Results 31 to 40 of about 4,973 (174)
ADAR1 is a prognostic biomarker and is correlated with immune infiltration in lung adenocarcinoma
Cancer Medicine, 2023 Background Lung adenocarcinoma (LUAD) is a common subtype of non‐small cell lung cancer with high morbidity and mortality rates and is usually detected at advanced stages because of the early onset of metastasis. Adenosine deaminase RNA‐specific 1 (ADAR1)
Wendi Yang +7 more
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Antagonistic and stimulative roles of ADAR1 in RNA silencing [PDF]
RNA Biology, 2013 Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosine residues to inosine specifically in double-stranded RNAs (dsRNA). This A-to-I RNA editing pathway and the RNA interference (RNAi) pathway seem to interact antagonistically by competing for their common dsRNA substrates. For instance, A-to-I editing of certain
Kazuko, Nishikura +3 more
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Scientific Reports, 2023 Adenosine-to-inosine RNA editing is a process mediated by adenosine deaminases that act on the RNA (ADAR) gene family. It has been discovered recently as an epigenetic modification dysregulated in human cancers.
Nanako Hata +19 more
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Biochemical Genetics, 2023 Abstract Background Aicardi-Goutières syndrome 6 (AGS6) is a serious auto immunization-associated acute neurologic decompensation. AGS6 manifests as acute onset of severe generalized dystonia of limbs and developmental regression secondary to febrile illness mostly.
Xiangyu Liu +7 more
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A new function for the RNA-editing enzyme ADAR1 [PDF]
Nature Immunology, 2009 ADAR1 catalyzes the deamination of adenosine to inosine in double-stranded RNA. This RNA-editing enzyme is now shown to be involved in hematopoiesis, where it acts to suppress interferon signaling and to block premature apoptosis.
Hisashi, Iizasa, Kazuko, Nishikura
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Roles of miR-432 and circ_0000418 in mediating the anti-depressant action of ADAR1
Neurobiology of Stress, 2021 Adenosine deaminase acting on RNA1 (ADAR1) is a newly discovered epigenetic molecule marker that is sensitive to environmental stressors. A recent study has demonstrated that ADAR1 affects BDNF expression via miR-432 and is involved in antidepressant ...
Xiaonan Zhang +12 more
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ADAR1: A New Target for Immuno-oncology Therapy [PDF]
Molecular Cell, 2019 Three recent studies by Ishizuka et al. (2019), Liu et al. (2019), and Gannon et al. (2018) show that deleting RNA editing enzyme ADAR1 could induce higher cell lethality and render tumor cells more vulnerable to immunotherapy, pinpointing ADAR1 as a new immuno-oncology target.
Amruta, Bhate, Tao, Sun, Jin Billy, Li
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Diabetes, Metabolic Syndrome and Obesity, 2022 Hongli Yang,1,* Fajuan Rui,2,* Rui Li,3,* Shengxia Yin,4 Qi Xue,1 Xinyu Hu,5 Yayun Xu,5 Chao Wu,4 Junping Shi,6 Jie Li2,4 1Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji’nan ...
Yang H +9 more
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ZYS-1 is not an ADAR1 inhibitor
RNAAbstract Adenosine deaminase acting on RNA 1 (ADAR1) edits double-stranded RNA (dsRNA) substrates by the deamination of adenosine to inosine in a process known as A-to-I editing. Modulation of ADAR1 expression and editing activity has previously been described to play a role in cancer development and progression, with upregulation of ...
Cassandra N. Smoak +3 more
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Adenosine deaminase acting on RNA-1 (ADAR1) inhibits HIV-1 replication in human alveolar macrophages. [PDF]
PLoS ONE, 2014 While exploring the effects of aerosol IFN-γ treatment in HIV-1/tuberculosis co-infected patients, we observed A to G mutations in HIV-1 envelope sequences derived from bronchoalveolar lavage (BAL) of aerosol IFN-γ-treated patients and induction of ...
Michael D Weiden +10 more
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