Results 51 to 60 of about 4,773 (159)

RNA editing by ADAR1 regulates innate and antiviral immune functions in primary macrophages

Scientific Reports, 2017
ADAR1-dependent A-to-I editing has recently been recognized as a key process for marking dsRNA as self, therefore, preventing innate immune activation and affecting the development and resolution of immune-mediated diseases and infections.
Maria Pujantell, Eva Riveira-Muñoz, Roger Badia, Marc Castellví, Edurne Garcia-Vidal, Guillem Sirera, Teresa Puig, Cristina Ramirez, Bonaventura Clotet, José A. Esté, Ester Ballana   +10 more
doaj   +1 more source

ADAR1 isoform involvement in embryonic lethality [PDF]

Proceedings of the National Academy of Sciences, 2011
Letters to the editor recently published in PNAS (1, 2) challenged and defended a claim made on a recent article (3). Matthaei et al. (1) questioned whether the animal model used by Ward et al. (3) was adequate to support their claim that the P150 isoform of the RNA editing enzyme adenosine deaminase 1 (ADAR1) is required for embryogenesis.
Richard A. Steinman, Qingde Wang
openaire   +1 more source

Suppression of A-to-I RNA-editing enzyme ADAR1 sensitizes hepatocellular carcinoma cells to oxidative stress through regulating Keap1/Nrf2 pathway

Experimental Hematology & Oncology
Background A-to-I RNA editing is an abundant post-transcriptional modification event in hepatocellular carcinoma (HCC). Evidence suggests that adenosine deaminases acting on RNA 1 (ADAR1) correlates to oxidative stress that is a crucial factor of HCC ...
Houhong Wang, Xiaoyu Wei, Lu Liu, Junfeng Zhang, Heng Li   +4 more
doaj   +1 more source

ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation

Nature, 2022
The RNA-editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) limits the accumulation of endogenous immunostimulatory double-stranded RNA (dsRNA)1. In humans, reduced ADAR1 activity causes the severe inflammatory disease Aicardi-Goutières syndrome (AGS)2. In mice, complete loss of ADAR1 activity is embryonically lethal3-6, and mutations similar to
Richard de Reuver, Simon Verdonck, Evelien Dierick, Josephine Nemegeer, Eline Hessmann, Sadeem Ahmad, Maude Jans, Gillian Blancke, Filip Van Nieuwerburgh, Alexander Botzki, Lars Vereecke, Geert van Loo, Wim Declercq, Sun Hur, Peter Vandenabeele, Jonathan Maelfait   +15 more
openaire   +2 more sources

RNA editing enzyme ADAR1 is required for early T cell development

Blood Science, 2020
. The RNA editing enzyme ADAR1 has been shown to be an essential molecule for hematopoietic cell differentiation, embryonic development, and regulation of immune responses.
Richard Xufeng, Daibang Nie, Qiong Yang, Wang Wang, Tao Cheng, Qingde Wang   +5 more
doaj   +1 more source

ADAR1 overexpression is associated with cervical cancer progression and angiogenesis [PDF]

Diagnostic Pathology, 2017
This study aimed to assess the role of RNA-dependent adenosine deaminase (ADAR1) in cervical squamous cell carcinoma occurrence and progression.ADAR1 expression levels in stage IA and stage IIA cervical squamous cell carcinoma (group A), cervical intraepithelial neoplasia (CIN) specimens (group B), as well as normal and inflamed cervical tissue samples
Chen, Ying, Wang, He, Lin, Wenyi, Shuai, Ping   +3 more
openaire   +2 more sources

ADAR1 expression is associated with tumour-infiltrating lymphocytes in triple-negative breast cancer

Tumor Biology, 2017
Tumours with a high mutation burden exhibit considerable neoantigens and tumour-infiltrating lymphocytes. RNA editing by ADAR1 is a source of changes in epitope.
In Hye Song, Young-Ae Kim, Sun-Hee Heo, In Ah Park, Miseon Lee, Won Seon Bang, Hye Seon Park, Gyungyub Gong, Hee Jin Lee   +8 more
doaj   +1 more source

The majority of A-to-I RNA editing is not required for mammalian homeostasis

Genome Biology, 2019
Background Adenosine-to-inosine (A-to-I) RNA editing, mediated by ADAR1 and ADAR2, occurs at tens of thousands to millions of sites across mammalian transcriptomes.
Alistair M. Chalk, Scott Taylor, Jacki E. Heraud-Farlow, Carl R. Walkley   +3 more
doaj   +1 more source

Mutations in ADAR1, IFIH1, and RNASEH2B Presenting As Spastic Paraplegia

Neuropediatrics, 2014
Hereditary spastic paraplegia is a neurodegenerative phenotype characterized by a progressive loss of corticospinal motor tract function. In a majority of affected individuals the pathogenesis remains undetermined.We identified a series of patients with a phenotype of nonsyndromic spastic paraplegia in whom no diagnosis had been reached before exome ...
Crow, Yanick J, Zaki, Maha S, Abdel-Hamid, Mohamed S, Abdel-Salam, Ghada, Boespflug-Tanguy, Odile, Cordeiro, Nuno J V, Gleeson, Joseph G, Gowrinathan, Nirmala Rani, Laugel, Vincent, Renaldo, Florence, Rodriguez, Diana, Livingston, John H, Rice, Gillian I   +12 more
openaire   +3 more sources

Effect of interferons on expression of adenosine deaminase acting on RNA 1 and hepatitis B virus replication in human hepatocellular carcinoma cells in vitro

Di-san junyi daxue xuebao, 2019
Objective To investigate the effect of type Ⅰ interferons (IFN-α and IFN-β) and type Ⅱ interferon (IFN-γ) on the expression of adenosine deaminase acting on RNA 1 (ADAR1, P110 and P150) and hepatitis B virus (HBV) replication in hepatocellular carcinoma (
LI Yimin, LI Yimin, YUAN Lin, YUAN Lin, YANG Shengyong   +4 more
doaj   +1 more source