Results 81 to 90 of about 1,280,003 (288)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
College Access and Success in Philadelphia: Part II: College Enrollment Activity [PDF]
, 2010 Presents a scan of Philadelphia public high school graduates' characteristics and their college enrollment, retention, and completion rates. Outlines implications and recommendations for local institutions and supports for college access and ...
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
A note on generalized Genome Scan Meta-Analysis statistics
BMC Bioinformatics, 2005 Background Wise et al. introduced a rank-based statistical technique for meta-analysis of genome scans, the Genome Scan Meta-Analysis (GSMA) method. Levinson et al.
Feng Anne C, Koziol James A
doaj +1 more source
Volumetric microvascular imaging of human retina using optical coherence tomography with a novel motion contrast technique [PDF]
, 2009 Phase variance-based motion contrast imaging is demonstrated using a spectral domain optical coherence tomography system for the in vivo human retina. This contrast technique spatially identifies locations of motion within the retina primarily associated
Fingler, Jeff +4 more
core +2 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Floating labyrinth: A unique finding on CT scan
Radiology Case Reports, 2020 We report a case of a 67-year-old female patient that presented to the emergency department with complete right facial paralysis, progressive hearing loss and chronic otorrhea.
Filipe Correia, M.D. +2 more
doaj +1 more source
Charge breaking bounds in the Zee model
, 2005 We study the possibility that charge breaking minima occur in the Zee model. We reach very different conclusions from those attained in simpler, two Higgs doublet models, and the reason for this is traced back to the existence of cubic terms in the ...
A. Barroso +3 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Scan speed affects quantitative optical coherence tomography angiography vascular metrics
Scientific ReportsOptical coherence tomography angiography (OCTA) offers the possibility of obtaining objective quantification of retinal vasculature, with increasing utility as biomarkers for both systemic and ocular diseases.
Lourdes Vidal-Oliver +4 more
doaj +1 more source