Results 191 to 200 of about 8,093,612 (203)
Some of the next articles are maybe not open access.
Aptazyme-directed A-to-I RNA editing
As a promising therapeutic approach, the RNA editing process can correct pathogenic mutations and is reversible and tunable, without permanently altering the genome. RNA editing mediated by human ADAR proteins offers unique advantages, including high specificity and low immunogenicity.Xilei, Ai, Zhuo, Tang
openaire +2 more sources
A-to-I RNA editing — immune protector and transcriptome diversifier
Nature Reviews Genetics, 2018Modifications of RNA affect its function and stability. RNA editing is unique among these modifications because it not only alters the cellular fate of RNA molecules but also alters their sequence relative to the genome. The most common type of RNA editing is A-to-I editing by double-stranded RNA-specific adenosine deaminase (ADAR) enzymes.
Eli Eisenberg, Erez Y. Levanon
openaire +3 more sources
A-to-I editing of protein coding and noncoding RNAs
Critical Reviews in Biochemistry and Molecular Biology, 2012Adenosine deaminase acting on RNA (ADAR) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) substrates. Inosine pairs preferentially with cytidine, as opposed to uridine; therefore, ADAR editing alters the sequence and base pairing properties of both protein-coding and non-coding RNA.
Arka, Mallela, Kazuko, Nishikura
openaire +2 more sources
A-to-I editing of microRNAs: Regulating the regulators?
Seminars in Cell & Developmental Biology, 2012An important epigenetic mechanism in mammals is adenosine deamination, which generates transcriptome variety through the conversion of single adenosines into inosines in RNA molecules. Inosine is interpreted as guanosine by the translational machinery, and when A-to-I RNA editing occurs in the coding region of pre-mRNA molecules this substitution can ...
openaire +2 more sources
A-to-I RNA editing: The “ADAR” side of human cancer
Seminars in Cell & Developmental Biology, 2012Carcinogenesis is a complex, multi-stage process depending on both endogenous and exogenous factors. In the past years, DNA mutations provided important clues to the comprehension of the molecular pathways involved in numerous cancers. Recently, post-transcriptional modification events, such as RNA editing, are emerging as new players in several human ...
Galeano, Federica +3 more
openaire +2 more sources
A-to-I and C-to-U editing within transfer RNAs
Biochemistry (Moscow), 2011A significant number of post-transcriptional changes occur during the generation of mature transfer RNAs (tRNAs). These changes within precursor-tRNA molecules include the processing of 5' and 3' termini, the introduction of modifications, and also RNA editing. In this review, we will detail the reported cases of A-to-I and C-to-U tRNA editing.
Su, A., Randau, L.
openaire +3 more sources
Nanopore sequencing to detect A-to-I editing sites
Adenosine-to-inosine (A-to-I) RNA editing, mediated by the ADAR family of enzymes, is pervasive in metazoans and functions as an important mechanism to diversify the proteome and control gene expression. Over the years, there have been multiple efforts to comprehensively map the editing landscape in different organisms and in different disease states ...Jia Wei Joel, Heng, Meng How, Tan
openaire +2 more sources
Bioinformatic Approaches for Identification of A-to-I Editing Sites
2011The first discoveries of mammalian A-to-I RNA editing have been serendipitous. In conjunction with the fast advancement in sequencing technology, systematic methods for prediction and detection of editing sites have been developed, leading to the discovery of thousands of A-to-I editing sites.
openaire +2 more sources
A-to-I editing prevents self-RNA sensing
Nature Reviews Molecular Cell Biology, 2022openaire +2 more sources