Results 41 to 50 of about 4,973 (174)

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

An essential role of adenosine deaminase acting on RNA 1 in coeliac disease mucosa

Frontiers in Immunology, 2023
Background and aimType I interferons (IFNs) are highly expressed in the gut mucosa of celiac disease (CD) gut mucosa and stimulates immune response prompted by gluten ingestion, but the processes that maintain the production of these inflammatory ...
Davide Di Fusco, Maria Teresa Segreto, Andrea Iannucci, Claudia Maresca, Eleonora Franzè, Giulia Di Maggio, Antonio Di Grazia, Siro Boccanera, Federica Laudisi, Irene Marafini, Omero Alessandro Paoluzi, Alessandro Michienzi, Giovanni Monteleone, Giovanni Monteleone, Ivan Monteleone   +14 more
doaj   +1 more source

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

Loss of Adenosine Deaminase Acting on RNA 1 Induces Panoptosis and Immune Response in Ulcerative Colitis Gut Mucosa

MedComm
The gut virome is a complex community that exists in equilibrium with the host. Disruptions of this balance could drive the development of inflammatory diseases, such as inflammatory bowel disease (IBD). RNA editing, particularly A‐to‐I editing by ADAR1,
Andrea Iannucci, Marco Colella, Macarena Quiroga, Rachele Frascatani, Lorenzo Tomassini, Claudia Maresca, Eleonora Franzè, Federica Laudisi, Giuseppe Sica, Irene Marafini, Alessandro Michienzi, Ivan Zanoni, Giovanni Monteleone, Ivan Monteleone   +13 more
doaj   +1 more source

The DNA/RNA Helicase SETX Maintains R‐Loop Homeostasis to Promote Chemoresistance in Ovarian Cancer

Cancer Science, EarlyView.
SETX maintains R‐loop homeostasis by resolving excessive R‐loops, thereby promoting tumor initiation and chemoresistance. Deficiency of SETX leads to accumulation of unsolved pathological R‐loops, resulting in irreparable DNA damage and ultimately leading to tumor suppression and chemosensitivity.
Zi‐Wei Hu, Tu‐Nan Xu, Zi‐Ying Wang, Xin Zheng, Duan‐Yong Feng, Xiao‐Min Wang, Er‐Suo Jin, Ming Ren, Xiao‐Min Yang, Xian‐Chao Zhang, Xuan Che, Wei‐Wei Pan, Zha‐Jun Zhan, Shu‐Qun Cheng   +13 more
wiley   +1 more source

Cardiomyocyte Specific Deletion of ADAR1 Causes Severe Cardiac Dysfunction and Increased Lethality

Frontiers in Cardiovascular Medicine, 2020
Background: Adenosine deaminase acting on RNA 1 (ADAR1) is a double-stranded RNA-editing enzyme that is involved in several functions including the deamination of adenosine to inosine, RNA interference (RNAi) mechanisms and microRNA (miRNA) processing ...
Hamid el Azzouzi, Hamid el Azzouzi, Andreia P. Vilaça, Dries A. M. Feyen, Willemijn M. Gommans, Roel A. de Weger, Pieter A. F. Doevendans, Pieter A. F. Doevendans, Pieter A. F. Doevendans, Joost P. G. Sluijter, Joost P. G. Sluijter, Joost P. G. Sluijter   +11 more
doaj   +1 more source

ADAR1: Beyond Just an RNA Editor

Annual Review of Cell and Developmental Biology
The RNA editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) has recently emerged from relative obscurity to be recognized as a key player in a variety of inflammatory diseases, including cancer. This growing recognition has generated interest in developing ADAR1 inhibitors; however, several fundamental questions about the ...
Martin, Marônek, Valentina, Lacovich, Anna, Cherian, Damiano, Amoruso, Pavla, Linhartova, Qiupei, Du, Janka, Melicherová, Liam P, Keegan, Mary A, O'Connell   +8 more
openaire   +2 more sources

SUMO-1 Modification Alters ADAR1 Editing Activity [PDF]

Molecular Biology of the Cell, 2005
We identify ADAR1, an RNA-editing enzyme with transient nucleolar localization, as a novel substrate for sumoylation. We show that ADAR1 colocalizes with SUMO-1 in a subnucleolar region that is distinct from the fibrillar center, the dense fibrillar component, and the granular component.
Desterro, Joana, Keegan, Liam P., Jaffray, Ellis, Hay, Ron T., O'Connell, Mary A., Carmo-Fonseca, Maria   +5 more
openaire   +3 more sources

Loss of ADAR1 in macrophages in combination with interferon gamma suppresses tumor growth by remodeling the tumor microenvironment

Journal for ImmunoTherapy of Cancer, 2023
Background ADAR1, the major enzyme for RNA editing, has emerged as a tumor-intrinsic key determinant for cancer immunotherapy efficacy through modulating interferon-mediated innate immunity.
Jie Wu, Hang Zhou, Han Liang, Weiwei Lin, Xiaoyan Xu, Yikai Luo, Haowan Zhang, Ge Jin, Chahua Guo   +8 more
doaj   +1 more source

Inborn errors of immunity in children with neuroinflammation

Developmental Medicine &Child Neurology, EarlyView.
Abstract Inborn errors of immunity (IEIs), an expanding group of monogenic disorders with diverse clinical manifestations, are increasingly recognized to include neuroinflammatory disease. Examples of diseases included under this umbrella are Aicardi–Goutières syndrome, deficiency of adenosine deaminase 2, familial haemophagocytic lymphohistiocytosis ...
Eppie M Yiu, Dilan Dissanayake, Jessie Cunningham, Helen Branson, Ori Scott, E Ann Yeh   +5 more
wiley   +1 more source