease is pathologically defined by the accumulation of β-amyloid
M. Brier, B. Gordon, Karl Friedrichsen, J. McCarthy, Ari Stern, Jon J. Christensen, Christopher J. Owen, Patricia Aldea, Yi Su, Jason J Hassenstab, N. Cairns, D. Holtzman, A. Fagan, J. Morris, T. Benzinger, B. Ances   +15 more
semanticscholar   +1 more source

Fasting, a Potential Intervention in Alzheimer's Disease

Journal of Integrative Neuroscience
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the onset of symptoms, typically occurring later in life, and significant deficits in cognitive functions including learning, memory, speech, and behavior.
Zhengzhong Zeng, Hu Zhang, Xianping Wang, Jiawen Shen, Danyang Chen   +4 more
doaj   +1 more source

The short-term improvements of enriched environment in behaviors and pathological changes of APP/PS1 mice via regulating cytokines

Human Vaccines & Immunotherapeutics, 2018
Objective: To study the effect of enriched environment (EE) on cognitive function and pathological changes in Alzheimer's disease (AD) mice. Method: 6-month-old of the male mice were divided into 3 groups (n = 8), the wild type C57BL/6 mice in the ...
Yuwei Zhang, Ge Wang, Lin Wang, Jian Zhao, Rui Huang, Qianying Xiong   +5 more
doaj   +1 more source

Dihydropyrimidine-thiones and clioquinol synergize to target beta-amyloid cellular pathologies through a metal-dependent mechanism [PDF]

, 2017
The lack of therapies for neurodegenerative diseases arises from our incomplete understanding of their underlying cellular toxicities and the limited number of predictive model systems.
Barrasa, M. Inmaculada, Brown, Lauren E., Caldwell, Guy A., Caldwell, Kim A., Jui, Nathan T., Lindquist, Susan, Schaus, Scott E., Tardiff, Daniel F., Trilles, Richard, Yan, Xiaohui   +9 more
core   +1 more source

Liraglutide Attenuates Aβ42 Generation in APPswe/SH-SY5Y Cells Through the Regulation of Autophagy

Neuropsychiatric Disease and Treatment, 2020
Jingjing Kong,1,* Liping Wan,2,* Yanfu Wang,1 Hua Zhang,1 Wei Zhang1 1Department of Geriatrics, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, People’s Republic of China; 2Department of Clinical Laboratory ...
Kong J, Wan L, Wang Y, Zhang H, Zhang W
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