Results 31 to 40 of about 4,773 (159)
ADAR1: A New Target for Immuno-oncology Therapy [PDF]
Molecular Cell, 2019 Three recent studies by Ishizuka et al. (2019), Liu et al. (2019), and Gannon et al. (2018) show that deleting RNA editing enzyme ADAR1 could induce higher cell lethality and render tumor cells more vulnerable to immunotherapy, pinpointing ADAR1 as a new immuno-oncology target.
Amruta, Bhate, Tao, Sun, Jin Billy, Li
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Biochemical Genetics, 2023 Abstract Background Aicardi-Goutières syndrome 6 (AGS6) is a serious auto immunization-associated acute neurologic decompensation. AGS6 manifests as acute onset of severe generalized dystonia of limbs and developmental regression secondary to febrile illness mostly.
Xiangyu Liu +7 more
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Adenosine deaminase acting on RNA-1 (ADAR1) inhibits HIV-1 replication in human alveolar macrophages. [PDF]
PLoS ONE, 2014 While exploring the effects of aerosol IFN-γ treatment in HIV-1/tuberculosis co-infected patients, we observed A to G mutations in HIV-1 envelope sequences derived from bronchoalveolar lavage (BAL) of aerosol IFN-γ-treated patients and induction of ...
Michael D Weiden +10 more
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ADAR1-Mediated RNA Editing and Its Role in Cancer
Frontiers in Cell and Developmental Biology, 2022 It is well known that the stability of RNA, the interaction between RNA and protein, and the correct translation of protein are significant forces that drive the transition from normal cell to malignant tumor.
Jizhe Liu +10 more
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ADAR1 Is Involved in the Development of Microvascular Lung Injury [PDF]
Circulation Research, 2001 Abstract —Deamination of adenosine on pre-mRNA to inosine is a recently discovered process of posttranscription modification of pre-mRNA, termed A-to-I RNA editing, which results in the production of proteins not inherent in the genome.
R, Rabinovici +6 more
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RNA editing by ADAR1 marks dsRNA as “self” [PDF]
Cell Research, 2015 A paper recently published in Science reports that adenosine deaminase acting on RNA 1-dependent adenosine-to-inosine editing marks endogenous double strand RNA as self and prevents their immune recognition by cytosolic RNA sensor MDA5.
Zhou, Yu, Taoyong, Chen, Xuetao, Cao
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Roles of miR-432 and circ_0000418 in mediating the anti-depressant action of ADAR1
Neurobiology of Stress, 2021 Adenosine deaminase acting on RNA1 (ADAR1) is a newly discovered epigenetic molecule marker that is sensitive to environmental stressors. A recent study has demonstrated that ADAR1 affects BDNF expression via miR-432 and is involved in antidepressant ...
Xiaonan Zhang +12 more
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RNA Editing, ADAR1, and the Innate Immune Response [PDF]
Genes, 2017 RNA editing, particularly A-to-I RNA editing, has been shown to play an essential role in mammalian embryonic development and tissue homeostasis, and is implicated in the pathogenesis of many diseases including skin pigmentation disorder, autoimmune and inflammatory tissue injury, neuron degeneration, and various malignancies.
Wang, Qingde +3 more
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An essential role of adenosine deaminase acting on RNA 1 in coeliac disease mucosa
Frontiers in Immunology, 2023 Background and aimType I interferons (IFNs) are highly expressed in the gut mucosa of celiac disease (CD) gut mucosa and stimulates immune response prompted by gluten ingestion, but the processes that maintain the production of these inflammatory ...
Davide Di Fusco +14 more
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Diabetes, Metabolic Syndrome and Obesity, 2022 Hongli Yang,1,* Fajuan Rui,2,* Rui Li,3,* Shengxia Yin,4 Qi Xue,1 Xinyu Hu,5 Yayun Xu,5 Chao Wu,4 Junping Shi,6 Jie Li2,4 1Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji’nan ...
Yang H +9 more
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