An essential role of KREPB4 in RNA editing and structural integrity of the editosome in Trypanosoma brucei [PDF]
, 2007 RNA editing in the sleeping sickness parasite Trypanosoma brucei remodels mitochondrial transcripts by the addition and deletion of uridylates as specified by guide RNAs.
Schnaufer, Achim; id_orcid +4 more
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Epitranscriptomic investigation of myopia-associated RNA editing in the retina
Frontiers in Neuroscience, 2023 Myopia is one of the most common causes of vision loss globally and is significantly affected by epigenetics. Adenosine-to-inosine (A-to-I RNA) editing is an epigenetic process involved in neurological disorders, yet its role in myopia remains ...
Xu-Bin Pan +24 more
doaj +1 more source
Transcriptome analysis identification of A-to-I RNA editing in granulosa cells associated with PCOS
Frontiers in Endocrinology, 2023 BackgroundPolycystic ovary syndrome (PCOS) is a complex, multifactor disorder in women of reproductive age worldwide. Although RNA editing may contribute to a variety of diseases, its role in PCOS remains unclear.MethodsA discovery RNA-Seq dataset was ...
Fan-Sheng Kong +19 more
doaj +1 more source
A-to-I editing of COG3 mRNA in bowhead muscle, kidney, liver, optical nerve and retina.
, 2021 The adenosine (*) in the ATT codon encoding I635 is subject to A-to-I editing in COG3 mRNA from all tissues analyzed (ATT = Ile to GTT = Val). In addition, the adenosine in the third position in the GAA (634) codon is only edited in liver (+).
Mads Peter Heide-Jørgensen (7869812) +1 more
core +1 more source
Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system
Frontiers in Neuroscience, 2013 The fine control of molecules mediating communication in the nervous system is key to adjusting neuronal responsiveness during development and in maintaining the stability of established networks in the face of altered sensory input.
Andrew Charles Penn +3 more
doaj +1 more source
Changes in ADAR RNA editing patterns in CMV and ZIKV congenital infections
BMC Genomics, 2023 Background RNA editing is a process that increases transcriptome diversity, often through Adenosine Deaminases Acting on RNA (ADARs) that catalyze the deamination of adenosine to inosine.
Benjamin Wales-McGrath +2 more
doaj +1 more source
Do RNA modifications contribute to modulation of immune responses in allergic diseases?
Frontiers in Allergy, 2023 RNA modifications have emerged as a fundamental mechanism of post-transcriptional gene regulation, playing vital roles in cellular physiology and the development of various diseases.
Pavel Kudrin, Ana Rebane
doaj +1 more source
RNA editing in interferonopathies
, 2021 The type I interferonopathies comprise a heterogenous group of monogenic diseases associated with a constitutive activation of type I interferon signaling.The elucidation of the genetic causes of this group of diseases revealed an alteration of nucleic ...
Michienzi A. +3 more
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An Emerging Role for isomiRs and the microRNA Epitranscriptome in Neovascularization
Cells, 2019 Therapeutic neovascularization can facilitate blood flow recovery in patients with ischemic cardiovascular disease, the leading cause of death worldwide.
Reginald V.C.T. van der Kwast +2 more
doaj +1 more source
Genome editing to the rescue: sustainably feeding 10 billion global human population [PDF]
, 2016 Modern animal breeding strategies based on population genetics, molecular tools,artificial insemination,embryo transfer and related technologies have contributed to significant increases in the performance of domestic animals, and are the basis for a ...
Whitelaw, C. B. A. +11 more
core +1 more source