Results 71 to 80 of about 4,773 (159)

ADAR1 Promotes Myogenic Proliferation and Differentiation of Goat Skeletal Muscle Satellite Cells

Cells
As one of the most important economic traits for domestic animal husbandry, skeletal muscle is regulated by an intricate molecular network. Adenosine deaminase acting on RNA (ADAR1) involves various physiological processes and diseases, such as innate ...
Zihao Zhao, Miao Xiao, Xiaoli Xu, Meijun Song, Dinghui Dai, Siyuan Zhan, Jiaxue Cao, Jiazhong Guo, Tao Zhong, Linjie Wang, Li Li, Hongping Zhang   +11 more
doaj   +1 more source

ADAR1 Is Essential for Smooth Muscle Homeostasis and Vascular Integrity

Cells
Vascular smooth muscle cells (VSMCs) play a critical role in maintaining vascular integrity. VSMC dysfunction leads to numerous vascular diseases. Adenosine deaminases acting on RNA 1 (ADAR1), an RNA editing enzyme, has shown both RNA editing and non-editing functions. Global deletion of ADAR1 causes embryonic lethality, but the phenotype of homozygous
Dunpeng Cai, Shi-You Chen
openaire   +3 more sources

Dimerization of ADAR1 modulates site-specificity of RNA editing

Nature Communications
Adenosine-to-inosine editing is catalyzed by adenosine deaminases acting on RNA (ADARs) in double-stranded RNA (dsRNA) regions. Although three ADARs exist in mammals, ADAR1 is responsible for the vast majority of the editing events and acts on thousands ...
Allegra Mboukou, Vinod Rajendra, Serafina Messmer, Therese C. Mandl, Marjorie Catala, Carine Tisné, Michael F. Jantsch, Pierre Barraud   +7 more
doaj   +1 more source

ADAR1 p150 prevents HSV-1 from triggering PKR/eIF2α-mediated translational arrest and is required for efficient viral replication.

PLoS Pathogens
Adenosine deaminase acting on dsRNA 1 (ADAR1) catalyzes the deamination of adenosines to inosines in double-stranded RNAs (dsRNA) and regulates innate immunity by preventing the hyperactivation of cytosolic dsRNA sensors such as MDA5, PKR or ZBP1.
Adwait Parchure, Mia Cesarec, Antonija Braut, Robert Kolman, Vlatka Ivanišević, Marina Čunko, Slađana Bursać, Richard de Reuver, Antonija J Begonja, Umberto Rosani, Siniša Volarević, Jonathan Maelfait, Igor Jurak   +12 more
doaj   +1 more source

High-speed atomic force microscopy and 3D modeling reveal the structural dynamics of ADAR1 complexes

Nature Communications
Targeting abnormal dysregulation of adenosine-to-inosine deamination by ADAR enzymes offers a promising therapeutic strategy in cancer research. However, the development of effective inhibitors is impeded by the incomplete structural information on ADAR1
Madhu Biyani, Yasuhiro Isogai, Kirti Sharma, Shoei Maeda, Hinako Akashi, Yui Sugai, Masataka Nakano, Noriyuki Kodera, Manish Biyani, Miki Nakajima   +9 more
doaj   +1 more source

RNA editing regulates host immune response and T cell homeostasis in SARS-CoV-2 infection.

PLoS ONE
Adenosine to inosine (A-to-I) RNA editing by ADAR1 has been implicated in maintaining self-tolerance, preventing autoimmunity, and mediating antiviral immunity.
Molly Huang, Adam Mark, Jessica Pham, Karina Vera, Amanda M Saravia-Butler, Afshin Beheshti, Qingfei Jiang, Kathleen M Fisch   +7 more
doaj   +1 more source

Predictive marker for response to trifluridine/tipiracil plus bevacizumab in metastatic colorectal cancer patients

BMC Cancer
Objective Trifluridine/tipiracil (FTD/TPI) is one of the options for late-line treatment of colorectal cancer (CRC). However, the specific patient populations that would particularly benefit from it remain unclear.
Toshiaki Takahashi, Kunitoshi Shigeyasu, Yoshitaka Kondo, Sho Takeda, Hibiki Umeda, Kazuya Moriwake, Masashi Kayano, Yuya Sakurai, Shunsuke Nakamura, Masafumi Takahashi, Kaori Nitta, Kazuhiro Yoshida, Yuki Matsumi, Hiroyuki Michiue, Hideki Yamamoto, Hiroyuki Kishimoto, Fuminori Teraishi, Ryohei Shoji, Nobuhiko Kanaya, Hajime Kashima, Yoshihiko Kakiuchi, Shinji Kuroda, Shunsuke Kagawa, Toshiyoshi Fujiwara   +23 more
doaj   +1 more source

ADAR1 expression is associated with cervical cancer progression and negatively regulates NK cell activity

JCI Insight
ADAR1 edits double-stranded RNAs (dsRNAs) by deaminating adenosines into inosines, preventing aberrant activation of innate immunity by endogenous dsRNAs, which may resemble viral structures.
Valentina Tassinari, Marta Kaciulis, Stefano Petrai, Helena Stabile, Angelina Pernazza, Martina Leopizzi, Valeria Di Maio, Francesca Belleudi, Danilo Ranieri, Vanessa Mancini, Innocenza Palaia, Federica Tanzi, Ludovica Lospinoso Severini, Silvia Ruggeri, Maria Emanuela Greco, Giovanni Bernardini, Alessandra Zingoni, Marco Cippitelli, Cristina Cerboni, Alessandra Soriani   +19 more
doaj   +1 more source

The anti-apoptotic function of ADAR1 [PDF]

Nature Reviews Molecular Cell Biology, 2017
openaire   +1 more source

Z-nucleic acid-mediated PANoptosis in infection, inflammation, and cancer. [PDF]

Commun Biol
Thapa N, Kim A, Patel P, Nguyen MQ, Lee E, Karki R.   +5 more
europepmc   +1 more source