Results 1 to 10 of about 2,808,906 (291)

Editing inducer elements increases A-to-I editing efficiency in the mammalian transcriptome [PDF]

Genome Biology, 2017
Background Adenosine to inosine (A-to-I) RNA editing has been shown to be an essential event that plays a significant role in neuronal function, as well as innate immunity, in mammals. It requires a structure that is largely double-stranded for catalysis
Chammiran Daniel, Albin Widmark, Ditte Rigardt, Marie Öhman   +3 more
doaj   +5 more sources

Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system [PDF]

Frontiers in Neuroscience, 2013
The fine control of molecules mediating communication in the nervous system is key to adjusting neuronal responsiveness during development and in maintaining the stability of established networks in the face of altered sensory input.
Andrew Charles Penn, Andrew Charles Penn, Ales eBalik, Ingo H Greger   +3 more
doaj   +3 more sources

The A to I editing landscape in melanoma and its relation to clinical outcome [PDF]

RNA Biology, 2022
RNA editing refers to non-transient RNA modifications that occur after transcription and prior to translation by the ribosomes. RNA editing is more widespread in cancer cells than in non-transformed cells and is associated with tumorigenesis of various ...
Austeja Amweg, Marina Tusup, Phil Cheng, Ernesto Picardi, Reinhard Dummer, Mitchell P Levesque, Lars E French, Emmanuella Guenova, Severin Läuchli, Thomas Kundig, Mark Mellett, Steve Pascolo   +11 more
doaj   +2 more sources

Reovirus infection induces transcriptome-wide unique A-to-I editing changes in the murine fibroblasts. [PDF]

Virus Research
The conversion of Adenosine (A) to Inosine (I), by Adenosine Deaminases Acting on RNA or ADARs, is an essential post-transcriptional modification that contributes to proteome diversity and regulation in metazoans including humans.
Ayesha Tariq, Helen Piontkivska
doaj   +2 more sources

Biological roles of A-to-I editing: implications in innate immunity, cell death, and cancer immunotherapy [PDF]

Journal of Experimental & Clinical Cancer Research, 2023
Adenosine-to-inosine (A-to-I) editing, a key RNA modification widely found in eukaryotes, is catalyzed by adenosine deaminases acting on RNA (ADARs). Such RNA editing destabilizes endogenous dsRNAs, which are subsequently recognized by the sensors of ...
Jing Yuan, Li Xu, Hai-Juan Bao, Jie-lin Wang, Yang Zhao, Shuo Chen   +5 more
doaj   +2 more sources

Developmental stage-specific A-to-I editing pattern in the postnatal pineal gland of pigs (Sus scrofa) [PDF]

Journal of Animal Science and Biotechnology, 2020
Background RNA editing is a widespread post-transcriptional modification mechanism in mammalian genomes. Although many editing sites have been identified in domestic pigs (Sus scrofa), little is known about the characteristics and dynamic regulation of ...
Rong Zhou, Wenye Yao, Chundi Xie, Leixia Zhang, Yangli Pei, Hua Li, Zheng Feng, Yalan Yang, Kui Li   +8 more
doaj   +2 more sources

Effect of SNORD113-3/ADAR2 on glycolipid metabolism in glioblastoma via A-to-I editing of PHKA2 [PDF]

Cellular & Molecular Biology Letters
Background Glioblastoma multiforme (GBM) is a highly aggressive brain tumor, characterized by its poor prognosis. Glycolipid metabolism is strongly associated with GBM development and malignant behavior.
Zheng Cui, Xiaobai Liu, Tiange E, Hongda Lin, Di Wang, Yunhui Liu, Xuelei Ruan, Ping Wang, Libo Liu, Yixue Xue   +9 more
doaj   +2 more sources

A-to-I RNA editing: current knowledge sources and computational approaches with special emphasis on non-coding RNA molecules [PDF]

Frontiers in Bioengineering and Biotechnology, 2015
RNA editing is a dynamic mechanism for gene regulation attained through the alteration of the sequence of primary RNA transcripts. A-to-I (Adenosine-to-Inosine) RNA editing, which is catalyzed by members of the Adenosine Deaminase Acting on RNA (ADAR ...
Giovanni eNigita, Dario eVeneziano, Alfredo eFerro   +2 more
doaj   +3 more sources

LoDEI: a robust and sensitive tool to detect transcriptome-wide differential A-to-I editing in RNA-seq data [PDF]

Nature Communications
RNA editing is a highly conserved process. Adenosine deaminase acting on RNA (ADAR) mediated deamination of adenosine (A-to-I editing) is associated with human disease and immune checkpoint control. Functional implications of A-to-I editing are currently
Phillipp Torkler, Marina Sauer, Uwe Schwartz, Selim Corbacioglu, Gunhild Sommer, Tilman Heise   +5 more
doaj   +2 more sources

The Many Roles of A-to-I RNA Editing in Animals: Functional or Adaptive?

Frontiers in Bioscience-Landmark, 2023
Metazoan adenosine-to-inosine (A-to-I) RNA editing is a highly conserved mechanism that diversifies the transcriptome by post-transcriptionally converting adenosine to inosine.
Dongwu Zhan, Caiqing Zheng, Wanzhi Cai, Hu Li, Yuange Duan   +4 more
doaj   +1 more source