Results 221 to 230 of about 72,712 (256)
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The biological functions of A-kinase anchor proteins.
Journal of molecular biology, 2001cAMP-dependent protein kinase is targeted to discrete subcellular locations by a family of specific anchor proteins (A-kinase anchor proteins, AKAPs). Localization recruits protein kinase A (PKA) holoenzyme close to its substrate/effector proteins, directing and amplifying the biological effects of cAMP signaling.AKAPs include two conserved structural ...
FELICIELLO, ANTONIO +2 more
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Mechanisms of Protein Kinase A Anchoring
2010The second messenger cyclic adenosine monophosphate (cAMP), which is produced by adenylyl cyclases following stimulation of G-protein-coupled receptors, exerts its effect mainly through the cAMP-dependent serine/threonine protein kinase A (PKA). Due to the ubiquitous nature of the cAMP/PKA system, PKA signaling pathways underlie strict spatial and ...
Philipp, Skroblin +4 more
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Kinase-anchoring proteins in ciliary signal transduction
Biochemical Journal, 2021Historically, the diffusion of chemical signals through the cell was thought to occur within a cytoplasmic soup bounded by the plasma membrane. This theory was predicated on the notion that all regulatory enzymes are soluble and moved with a Brownian motion. Although enzyme compartmentalization was initially rebuffed by biochemists as a ‘last refuge of
Janani Gopalan +2 more
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The role of A-kinase anchoring proteins in cancer development
Cellular Signalling, 2017Cancer development is a multifactorial process resulting from the aberrant activation of multiple signaling pathways. It has become increasingly clear that the coordination of the signaling events leading to cancer formation and progression is under the control of macromolecular transduction complexes organized by scaffolding proteins.
Reggi E, Diviani D
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British Journal of Pharmacology, 2014
The universal second messenger cAMP is generated upon stimulation of G(s) protein-coupled receptors, such as the (2)-adreneoceptor, and leads to the activation of PKA, the major cAMP effector protein. PKA oscillates between an on and off state and thereby regulates a plethora of distinct biological responses. The broad activation pattern of PKA and its
Poppinga, W. J. +3 more
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The universal second messenger cAMP is generated upon stimulation of G(s) protein-coupled receptors, such as the (2)-adreneoceptor, and leads to the activation of PKA, the major cAMP effector protein. PKA oscillates between an on and off state and thereby regulates a plethora of distinct biological responses. The broad activation pattern of PKA and its
Poppinga, W. J. +3 more
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A-kinase anchor proteins in endocrine systems and reproduction
Trends in Endocrinology & Metabolism, 2001Over the past few years, significant progress has been made in characterizing the expression and localization of proteins that act as scaffolds for cAMP-dependent protein kinase (PK-A). These A-kinase anchor proteins (AKAPs) tether PK-A to intracellular organelles and structures, sequestering the kinase near its physiological substrates.
S B, Moss, G L, Gerton
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A-Kinase Anchoring Proteins as the Basis for cAMP Signaling
2008Common challenges to any cell are the processing of the extracellular stimuli it receives into intracellular signaling cascades that initiate a multitude of diverse biological functions. However, many of these stimuli act via a common signaling pathway, suggesting the cell must somehow discriminate between different stimuli and respond accordingly ...
K L, Dodge-Kafka +2 more
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Functional Anchoring of the cAMP-Dependent Protein Kinase
Trends in Cardiovascular Medicine, 1998The precision of cAMP-responsive events is controlled in part through compartmentalization of the signal transduction machinery. Recent evidence suggests that the cAMP-dependent protein kinase (PKA) is localized to specific subcellular compartments through association with A Kinase Anchoring Proteins (AKAPs).
B J, Murphy, J D, Scott
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A-kinase-anchoring proteins and cytoskeletal signalling events
Biochemical Society Transactions, 2003Targeting of protein kinases and phosphatases to the cytoskeleton enhances the regulation of many signalling events. Cytoskeletal signalling complexes facilitate this process by optimizing the relay of messages from membrane receptors to specific sites on the actin cytoskeleton.
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Modulation of cardiac function by A-kinase anchoring proteins
Current Opinion in Pharmacology, 2008The cAMP-dependent kinase (PKA) is a broad specificity kinase that controls several fundamental processes in the heart including the strength and the frequency of contraction, the duration of the cardiac action potential as well as the activation of signaling pathways associated with the onset of cardiac hypertrophy and heart failure.
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