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Site‐selective versus promiscuous A‐to‐I editing
WIREs RNA, 2011AbstractRNA editing by adenosine deamination is acting on polymerase II derived transcripts in all metazoans. Adenosine‐to‐inosine (A‐to‐I) editing is mediated by the adenosine deaminase that acts on RNA (ADAR) enzymes. Two types of adenosine to inosine (A‐to‐I) RNA editing have been defined: site selective and hyper‐editing.
Helene, Wahlstedt, Marie, Ohman
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A-to-I RNA Editing is Induced Upon Hypoxia
Shock, 2011Regulating gene expression is part of a cell's response to hypoxia. A-to-I RNA editing is an epigenetic phenomenon that can contribute to RNA and protein levels and to isoform diversity. In this study, we identified alterations in the levels of RNA editing following hypoxic stress in three genes: MED13, STAT3, and F11R.
Yael, Nevo-Caspi +3 more
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Detection of A-to-I Hyper-edited RNA Sequences
2020Following A-to-I editing of double-stranded RNA (dsRNA) molecules, sequencing reactions interpret the edited inosine (I) as guanosine (G). For this reason, current methods to detect A-to-I editing sites work to align RNA sequences to their reference DNA sequence in order to reveal A-to-G mismatches.
Roni, Cohen-Fultheim, Erez Y, Levanon
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Genome-Wide Analysis of A-to-I RNA Editing
2016Adenosine (A)-to-inosine (I) RNA editing is a fundamental posttranscriptional modification that ensures the deamination of A-to-I in double-stranded (ds) RNA molecules. Intriguingly, the A-to-I RNA editing system is particularly active in the nervous system of higher eukaryotes, altering a plethora of noncoding and coding sequences.
Yiannis A, Savva +2 more
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Editing the message from A to I
Nature Biotechnology, 2004Numerous adenosine-to-inosine editing sites found in mRNA sequences raise new questions about the biological significance of RNA editing.
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A-to-I RNA Editing in Human Cells
2021A thesis presented to the faculty of The Rockefeller University in partial fulfillment of the requirements for the degree of Doctor of ...
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RNA A-to-I editing, environmental exposure, and human diseases
Critical Reviews in Toxicology, 2021Epigenetic modifications have gained attention since they can be potentially changed with environmental stimuli and can be associated with adverse health outcomes. Epitranscriptome field has begun to attract attention with several aspects since RNA modifications have been linked with critical biological processes and implicated in diseases. Several RNA
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