Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer [PDF]
Advanced ScienceADAR1‐mediated RNA editing has been implicated in tumor immune evasion, primarily through tumor‐intrinsic interferon (IFN) signaling. However, its cell‐type‐specific roles within immune compartments, particularly T cells, remain unclear in colorectal ...
Da Kang +10 more
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Neuron-specific deletion of ADAR1 induces brain malformation and early postnatal lethality [PDF]
Journal of NeuroinflammationAdenosine deaminase acting on RNA 1 (ADAR1), which mediates adenosine-to-inosine RNA editing, is expressed as two isoforms, p110 and p150. Deletion of Adar1 p150 in mice results in embryonic lethality caused by aberrant activation of melanoma ...
Hiroyuki Todo +5 more
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All-trans retinoic acid destabilizes ADAR1 protein through retinoylation-mediated USP7 dissociation and improves immunotherapy in pancreatic cancer [PDF]
Nature CommunicationsAdenosine deaminase acting on RNA 1 (ADAR1) contributes to immunotherapy resistance by suppressing interferon signaling. Therapeutic targeting of ADAR1 has not been achieved to date in clinical settings.
Ching-Fei Li +26 more
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ADAR1: a central regulator of dsRNA sensing in host-virus interactions [PDF]
Frontiers in ImmunologyAdenosine deaminase acting on RNA 1 (ADAR1) is a key regulator of RNA homeostasis and innate immunity through its adenosine-to-inosine (A-to-I) editing of double-stranded RNAs (dsRNAs).
Congnuan Liu, Younho Choi
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ADAR1 exacerbates ischemic brain injury via astrocyte-mediated neuron apoptosis
Redox Biology, 2023 Astrocytes affect stroke outcomes by acquiring functionally dominant phenotypes. Understanding molecular mechanisms dictating astrocyte functional status after brain ischemia/reperfusion may reveal new therapeutic strategies.
Shi-You Chen, Ken Fujise, Dunpeng Cai
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Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells [PDF]
Advanced ScienceFunctional exhaustion and inefficient tumor infiltration rates limit the effectiveness of natural killer (NK) cell‐based cancer immunotherapy. Although the role of adenosine deaminase acting on RNA 1 (ADAR1) in immune cells and tumorigenesis is gradually
Shuhan Chen +11 more
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Acta Pharmaceutica Sinica B, 2023 Pulmonary hypertension (PH) is an extremely malignant pulmonary vascular disease of unknown etiology. ADAR1 is an RNA editing enzyme that converts adenosine in RNA to inosine, thereby affecting RNA expression. However, the role of ADAR1 in PH development
Junting Zhang +11 more
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PLoS Genetics, 2021 Adenosine deaminase acting on RNA 1 (ADAR1), an enzyme responsible for adenosine-to-inosine RNA editing, is composed of two isoforms: nuclear p110 and cytoplasmic p150.
Jung In Kim +11 more
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ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation
Frontiers in Endocrinology, 2022 IntroductionEnterovirus infection has long been suspected as a possible trigger for type 1 diabetes. Upon infection, viral double-stranded RNA (dsRNA) is recognized by membrane and cytosolic sensors that orchestrate type I interferon signaling and the ...
Florian Szymczak +9 more
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Expression and clinical significance of adenosine deaminase acting on RNA-1 in lung adenocarcinoma
Di-san junyi daxue xuebao, 2021 Objective To investigate the expression of adenosine deaminase acting on RNA-1 (ADAR1) in lung adenocarcinoma and its association with clinicopathological characteristics and prognosis.
YANG Wendi +4 more
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