Results 1 to 10 of about 4,773 (159)

ADAR1 regulates vascular remodeling in hypoxic pulmonary hypertension through N1-methyladenosine modification of circCDK17

Acta Pharmaceutica Sinica B, 2023
Pulmonary hypertension (PH) is an extremely malignant pulmonary vascular disease of unknown etiology. ADAR1 is an RNA editing enzyme that converts adenosine in RNA to inosine, thereby affecting RNA expression. However, the role of ADAR1 in PH development
Junting Zhang, Yuan Chen, Xusheng Yang   +2 more
exaly   +3 more sources

ADAR1 Alleviates Inflammation in a Murine Sepsis Model via the ADAR1-miR-30a-SOCS3 Axis

Mediators of Inflammation, 2020
Adenosine deaminase acting on double-stranded RNA 1 (ADAR1) mediates adenosine-to-inosine (A-to-I) RNA editing events. ADAR1 is highly expressed in “septic” macrophages and in small intestinal tissues of mice with sepsis.
Zhou Shangxun, Li Junjie, Zhao Wei, Wang Yutong, Jia Wenyuan, Liu Shanshou, Wang Yanjun, Wang Qianmei, Feng Zhusheng, Yu Chaoping, Zhuang Ran, Yin Wen, Huang Yang   +12 more
doaj   +3 more sources

ADAR1: a central regulator of dsRNA sensing in host-virus interactions [PDF]

Frontiers in Immunology
Adenosine deaminase acting on RNA 1 (ADAR1) is a key regulator of RNA homeostasis and innate immunity through its adenosine-to-inosine (A-to-I) editing of double-stranded RNAs (dsRNAs).
Congnuan Liu, Younho Choi
doaj   +2 more sources

The role of ADAR1 in human pathophysiology. [PDF]

Front Cell Dev Biol
Adenosine deaminase 1 (ADAR1) is an enzyme acting on double-stranded RNA, primarily responsible for catalyzing the adenosine-inosine deamination reaction of dsRNA.An increasing number of studies have demonstrated that ADAR1 plays a pivotal role in various diseases, including cardiovascular, neurological, and immune disorders, among others.
Li J, Xiao Y, Li X, Dai Y.
europepmc   +4 more sources

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells [PDF]

Advanced Science
Functional exhaustion and inefficient tumor infiltration rates limit the effectiveness of natural killer (NK) cell‐based cancer immunotherapy. Although the role of adenosine deaminase acting on RNA 1 (ADAR1) in immune cells and tumorigenesis is gradually
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
doaj   +2 more sources

ZYS-1 is not an ADAR1 inhibitor. [PDF]

RNA
Abstract Adenosine deaminase acting on RNA 1 (ADAR1) edits double-stranded RNA (dsRNA) substrates by the deamination of adenosine to inosine in a process known as A-to-I editing. Modulation of ADAR1 expression and editing activity has previously been described to play a role in cancer development and progression, with upregulation of ...
Smoak CN, Gardner EN, Chua RN, Cottrell KA.   +3 more
europepmc   +4 more sources

Role of ADAR1 on Proliferation and Differentiation in Porcine Preadipocytes

Animals
Recent research has identified ADAR1 as a participant in the regulation of lipid accumulation in mice. However, there are no reports on the roles of ADAR1 in proliferation, apoptosis and differentiation of porcine preadipocytes.
Menghuan Yang, Jun Jiang, Ruimin Ren, Ning Gao, Jun He, Yuebo Zhang   +5 more
doaj   +3 more sources

ADAR1: from basic mechanisms to inhibitors

Trends in Cell Biology
Adenosine deaminase acting on RNA 1 (ADAR1) converts adenosine to inosine in double-stranded RNA (dsRNA) molecules, a process known as A-to-I editing. ADAR1 deficiency in humans and mice results in profound inflammatory diseases characterised by the spontaneous induction of innate immunity.
Parinaz Mehdipour, Jan Rehwinkel
exaly   +3 more sources

ADAR1 exacerbates ischemic brain injury via astrocyte-mediated neuron apoptosis

Redox Biology, 2023
Astrocytes affect stroke outcomes by acquiring functionally dominant phenotypes. Understanding molecular mechanisms dictating astrocyte functional status after brain ischemia/reperfusion may reveal new therapeutic strategies.
Dunpeng Cai, Ken Fujise, Shi-You Chen
exaly   +3 more sources

In Silico Characterization of ADAR1: Structure, Dynamics, and Functional Implications. [PDF]

Curr Issues Mol Biol
Adenosine deaminase acting on RNA 1 (ADAR1) is an essential RNA-editing enzyme responsible for the hydrolytic deamination of adenosine to inosine (A-to-I) in double-stranded RNA. This editing mechanism plays a critical role in gene regulation, particularly in neural and immune contexts.
Ashley CN, Broni E, Wood CM, Miller WA.
europepmc   +4 more sources