A full repertoire of Hemiptera genomes reveals a multi-step evolutionary trajectory of auto-RNA editing site in insect Adar gene [PDF]
RNA Biology, 2023 Adenosine-to-inosine (A-to-I) RNA editing, mediated by metazoan ADAR enzymes, is a prevalent post-transcriptional modification that diversifies the proteome and promotes adaptive evolution of organisms. The Drosophila Adar gene has an auto-recoding site (
Ling Ma +8 more
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Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene [PDF]
EpigeneticsAlthough A-to-I RNA editing leads to similar effects to A-to-G DNA mutation, nonsynonymous RNA editing (recoding) is believed to confer its adaptiveness by ‘epigenetically’ regulating proteomic diversity in a temporospatial manner, avoiding the ...
Caiqing Zheng +6 more
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Knockdown of RNA editing proteins reshapes the HepaRG transcriptome and pharmacogene expression [PDF]
Scientific ReportsThe RNA-editing proteins ADAR and ADARB1 regulate gene expression through both editing-dependent and editing-independent mechanisms. RNA-Seq analysis of HepaRG cells after knocking down (KD) either protein caused widespread transcriptomic changes ...
Joseph M Collins +3 more
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ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity [PDF]
Nature Communications, 2016 Sleep is postulated to offset buildup in net synaptic strength that occurs during waking experience. Here, the authors identify a role for the RNA editing gene Adar in regulating glutamatergic synaptic plasticity and show that disruption in ...
J. E. Robinson +3 more
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Mendelian randomization reveals DNA methylation–related pyroptosis genes associated with psoriasis risk [PDF]
Clinical EpigeneticsBackground Research has indicated a connection between pyroptosis and psoriasis, yet the specific genes involved remain largely unidentified. This study employed Mendelian randomization (MR) to evaluate the potential causal impact of both pyroptosis ...
Wenwu Dong, Cuiping Shi
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Identification and validation of PANoptosis-related genes in ankylosing spondylitis [PDF]
BMC Medical GenomicsAnkylosing spondylitis (AS) is a common immune inflammatory disease. PANoptosis, as a novel programmed cell death pathway, its mechanism of action in ankylosing spondylitis remains unclear.
Zhitao Shan +4 more
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Adar contributes to genome integrity by regulating R-loop homeostasis in Drosophila [PDF]
BMC BiologyBackground Adenosine deaminase acting on RNA (Adar) is a critical enzyme involved in post-transcriptional epigenetic regulation through adenosine-to-inosine (A-to-I) RNA editing.
Xuedi Zhang +8 more
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Systematic analysis of A-to-I RNA editing upon release of ADAR from the nucleolus [PDF]
RNA BiologyAdenosine-to-inosine (A-to-I) RNA editing, catalysed by two ADAR isoforms (p110 and p150) and ADARB1, is a critical regulatory step in gene expression.
Ruben Lattuca +3 more
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Evaluation of in vitro liver models and non-human primates for predicting ADAR RNA editing efficiency in human liver [PDF]
Scientific ReportsLiver-originated diseases remain a significant global health burden, with limited treatment options available. RNA therapeutics, particularly adenosine deaminase acting on RNA (ADAR)-mediated editing using editing oligonucleotides (EONs) offer a novel ...
Monica Aguila +8 more
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A-to-I RNA editing: current knowledge sources and computational approaches with special emphasis on non-coding RNA molecules [PDF]
Frontiers in Bioengineering and Biotechnology, 2015 RNA editing is a dynamic mechanism for gene regulation attained through the alteration of the sequence of primary RNA transcripts. A-to-I (Adenosine-to-Inosine) RNA editing, which is catalyzed by members of the Adenosine Deaminase Acting on RNA (ADAR ...
Giovanni eNigita +2 more
doaj +3 more sources