Results 41 to 50 of about 4,773 (159)

Cardiomyocyte Specific Deletion of ADAR1 Causes Severe Cardiac Dysfunction and Increased Lethality

Frontiers in Cardiovascular Medicine, 2020
Background: Adenosine deaminase acting on RNA 1 (ADAR1) is a double-stranded RNA-editing enzyme that is involved in several functions including the deamination of adenosine to inosine, RNA interference (RNAi) mechanisms and microRNA (miRNA) processing ...
Hamid el Azzouzi, Hamid el Azzouzi, Andreia P. Vilaça, Dries A. M. Feyen, Willemijn M. Gommans, Roel A. de Weger, Pieter A. F. Doevendans, Pieter A. F. Doevendans, Pieter A. F. Doevendans, Joost P. G. Sluijter, Joost P. G. Sluijter, Joost P. G. Sluijter   +11 more
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Loss of ADAR1 in macrophages in combination with interferon gamma suppresses tumor growth by remodeling the tumor microenvironment

Journal for ImmunoTherapy of Cancer, 2023
Background ADAR1, the major enzyme for RNA editing, has emerged as a tumor-intrinsic key determinant for cancer immunotherapy efficacy through modulating interferon-mediated innate immunity.
Jie Wu, Hang Zhou, Han Liang, Weiwei Lin, Xiaoyan Xu, Yikai Luo, Haowan Zhang, Ge Jin, Chahua Guo   +8 more
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A new function for the RNA-editing enzyme ADAR1 [PDF]

Nature Immunology, 2009
ADAR1 catalyzes the deamination of adenosine to inosine in double-stranded RNA. This RNA-editing enzyme is now shown to be involved in hematopoiesis, where it acts to suppress interferon signaling and to block premature apoptosis.
Hisashi, Iizasa, Kazuko, Nishikura
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ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling [PDF]

Nature Immunology, 2008
The deaminase ADAR1 edits adenosines in nuclear transcripts of nervous tissue and is required in the fetal liver of the developing mouse embryo. Here we show by inducible gene disruption in mice that ADAR1 is essential for maintenance of both fetal and adult hematopoietic stem cells.
Hartner, JC, Walkley, CR, Lu, J, Orkin, SH   +3 more
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Loss of Adenosine Deaminase Acting on RNA 1 Induces Panoptosis and Immune Response in Ulcerative Colitis Gut Mucosa

MedComm
The gut virome is a complex community that exists in equilibrium with the host. Disruptions of this balance could drive the development of inflammatory diseases, such as inflammatory bowel disease (IBD). RNA editing, particularly A‐to‐I editing by ADAR1,
Andrea Iannucci, Marco Colella, Macarena Quiroga, Rachele Frascatani, Lorenzo Tomassini, Claudia Maresca, Eleonora Franzè, Federica Laudisi, Giuseppe Sica, Irene Marafini, Alessandro Michienzi, Ivan Zanoni, Giovanni Monteleone, Ivan Monteleone   +13 more
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ADAR1: Beyond Just an RNA Editor

Annual Review of Cell and Developmental Biology
The RNA editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) has recently emerged from relative obscurity to be recognized as a key player in a variety of inflammatory diseases, including cancer. This growing recognition has generated interest in developing ADAR1 inhibitors; however, several fundamental questions about the ...
Martin, Marônek, Valentina, Lacovich, Anna, Cherian, Damiano, Amoruso, Pavla, Linhartova, Qiupei, Du, Janka, Melicherová, Liam P, Keegan, Mary A, O'Connell   +8 more
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The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

Cell Reports, 2014
The ADAR RNA-editing enzymes deaminate adenosine bases to inosines in cellular RNAs. Aberrant interferon expression occurs in patients in whom ADAR1 mutations cause Aicardi-Goutières syndrome (AGS) or dystonia arising from striatal neurodegeneration ...
Niamh M. Mannion, Sam M. Greenwood, Robert Young, Sarah Cox, James Brindle, David Read, Christoffer Nellåker, Cornelia Vesely, Chris P. Ponting, Paul J. McLaughlin, Michael F. Jantsch, Julia Dorin, Ian R. Adams, A.D.J. Scadden, Marie Öhman, Liam P. Keegan, Mary A. O’Connell   +16 more
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A novel aptamer-antibody sandwich electrochemical sensor for detecting ADAR1 in complex biological samples

Biosensors and Bioelectronics: X
Human adenosine deaminase acting on RNA1 (ADAR1) is an adenosine-to-inosine (A-to-I) RNA-editing enzyme involved in various types of cancer progression. ADAR1 has emerged as a novel prognostic biomarker for cancer. This study describes the application of
Madhu Biyani, Kirti Sharma, Maeda Shoei, Hinako Akashi, Masataka Nakano, Miki Nakajima, Manish Biyani   +6 more
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SUMO-1 Modification Alters ADAR1 Editing Activity [PDF]

Molecular Biology of the Cell, 2005
We identify ADAR1, an RNA-editing enzyme with transient nucleolar localization, as a novel substrate for sumoylation. We show that ADAR1 colocalizes with SUMO-1 in a subnucleolar region that is distinct from the fibrillar center, the dense fibrillar component, and the granular component.
Desterro, Joana, Keegan, Liam P., Jaffray, Ellis, Hay, Ron T., O'Connell, Mary A., Carmo-Fonseca, Maria   +5 more
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ADAR1 silencing-induced HUVEC apoptosis is mediated by FGFR2 under hypoxia stress

Drug Design, Development and Therapy, 2018
Yun Jiang,1 Zhancheng Wang,1 Xu Chen,1 Wei Wang,1 Xiaowei Wang2 1Department of Cardiology, The Eighth People’s Hospital of Shanghai, Shanghai 200233, China; 2Shanghai Weiang Info Tech Ltd., Shanghai 200233, China Background: The adenosine ...
Jiang Y, Wang Z, Chen X, Wang W, Wang X
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