New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins [PDF]
Biomolecules, 2015 The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA.
Niamh Mannion +4 more
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A loss-of-function human ADAR variant activates innate immune response and promotes bowel inflammation [PDF]
Nature CommunicationsInflammatory bowel disease (IBD) arises from genetic-environmental interactions. Adenosine deaminases acting on RNA 1 (ADAR), an RNA-editing enzyme converting adenosine (A) to inosine (I), is essential for tissue homeostasis.
Pengfei Xu +11 more
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Editome profiling and cross-cohort validation reveal A-to-I RNA editing dysregulation in the hippocampus and prefrontal cortex of sepsis patients [PDF]
Frontiers in PsychiatryIntroductionSepsis is a severe systemic inflammatory response to infection, potentially resulting in serious neurological complications. Adenosine-to-inosine (A-to-I) RNA editing is a critical epitranscriptomic process, yet its clinical involvement in ...
Jie Shen +7 more
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Zinc Finger RNA-Binding Protein Zn72D Regulates ADAR-Mediated RNA Editing in Neurons
Cell Reports, 2020 Summary: Adenosine-to-inosine RNA editing, catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes, alters RNA sequences from those encoded by DNA. These editing events are dynamically regulated, but few trans regulators of ADARs are known in vivo.
Anne L Sapiro, Amruta Bhate, Qin Li
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Adar contributes to genome integrity by regulating R-loop homeostasis in Drosophila [PDF]
BMC BiologyBackground Adenosine deaminase acting on RNA (Adar) is a critical enzyme involved in post-transcriptional epigenetic regulation through adenosine-to-inosine (A-to-I) RNA editing.
Xuedi Zhang +8 more
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Abundant A-to-I RNA editing in spermatocytes may suppress transposons to compensate for piRNA downregulation in male germlines [PDF]
RNA BiologyThe germline genome serves as a crucial battleground for transposon expansion, as transposons can increase their copy numbers in offspring when activated within germ cells.
Yuange Duan, Qiuhua Xie, Ling Ma, Qi Cao
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Dysregulation of SIRT1, polyamines and miRNA editing in cancer and aging [PDF]
Amino AcidsInterest in RNA editing has emerged in molecular medicine due to its widespread dysregulation and therapeutic potential. Its regulatory mechanisms in governing non-coding RNAs, especially microRNAs (miRNAs) remain largely unresolved. Emerging evidence in
Miora Bruna Marielle Ramamonjiharisoa +1 more
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Global Transcriptome Analysis of RNA Abundance Regulation by ADAR in Lung Adenocarcinoma
EBioMedicine, 2018 Despite tremendous advances in targeted therapies against lung adenocarcinoma, the majority of patients do not benefit from personalized treatments. A deeper understanding of potential therapeutic targets is crucial to increase the survival of patients ...
Bin Chen, Dvir Aran, Idit Kosti
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Knockdown of RNA editing proteins reshapes the HepaRG transcriptome and pharmacogene expression [PDF]
Scientific ReportsThe RNA-editing proteins ADAR and ADARB1 regulate gene expression through both editing-dependent and editing-independent mechanisms. RNA-Seq analysis of HepaRG cells after knocking down (KD) either protein caused widespread transcriptomic changes ...
Joseph M Collins +3 more
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Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing
Cell Reports, 2020 Summary: Adenosine-to-inosine RNA editing is catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes that deaminate adenosine to inosine. Although many RNA editing sites are known, few trans regulators have been identified.
Anne L Sapiro, Qin Li, James J Moresco
exaly +3 more sources