Results 1 to 10 of about 135,681,880 (302)
The A to I editing landscape in melanoma and its relation to clinical outcome [PDF]
RNA Biology, 2022 RNA editing refers to non-transient RNA modifications that occur after transcription and prior to translation by the ribosomes. RNA editing is more widespread in cancer cells than in non-transformed cells and is associated with tumorigenesis of various ...
Austeja Amweg +11 more
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Reovirus infection induces transcriptome-wide unique A-to-I editing changes in the murine fibroblasts. [PDF]
Virus ResearchThe conversion of Adenosine (A) to Inosine (I), by Adenosine Deaminases Acting on RNA or ADARs, is an essential post-transcriptional modification that contributes to proteome diversity and regulation in metazoans including humans.
Ayesha Tariq, Helen Piontkivska
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Developmental stage-specific A-to-I editing pattern in the postnatal pineal gland of pigs (Sus scrofa) [PDF]
Journal of Animal Science and Biotechnology, 2020 Background RNA editing is a widespread post-transcriptional modification mechanism in mammalian genomes. Although many editing sites have been identified in domestic pigs (Sus scrofa), little is known about the characteristics and dynamic regulation of ...
Rong Zhou +8 more
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Biological roles of A-to-I editing: implications in innate immunity, cell death, and cancer immunotherapy [PDF]
Journal of Experimental & Clinical Cancer Research, 2023 Adenosine-to-inosine (A-to-I) editing, a key RNA modification widely found in eukaryotes, is catalyzed by adenosine deaminases acting on RNA (ADARs). Such RNA editing destabilizes endogenous dsRNAs, which are subsequently recognized by the sensors of ...
Jing Yuan +5 more
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Effect of SNORD113-3/ADAR2 on glycolipid metabolism in glioblastoma via A-to-I editing of PHKA2 [PDF]
Cellular & Molecular Biology LettersBackground Glioblastoma multiforme (GBM) is a highly aggressive brain tumor, characterized by its poor prognosis. Glycolipid metabolism is strongly associated with GBM development and malignant behavior.
Zheng Cui +9 more
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Molecular Cancer, 2021 Background Adenosine deaminases acting on RNA (ADARs) modify many cellular RNAs by catalyzing the conversion of adenosine to inosine (A-to-I), and their deregulation is associated with several cancers.
Julia Ramírez-Moya +5 more
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The Many Roles of A-to-I RNA Editing in Animals: Functional or Adaptive?
Frontiers in Bioscience-Landmark, 2023 Metazoan adenosine-to-inosine (A-to-I) RNA editing is a highly conserved mechanism that diversifies the transcriptome by post-transcriptionally converting adenosine to inosine.
Dongwu Zhan +4 more
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L-GIREMI uncovers RNA editing sites in long-read RNA-seq
Genome Biology, 2023 Although long-read RNA-seq is increasingly applied to characterize full-length transcripts it can also enable detection of nucleotide variants, such as genetic mutations or RNA editing sites, which is significantly under-explored.
Zhiheng Liu +7 more
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Substitutional A‐to‐I RNA editing [PDF]
WIREs RNA, 2010 AbstractAdenosine‐to‐inosine (A‐to‐I) editing catalyzed by adenosine deaminases acting on RNA (ADARs) entails the chemical conversion of adenosine residues to inosine residues within double‐stranded RNA (dsRNA) substrates. Inosine base pairs as guanosine and A‐to‐I editing can therefore alter the structure and base pairing properties of the RNA ...
Bjorn-Erik, Wulff, Kazuko, Nishikura
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RNA Editing: An I for editing [PDF]
Current Biology, 1995 In vitro editing in mammalian nuclear extracts reveals adenosine-to-inosine conversions in glutamate receptor messenger RNAs.
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