Results 61 to 70 of about 4,773 (159)

Malignant A-to-I RNA editing by ADAR1 drives T cell acute lymphoblastic leukemia relapse via attenuating dsRNA sensing

Cell Reports
Summary: Leukemia-initiating cells (LICs) are regarded as the origin of leukemia relapse and therapeutic resistance. Identifying direct stemness determinants that fuel LIC self-renewal is critical for developing targeted approaches.
Maria Rivera, Haoran Zhang, Jessica Pham, Jane Isquith, Qingchen Jenny Zhou, Larisa Balaian, Roman Sasik, Sabina Enlund, Adam Mark, Wenxue Ma, Frida Holm, Kathleen M. Fisch, Dennis John Kuo, Catriona Jamieson, Qingfei Jiang   +14 more
doaj   +1 more source

ADAR1 Function Regulates Innate Immune Activation and Susceptibility to Viral Infections

Proceedings, 2020
Viral infection induces innate intracellular antiviral defenses, aimed at restricting virus replication and spread. Therefore, understanding the role and function of innate immune modulators can help to establish novel strategies for viral control. Here,
Maria Pujantell, Eva Riveira-Muñoz, Edurne García-Vidal, Lucía Gutiérrez-Chamorro, Roger Badia, Bonaventura Clotet, Ester Ballana   +6 more
doaj   +1 more source

ADAR1 Regulates the ERK/c-FOS/MMP-9 Pathway to Drive the Proliferation and 
Migration of Non-small Cell Lung Cancer Cells

Chinese Journal of Lung Cancer
Background and objective Double-stranded RNA-specific adenosine deaminase 1 (ADAR1) binds to double-stranded RNA and catalyzes the deamination of adenosine (A) to inosine (I).
Li ZHANG, Xue PAN, Wenqing YAN, Shuilian ZHANG, Chiyu MA, Chenpeng LI, Kexin ZHU, Nijia LI, Zizhong YOU, Xueying ZHONG, Zhi XIE, Zhiyi LV, Weibang GUO, Yu CHEN, Danxia LU, Xuchao ZHANG   +15 more
doaj   +1 more source

Overexpression of Egr1 Transcription Regulator Contributes to Schwann Cell Differentiation Defects in Neural Crest-Specific Adar1 Knockout Mice

Cells
Adenosine deaminase acting on RNA 1 (ADAR1) is the principal enzyme for the adenosine-to-inosine RNA editing that prevents the aberrant activation of cytosolic nucleic acid sensors by endogenous double stranded RNAs and the activation of interferon ...
Lisa Zerad, Nadjet Gacem, Fanny Gayda, Lucie Day, Ketty Sinigaglia, Laurence Richard, Melanie Parisot, Nicolas Cagnard, Stephane Mathis, Christine Bole-Feysot, Mary A. O’Connell, Veronique Pingault, Emilie Dambroise, Liam P. Keegan, Jean Michel Vallat, Nadege Bondurand   +15 more
doaj   +1 more source

Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line

eLife, 2017
ADAR1 isoforms are adenosine deaminases that edit and destabilize double-stranded RNA reducing its immunostimulatory activities. Mutation of ADAR1 leads to a severe neurodevelopmental and inflammatory disease of children, Aicardi-Goutiéres syndrome.
Yize Li, Shuvojit Banerjee, Stephen A Goldstein, Beihua Dong, Christina Gaughan, Sneha Rath, Jesse Donovan, Alexei Korennykh, Robert H Silverman, Susan R Weiss   +9 more
doaj   +1 more source

ADAR1 as a prognostic marker for patients with colorectal cancer and synchronous liver metastasis and a predictor of chemotherapy efficacy

Scientific Reports
RNA editing by adenosine deaminase acting on RNA (ADAR) enzymes plays a role in cancer progression. However, its clinical significance in metastatic colorectal cancer (CRC) remains unclear.
Kaori Nitta, Kunitoshi Shigeyasu, Yoshitaka Kondo, Hibiki Umeda, Toshiaki Takahashi, Kazuya Moriwake, Kazuhiro Yoshida, Sho Takeda, Yuki Matsumi, Hiroyuki Kishimoto, Tomokazu Fuji, Kazuya Yasui, Kosei Takagi, Masashi Kayano, Shunsuke Nakamura, Hiroyuki Michiue, Hideki Yamamoto, Nobuhiko Kanaya, Yuhei Kondo, Eiki Miyake, Yusuke Yoshida, Ryohei Shoji, Yoshihiko Kakiuchi, Hiroshi Tazawa, Shunsuke Kagawa, Toshiyoshi Fujiwara   +25 more
doaj   +1 more source

8-Chloroadenosine suppresses hepatocellular carcinoma progression via ADAR1/PPARγ axis-mediated lipid metabolism

Genes and Diseases
The invasive and metastatic potential of hepatocellular carcinoma (HCC) is tightly linked to lipid metabolic reprogramming. However, existing knowledge of the molecular regulatory network governing lipid metabolism in HCC remains incomplete.
Jing Liu, Yongle Zhao, Xue Gong, Lin Yuan, Shengyong Yang, Wenwen Jian, Han Yan, Honglin Chen, Zhicheng Yang, Yiheng Sun, Tianle Gu, He Lu, Hongyun Zhao, Zeng Tu   +13 more
doaj   +1 more source

ADAR1: a mast regulator of aging and immunity

Signal Transduction and Targeted Therapy, 2023
Yigan Zhang, Jinyue Zhang, Yuanchao Xue
openaire   +3 more sources

ADAR1 may be involved in the proliferation of acute myeloid leukemia cells via regulation of the Wnt pathway

Cancer Management and Research, 2019
Han Xiao, Qian Cheng, Xinyu Wu, Yishu Tang, Jing Liu, Xin Li Department of Hematology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of ChinaCorrespondence: Xin Li; Jing LiuDepartment of Hematology, The ...
Xiao H, Cheng Q, Wu X, Tang Y, Liu J, Li X   +5 more
doaj  

An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation

Cell Reports
Summary: Adar null mutant mouse embryos die with aberrant double-stranded RNA (dsRNA)-driven interferon induction, and Adar Mavs double mutants, in which interferon induction is prevented, die soon after birth.
Ketty Sinigaglia, Anna Cherian, Qiupei Du, Valentina Lacovich, Dragana Vukić, Janka Melicherová, Pavla Linhartova, Lisa Zerad, Stanislav Stejskal, Radek Malik, Jan Prochazka, Nadège Bondurand, Radislav Sedláček, Mary A. O’Connell, Liam P. Keegan   +14 more
doaj   +1 more source