Results 11 to 20 of about 268,148 (374)

Astrocytic LRP1 mediates brain Aβ clearance and impacts amyloid deposition [PDF]

Journal of Neuroscience, 2017
Accumulation and deposition of amyloid-β (Aβ) in the brain represent an early and perhaps necessary step in the pathogenesis of Alzheimer's disease (AD).
Bu, Guojun, Cirrito, John R, Holtzman, David M, Hu, Jin, Kanekiyo, Takahisa, Liu, Chia-Chen, Na, Wang, Wang, Jian, Zhao, Na   +8 more
core   +3 more sources

Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes. [PDF]

Journal of Experimental Medicine, 2019
We demonstrated that an antibiotic cocktail (ABX)-perturbed gut microbiome is associated with reduced amyloid-β (Aβ) plaque pathology and astrogliosis in the male amyloid precursor protein (APP)SWE /presenilin 1 (PS1)ΔE9 transgenic model of Aβ ...
Baufeld, Caroline, Butovsky, Oleg, Dodiya, Hemraj B, Gilbert, Jack A, Gottel, Neil, Kuntz, Thomas, Leibowitz, Jeffrey, Shaik, Shabana M, Sisodia, Sangram S, Zhang, Xiaoqiong, Zhang, Xulun   +10 more
core   +3 more sources

Association of Aβ with ceramide-enriched astrosomes mediates Aβ neurotoxicity [PDF]

Acta Neuropathologica Communications, 2020
Amyloid-β (Aβ) associates with extracellular vesicles termed exosomes. It is not clear whether and how exosomes modulate Aβ neurotoxicity in Alzheimer’s disease (AD). We show here that brain tissue and serum from the transgenic mouse model of familial AD
Ahmed Elsherbini, Alexander S. Kirov, Michael B. Dinkins, Guanghu Wang, Haiyan Qin, Zhihui Zhu, Priyanka Tripathi, Simone M. Crivelli, Erhard Bieberich   +8 more
doaj   +2 more sources

Aβ plaques

Free Neuropathology, 2020
Aβ plaques are one of the two lesions in the brain that define the neuropathological diagnosis of Alzheimer’s disease. Plaques are highly diverse structures; many of them include massed, fibrillar polymers of the Aβ protein referred to as Aβ-amyloid, but
Lary C Walker
doaj   +2 more sources

Endocytic uptake of monomeric amyloid-β peptides is clathrin- and dynamin-independent and results in selective accumulation of Aβ(1–42) compared to Aβ(1–40)

Scientific Reports, 2017
Intraneuronal accumulation of amyloid-β (Aβ) peptides represent an early pathological feature in Alzheimer’s disease. We have therefore utilized flow cytometry and confocal microscopy in combination with endocytosis inhibition to explore the ...
Emelie Wesén, Gavin D. M. Jeffries, Maria Matson Dzebo, Elin K. Esbjörner   +3 more
doaj   +2 more sources

Platelet glycogen synthase kinase 3β regulates plasma β amyloid and phosphorylated tau levels in chronic kidney disease patients with cognitive dysfunction; therapeutic role of erythropoietin [PDF]

Journal of Nephropathology, 2023
Introduction: Patients with chronic kidney disease (CKD) have increasingly been diagnosed with cognitive impairment. Glycogen synthase kinase 3β (GSK3β) is directly causing both phosphorylated tau (pTau) and amyloid β (Aβ) accumulation in Alzheimer’s ...
Vinothkumar Ganesan, Krishnakumar Sethuraman, Sureshkumar Sureshkumar, Venkataraman Prabhu   +3 more
doaj   +1 more source

Geniposide protection against Aβ1-42 toxicity correlates with mTOR inhibition and enhancement of autophagy [PDF]

Journal of Integrative Neuroscience, 2021
Overactivation of the PI3-K/Akt/mTOR signaling pathway and inhibition of autophagy in the brain are involved in Alzheimer’s disease. The present paper’s goal was to explore the potential mechanisms of geniposide to protect against Alzheimer’s disease.
Dong-Xing Liu, Di Zhang, Wei-Min Hu, Yan-Fang Chang, Xiao-Hui Wang, Lin Li   +5 more
doaj   +1 more source

Interaction between Aβ and Tau in the Pathogenesis of Alzheimer's Disease

International Journal on Biological Sciences, 2021
Extracellular neuritic plaques composed of amyloid‑β (Aβ) protein and intracellular neurofibrillary tangles containing phosphorylated tau protein are the two hallmark proteins of Alzheimer's disease (AD), and the separate neurotoxicity of these proteins ...
Huiqin Zhang, Wei Wei, Ming Zhao, Lina Ma, Xuefan Jiang, Hui Pei, Yu Cao, Hao Li   +7 more
semanticscholar   +1 more source

Assessment of the Interaction of Aggregatin Protein with Amyloid-Beta (Aβ) at the Molecular Level via In Silico Analysis.

Acta chimica Slovenica, 2021
Alzheimer's disease is a major neurodegenerative illness whose prevalence is increasing worldwide but the molecular mechanism remains unclear. There is some scientific evidence that the molecular complexity of Alzheimer's pathophysiology is associated with the formation of extracellular amyloid-beta plaques in the brain.
Nail, BeĹźli, Guven, Yenmis
openaire   +2 more sources

Thioflavin T as an amyloid dye: fibril quantification, optimal concentration and effect on aggregation [PDF]

Royal Society Open Science, 2017
Formation of amyloid fibrils underlies a wide range of human disorders, including Alzheimer's and prion diseases. The amyloid fibrils can be readily detected thanks to thioflavin T (ThT), a small molecule that gives strong fluorescence upon binding to ...
Christine Xue, Tiffany Yuwen Lin, Dennis Chang, Zhefeng Guo   +3 more
doaj   +1 more source