Results 71 to 80 of about 8,092 (217)

In vivo RNA editing of point mutations via RNA-guided adenosine deaminases. [PDF]

, 2019
We present in vivo sequence-specific RNA base editing via adenosine deaminases acting on RNA (ADAR) enzymes with associated ADAR guide RNAs (adRNAs). To achieve this, we systematically engineered adRNAs to harness ADARs, and comprehensively evaluated the
Chen, Genghao, Ganesh, Ashwin, Katrekar, Dhruva, Mali, Prashant, Meluzzi, Dario, Shih, Yu-Ru, Varghese, Shyni, Worlikar, Atharv   +7 more
core   +1 more source

Proteins that contain a functional Z-DNA-binding domain localize to cytoplasmic stress granules [PDF]

, 2013
Long double-stranded RNA may undergo hyper-editing by adenosine deaminases that act on RNA (ADARs), where up to 50% of adenosine residues may be converted to inosine.
Ng, Siew Kit, Ronson, George E., Scadden, A. D. J., Weissbach, Rebekka   +3 more
core   +1 more source

Liquid–Liquid Phase Separation in Viral Infection and Immunology

MedComm, Volume 7, Issue 4, April 2026.
LLPS organizes viral replication and antiviral immunity. Viruses hijack LLPS to form replication factories and evade immune sensors, while hosts assemble LLPS‐driven signaling hubs (e.g., MAVS, RIG‐I, and SGs) to amplify interferon responses. Targeting these condensate interfaces offers novel therapeutic strategies against infectious diseases ...
Jiuzhi Xu, Lan Bai, Bin Wang, Hai Song, Long Zhang, Fangfang Zhou   +5 more
wiley   +1 more source

ADAR1 silencing-induced HUVEC apoptosis is mediated by FGFR2 under hypoxia stress

Drug Design, Development and Therapy, 2018
Yun Jiang,1 Zhancheng Wang,1 Xu Chen,1 Wei Wang,1 Xiaowei Wang2 1Department of Cardiology, The Eighth People’s Hospital of Shanghai, Shanghai 200233, China; 2Shanghai Weiang Info Tech Ltd., Shanghai 200233, China Background: The adenosine ...
Jiang Y, Wang Z, Chen X, Wang W, Wang X
doaj  

Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis [PDF]

, 2018
Background Paraspeckles are subnuclear bodies assembled on a long non-coding RNA (lncRNA) NEAT1. Their enhanced formation in spinal neurons of sporadic amyotrophic lateral sclerosis (ALS) patients has been reported but underlying mechanisms are unknown ...
Tatyana A. Shelkovnikova, Michail S. Kukharsky, Haiyan An, Pasquale Dimasi, Svetlana Alexeeva, Osman Shabir, Paul R. Heath, Vladimir L. Buchman, AE Renton, M DeJesus-Hernandez, J Sreedharan, S Lattante, M Neumann, T Arai, AH Fox, T Naganuma, CM Clemson, S Hennig, H Sunwoo, T Hirose, K Imamura, Z Zhang, L Jiang, H Choudhry, D Chakravarty, C Adriaens, Y Nishimoto, S Nakagawa, S Thomas-Jinu, TA Shelkovnikova, A Chesi, HJ Kim, JR Tollervey, M Polymenidou, MS Kukharsky, L Cong, TA Shelkovnikova, AE Renton, Y Kawahara, E Buratti, H Ota, M Morlando, GS Tan, C Lagier-Tourenne, TK Saldi, E White, SR Heras, BJ Liddicoat, F Weber, H Kaneko, M Marullo, SJ Marciniak, GJ Seo, LL Chen, S Melo, G Shan, A Emde, IE Schor, T Misteli, T Yamazaki, C Figueroa-Romero, A Freischmidt, E Gascon, EF Goodall, C Eitan, D Campos-Melo, S Bottini, A Heyam, V Tarallo, NM Mannion, A Ruggieri, S Porta, W Li, TP Hurst, KB Chiappinelli, RA Elbarbary, G Barry, F Zhang, JA West   +78 more
core   +3 more sources

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

RNA editing by ADAR1 regulates innate and antiviral immune functions in primary macrophages

Scientific Reports, 2017
ADAR1-dependent A-to-I editing has recently been recognized as a key process for marking dsRNA as self, therefore, preventing innate immune activation and affecting the development and resolution of immune-mediated diseases and infections.
Maria Pujantell, Eva Riveira-Muñoz, Roger Badia, Marc Castellví, Edurne Garcia-Vidal, Guillem Sirera, Teresa Puig, Cristina Ramirez, Bonaventura Clotet, José A. Esté, Ester Ballana   +10 more
doaj   +1 more source

The influence of CpG and UpA dinucleotide frequencies on RNA virus replication and characterization of the innate cellular pathways underlying virus attenuation and enhanced replication [PDF]

, 2014
Most RNA viruses infecting mammals and other vertebrates show profound suppression of CpG and UpA dinucleotide frequencies. To investigate this functionally, mutants of the picornavirus, echovirus 7 (E7), were constructed with altered CpG and UpA ...
Atkinson, Nicky J., Evans, David J., Simmonds, Peter, Witteveldt, Jeroen   +3 more
core   +2 more sources

When R‐Loops Go Awry: Genome Instability and Neurological Diseases

European Journal of Neuroscience, Volume 63, Issue 8, April 2026.
DNA normally exists as a double helix formed by two complementary strands. During gene transcription, however, one strand of DNA can bind to RNA, causing the other DNA strand to be displaced. This creates a structure called an R‐loop. R‐loops play important roles in normal cellular processes such as gene expression, DNA replication, and transcription ...
Nur Rasyiqin Rasli, Yu Katsuyama
wiley   +1 more source

Suppression of A-to-I RNA-editing enzyme ADAR1 sensitizes hepatocellular carcinoma cells to oxidative stress through regulating Keap1/Nrf2 pathway

Experimental Hematology & Oncology
Background A-to-I RNA editing is an abundant post-transcriptional modification event in hepatocellular carcinoma (HCC). Evidence suggests that adenosine deaminases acting on RNA 1 (ADAR1) correlates to oxidative stress that is a crucial factor of HCC ...
Houhong Wang, Xiaoyu Wei, Lu Liu, Junfeng Zhang, Heng Li   +4 more
doaj   +1 more source