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Global Transcriptome Analysis of RNA Abundance Regulation by ADAR in Lung Adenocarcinoma
EBioMedicine, 2018 Despite tremendous advances in targeted therapies against lung adenocarcinoma, the majority of patients do not benefit from personalized treatments. A deeper understanding of potential therapeutic targets is crucial to increase the survival of patients ...
Dvir Aran, Idit Kosti, David P Carbone
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Adar contributes to genome integrity by regulating R-loop homeostasis in Drosophila [PDF]
BMC BiologyBackground Adenosine deaminase acting on RNA (Adar) is a critical enzyme involved in post-transcriptional epigenetic regulation through adenosine-to-inosine (A-to-I) RNA editing.
Xuedi Zhang +8 more
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Origins and evolution of ADAR‐mediated RNA editing [PDF]
IUBMB Life, 2009 AbstractAdenosine deaminases acting on RNA (ADARs) convert adenosines to inosines in double‐stranded RNA in animals. Identification of more ADAR targets and genome sequences of diverse eukaryotes present an opportunity to elucidate the origin and evolution of ADAR‐mediated RNA editing.
Yongfeng Jin
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Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing
Cell Reports, 2020 Summary: Adenosine-to-inosine RNA editing is catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes that deaminate adenosine to inosine. Although many RNA editing sites are known, few trans regulators have been identified.
Anne L Sapiro, Qin Li, James J Moresco
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What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs [PDF]
Open Biology, 2020 Adenosine-to-inosine (A-to-I) editing is a post-transcriptional modification of RNA which changes its sequence, coding potential and secondary structure.
Jacki E. Heraud-Farlow +1 more
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ADAR, the carcinogenesis mechanisms of ADAR and related clinical applications [PDF]
Annals of Translational Medicine, 2019 Adenosine deaminases acting on RNA (ADARs) catalyze the conversion of adenosine (A) to inosine (I) in double-stranded RNA, which can change the codons after transcription. Abnormal ADAR editing is present in a variety of cancers. However, the study of the biological effects of ADARs in cancer is not very deep.
Yue, Zhang +3 more
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Genome Biology, 2012 Adenosine to inosine (A-to-I) RNA editing is a post-transcriptional process by which adenosines are selectively converted to inosines in double-stranded RNA (dsRNA) substrates. A highly conserved group of enzymes, the adenosine deaminase acting on RNA (ADAR) family, mediates this reaction.
Savva, Yiannis A +2 more
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ANALYSIS OF FAST NEUTRON TRANSPORT IN CHLORIDE SALTS USING MONTE CARLO METHOD
Acta Polytechnica CTU Proceedings, 2020 The aim of this paper is to present results of fast neutron behavior analysis within the chloride salts environment using simulations based on Monte Carlo method (MCNP 6.2).
Ondřej Šťastný +4 more
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Heterochromatin: On the ADAR Radar? [PDF]
Current Biology, 2005 Vigilin proteins, the absence of which is known to cause abnormalities in heterochromatin, have been found to bind edited RNAs. Molecular complexes including vigilin comprise proteins involved with RNA editing and with DNA repair, making connections between these processes and RNA-based silencing mechanisms.
Fernandez, H.R. +3 more
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Identification of the pathogenic variants in three Chinese families with dyschromatosis symmetrica hereditaria [PDF]
Jichu yixue yu linchuang, 2023 Objective To analyze the clinical features and to identify the pathogenic variants in three Chinese families with dyschromatosis symmetrica hereditaria (DSH).
YANG Xueting, GUO Kexin, SUN Yang, WANG Rongrong, MA Donglai, ZHANG Xue
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