A full repertoire of Hemiptera genomes reveals a multi-step evolutionary trajectory of auto-RNA editing site in insect Adar gene [PDF]
RNA Biology, 2023 Adenosine-to-inosine (A-to-I) RNA editing, mediated by metazoan ADAR enzymes, is a prevalent post-transcriptional modification that diversifies the proteome and promotes adaptive evolution of organisms. The Drosophila Adar gene has an auto-recoding site (
Ling Ma +8 more
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Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene [PDF]
EpigeneticsAlthough A-to-I RNA editing leads to similar effects to A-to-G DNA mutation, nonsynonymous RNA editing (recoding) is believed to confer its adaptiveness by ‘epigenetically’ regulating proteomic diversity in a temporospatial manner, avoiding the ...
Caiqing Zheng +6 more
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Knockdown of RNA editing proteins reshapes the HepaRG transcriptome and pharmacogene expression [PDF]
Scientific ReportsThe RNA-editing proteins ADAR and ADARB1 regulate gene expression through both editing-dependent and editing-independent mechanisms. RNA-Seq analysis of HepaRG cells after knocking down (KD) either protein caused widespread transcriptomic changes ...
Joseph M Collins +3 more
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ADAR Regulates RNA Editing, Transcript Stability, and Gene Expression
Cell Reports, 2013 Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine, which is then recognized as guanosine. To study the role of ADAR proteins in RNA editing and gene regulation, we sequenced and compared the DNA and RNA of human B cells.
Isabel X. Wang +5 more
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Systematic analysis of A-to-I RNA editing upon release of ADAR from the nucleolus
RNA BiologyAdenosine-to-inosine (A-to-I) RNA editing, catalysed by two ADAR isoforms (p110 and p150) and ADARB1, is a critical regulatory step in gene expression.
Ruben Lattuca +3 more
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Mendelian randomization reveals DNA methylation–related pyroptosis genes associated with psoriasis risk [PDF]
Clinical EpigeneticsBackground Research has indicated a connection between pyroptosis and psoriasis, yet the specific genes involved remain largely unidentified. This study employed Mendelian randomization (MR) to evaluate the potential causal impact of both pyroptosis ...
Wenwu Dong, Cuiping Shi
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Unveiling RNA Editing by ADAR and APOBEC Protein Gene Families
Frontiers in Bioscience-LandmarkRNA editing is a crucial post-transcriptional modification that alters the transcriptome and proteome and affects many cellular processes, including splicing, microRNA specificity, stability of RNA molecules, and protein structure.
Alexander Modestov +2 more
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Identification and validation of PANoptosis-related genes in ankylosing spondylitis [PDF]
BMC Medical GenomicsAnkylosing spondylitis (AS) is a common immune inflammatory disease. PANoptosis, as a novel programmed cell death pathway, its mechanism of action in ankylosing spondylitis remains unclear.
Zhitao Shan +4 more
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Identification of the pathogenic variants in three Chinese families with dyschromatosis symmetrica hereditaria [PDF]
Jichu yixue yu linchuang, 2023 Objective To analyze the clinical features and to identify the pathogenic variants in three Chinese families with dyschromatosis symmetrica hereditaria (DSH).
YANG Xueting, GUO Kexin, SUN Yang, WANG Rongrong, MA Donglai, ZHANG Xue
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ADAR expression and copy number variation in patients with advanced gastric cancer
BMC Gastroenterology, 2020 Background Gastric cancer (GC) is a world health problem and it is the third leading cause of cancer deaths worldwide. The current practice for prognosis assessment in GC is based on radiological and pathological criteria and they may not result in an ...
Javad Behroozi +3 more
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