Results 21 to 30 of about 2,533,373 (163)

Gene lists in which high or moderate impact ADAR edits occur in PD gene and Lavin DE genes, per sample group.

, 2023
Gene lists in which high or moderate impact ADAR edits occur in PD gene and Lavin DE genes, per sample group.
Heather Milliken Mercer (17696765), Aiswarya Mukundan Nair (17696768), Angela Ridgel (17696771), Helen Piontkivska (36140)   +3 more
core   +1 more source

Probing ADAR-RNA Interactions for the Rational Design of Human ADAR Family-Specific Modulators [PDF]

, 2023
An important class of enzymes involved in RNA editing is the ADAR family (adenosine deaminases acting on RNA), which facilitate the deamination of adenosine (A) to inosine (I) in double-stranded RNA (dsRNA). Inosines are decoded as guanosines (G) in most
Mendoza, Herra Grajo
core   +1 more source

Recurrent encephalopathy with spinal cord involvement: An atypical manifestation of Aicardi–Goutières syndrome

Annals of Indian Academy of Neurology, 2019
Aicardi–Goutières syndrome (AGS) is a rare, genetic inflammatory disease due to mutations in any of the seven genes discovered to date (TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1).
Debopam Samanta, Raghu Ramakrishnaiah
doaj   +1 more source

Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish.

PLoS Genetics, 2015
Fragile X syndrome (FXS) is the most frequent inherited form of mental retardation. The cause for this X-linked disorder is the silencing of the fragile X mental retardation 1 (fmr1) gene and the absence of the fragile X mental retardation protein (Fmrp).
Adi Shamay-Ramot, Khen Khermesh, Hagit T Porath, Michal Barak, Yishay Pinto, Chaim Wachtel, Alona Zilberberg, Tali Lerer-Goldshtein, Sol Efroni, Erez Y Levanon, Lior Appelbaum   +10 more
doaj   +1 more source

All I's on theRADAR: role ofADARin gene regulation

, 2018
Adenosine to inosine (A‐to‐I) editing is the most abundant form of RNA modification in mammalian cells, which is catalyzed by adenosine deaminase acting on the double‐stranded RNA (ADAR) protein family. A‐to‐I editing is currently known to be involved in
Galina Shevchenko, Shevchenko, G, Kevin V. Morris, Morris, KV   +3 more
core   +1 more source

Genome-wide analysis of consistently RNA edited sites in human blood reveals interactions with mRNA processing genes and suggests correlations with cell types and biological variables

BMC Genomics, 2018
Background A-to-I RNA editing is a co−/post-transcriptional modification catalyzed by ADAR enzymes, that deaminates Adenosines (A) into Inosines (I).
Edoardo Giacopuzzi, Massimo Gennarelli, Chiara Sacco, Alice Filippini, Jessica Mingardi, Chiara Magri, Alessandro Barbon   +6 more
doaj   +1 more source

ADAR2 Protein Is Associated with Overall Survival in GBM Patients and Its Decrease Triggers the Anchorage-Independent Cell Growth Signature

Biomolecules, 2022
Background: Epitranscriptomic mechanisms, such as A-to-I RNA editing mediated by ADAR deaminases, contribute to cancer heterogeneity and patients’ stratification.
Valeriana Cesarini, Domenico Alessandro Silvestris, Federica Galeano, Valentina Tassinari, Maurizio Martini, Franco Locatelli, Angela Gallo   +6 more
doaj   +1 more source

Proteotranscriptomics of ocular adnexal B-cell lymphoma reveals an oncogenic role of alternative splicing and identifies a diagnostic marker

Journal of Experimental & Clinical Cancer Research, 2022
Background Ocular adnexal B-cell lymphoma (OABL) is a rare subtype of non-Hodgkin lymphoma. The molecular characteristics of OABL remain poorly understood.
Jiahao Shi, Tianyu Zhu, Huimin Lin, Zhen Liu, Min Zhou, Ziyao Yu, Xiaowen Zhou, Xin Song, Yefei Wang, Renbing Jia, Xianqun Fan, Yixiong Zhou   +11 more
doaj   +1 more source

RNA editing of the 5-HT2C receptor in the central nucleus of the amygdala is involved in resilience behavior

Translational Psychiatry, 2021
Post-traumatic-stress-disorder (PTSD) is a stress-related condition that may develop after exposure to a severe trauma-event. One of the core brain areas that is considered to be a key regulatory region of PTSD is the amygdala.
Gal Warhaftig, Chaya Mushka Sokolik, Khen Khermesh, Yehuda Lichtenstein, Michal Barak, Tzofnat Bareli, Erez Y. Levanon, Gal Yadid   +7 more
doaj   +1 more source

Gene-Based Therapeutics for Inherited Retinal Diseases

Frontiers in Genetics, 2022
Inherited retinal diseases (IRDs) are a heterogenous group of orphan eye diseases that typically result from monogenic mutations and are considered attractive targets for gene-based therapeutics.
Beau J. Fenner, Beau J. Fenner, Beau J. Fenner, Tien-En Tan, Tien-En Tan, Tien-En Tan, Amutha Veluchamy Barathi, Sai Bo Bo Tun, Sia Wey Yeo, Andrew S. H. Tsai, Andrew S. H. Tsai, Andrew S. H. Tsai, Shu Yen Lee, Shu Yen Lee, Shu Yen Lee, Chui Ming Gemmy Cheung, Chui Ming Gemmy Cheung, Chui Ming Gemmy Cheung, Choi Mun Chan, Choi Mun Chan, Choi Mun Chan, Jodhbir S. Mehta, Jodhbir S. Mehta, Jodhbir S. Mehta, Jodhbir S. Mehta, Jodhbir S. Mehta, Kelvin Y. C. Teo, Kelvin Y. C. Teo, Kelvin Y. C. Teo   +28 more
doaj   +1 more source