Results 71 to 80 of about 4,973 (174)

Quantitative Control of Transposable Elements: From Genome Plasticity to Immune Regulatory Circuits

Cell Biochemistry and Function, Volume 44, Issue 7, July 2026.
ABSTRACT Transposable elements (TEs) constitute nearly half of the human genome and are increasingly recognized as context‐dependent regulators of genome function rather than passive repetitive DNA. This Review synthesizes classical and recent evidence on TE biology, including TE classification, mechanisms of mobilization, host restriction pathways ...
Irving Jesús Reyes‐Barragán
wiley   +1 more source

Mutations in ADAR1, IFIH1, and RNASEH2B Presenting As Spastic Paraplegia

Neuropediatrics, 2014
Hereditary spastic paraplegia is a neurodegenerative phenotype characterized by a progressive loss of corticospinal motor tract function. In a majority of affected individuals the pathogenesis remains undetermined.We identified a series of patients with a phenotype of nonsyndromic spastic paraplegia in whom no diagnosis had been reached before exome ...
Crow, Y, Zaki, M, Abdel-Hamid, M, Abdel-Salam, G, Boespflug-Tanguy, O, Cordeiro, N, Gleeson, J, Gowrinathan, N, Laugel, Vincent, Renaldo, F, Rodriguez, D, Livingston, J, Rice, G   +12 more
openaire   +3 more sources

ADAR1 expression is associated with tumour-infiltrating lymphocytes in triple-negative breast cancer

Tumor Biology, 2017
Tumours with a high mutation burden exhibit considerable neoantigens and tumour-infiltrating lymphocytes. RNA editing by ADAR1 is a source of changes in epitope.
In Hye Song, Young-Ae Kim, Sun-Hee Heo, In Ah Park, Miseon Lee, Won Seon Bang, Hye Seon Park, Gyungyub Gong, Hee Jin Lee   +8 more
doaj   +1 more source

ADAR1 is increased in prostate cancer progression and silencing reduces A-to-I editing and cell growth while enhancing apoptosis and adhesion

Scientific Reports
Adenosine deaminase acting on RNA 1 (ADAR1) catalyses adenosine-to-inosine (A-to-I) RNA editing and has emerged as a regulator of cell biology. Here, we investigate the expression and function of ADAR1 in prostate cancer using in vitro models and ...
Stefania Kalogera, Klaudia Detkiewicz, Lisbeth Verk, Irem Cemile Eroglu, Youssef Khaled Abdelhamid, Gjendine Voss, Margareta Persson, Martin Sjöström, Anders Bjartell, Yvonne Ceder   +9 more
doaj   +1 more source

Effect of interferons on expression of adenosine deaminase acting on RNA 1 and hepatitis B virus replication in human hepatocellular carcinoma cells in vitro

Di-san junyi daxue xuebao, 2019
Objective To investigate the effect of type Ⅰ interferons (IFN-α and IFN-β) and type Ⅱ interferon (IFN-γ) on the expression of adenosine deaminase acting on RNA 1 (ADAR1, P110 and P150) and hepatitis B virus (HBV) replication in hepatocellular carcinoma (
LI Yimin, LI Yimin, YUAN Lin, YUAN Lin, YANG Shengyong   +4 more
doaj   +1 more source

The majority of A-to-I RNA editing is not required for mammalian homeostasis

Genome Biology, 2019
Background Adenosine-to-inosine (A-to-I) RNA editing, mediated by ADAR1 and ADAR2, occurs at tens of thousands to millions of sites across mammalian transcriptomes.
Alistair M. Chalk, Scott Taylor, Jacki E. Heraud-Farlow, Carl R. Walkley   +3 more
doaj   +1 more source

Malignant A-to-I RNA editing by ADAR1 drives T cell acute lymphoblastic leukemia relapse via attenuating dsRNA sensing

Cell Reports
Summary: Leukemia-initiating cells (LICs) are regarded as the origin of leukemia relapse and therapeutic resistance. Identifying direct stemness determinants that fuel LIC self-renewal is critical for developing targeted approaches.
Maria Rivera, Haoran Zhang, Jessica Pham, Jane Isquith, Qingchen Jenny Zhou, Larisa Balaian, Roman Sasik, Sabina Enlund, Adam Mark, Wenxue Ma, Frida Holm, Kathleen M. Fisch, Dennis John Kuo, Catriona Jamieson, Qingfei Jiang   +14 more
doaj   +1 more source

ADAR1 Regulates the ERK/c-FOS/MMP-9 Pathway to Drive the Proliferation and 
Migration of Non-small Cell Lung Cancer Cells

Chinese Journal of Lung Cancer
Background and objective Double-stranded RNA-specific adenosine deaminase 1 (ADAR1) binds to double-stranded RNA and catalyzes the deamination of adenosine (A) to inosine (I).
Li ZHANG, Xue PAN, Wenqing YAN, Shuilian ZHANG, Chiyu MA, Chenpeng LI, Kexin ZHU, Nijia LI, Zizhong YOU, Xueying ZHONG, Zhi XIE, Zhiyi LV, Weibang GUO, Yu CHEN, Danxia LU, Xuchao ZHANG   +15 more
doaj   +1 more source

ADAR1: a mast regulator of aging and immunity

Signal Transduction and Targeted Therapy, 2023
Yigan Zhang, Jinyue Zhang, Yuanchao Xue
openaire   +3 more sources

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source