Results 41 to 50 of about 8,092 (217)

ADAR1 isoform involvement in embryonic lethality [PDF]

Proceedings of the National Academy of Sciences, 2011
Letters to the editor recently published in PNAS (1, 2) challenged and defended a claim made on a recent article (3). Matthaei et al. (1) questioned whether the animal model used by Ward et al. (3) was adequate to support their claim that the P150 isoform of the RNA editing enzyme adenosine deaminase 1 (ADAR1) is required for embryogenesis.
Richard A. Steinman, Qingde Wang
openaire   +1 more source

RNA editing signature during myeloid leukemia cell differentiation [PDF]

, 2017
Adenosine deaminases acting on RNA (ADARs) are key proteins for hematopoietic stem cell self-renewal and for survival of differentiating progenitor cells. However, their specific role in myeloid cell maturation has been poorly investigated.
A Athanasiadis, A Gallo, AS Shifera, BE Wulff, BJ Liddicoat, BL Bass, C Cenci, C Sundstrom, C Trapnell, C Trapnell, D Laxminarayana, E Picardi, E Picardi, G Camilli, H Aberle, H Li, JB Patterson, JC Hartner, JH Bahn, JM Desterro, Justin M. Thomas, K Nishikura, L Bazak, L Chen, M D'Antonio, M Daigneault, M Higuchi, M Vogler, MA Zipeto, MA Zipeto, N Mannion, N Paz-Yaacov, Q Jiang, Q Wang, Q Wang, R Marcucci, R XuFeng, RA Steinman, RJ Orlowski, S Tomaselli, S Tomaselli, T Hwang, TD Wu, TR Dawson, W Slotkin, Y Li, Y Pinto, YJ Crow, YS Baek   +48 more
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Roles of miR-432 and circ_0000418 in mediating the anti-depressant action of ADAR1

Neurobiology of Stress, 2021
Adenosine deaminase acting on RNA1 (ADAR1) is a newly discovered epigenetic molecule marker that is sensitive to environmental stressors. A recent study has demonstrated that ADAR1 affects BDNF expression via miR-432 and is involved in antidepressant ...
Xiaonan Zhang, Wei Yan, Ying Xue, Hong Xu, Jinying Li, Ziwei Zhao, Ye Sun, Yanfang Wang, Jiaqian He, Yuyue Huang, Deqin Yu, Zhaoyang Xiao, Shengming Yin   +12 more
doaj   +1 more source

The Nefarious Nexus of Noncoding RNAs in Cancer [PDF]

, 2018
The past decade has witnessed enormous progress, which has seen the noncoding RNAs (ncRNAs) turn from the so called dark matter RNA to critical functional molecules, influencing most physiological processes in development and disease contexts.
Anastasiadou, Eleni, Faggioni, Alberto, J Slack, Frank, Trivedi, Pankaj   +3 more
core   +1 more source

Activity-regulated RNA editing in select neuronal subfields in hippocampus [PDF]

, 2012
RNA editing by adensosine deaminases is a widespread mechanism to alter genetic information in metazoa. In addition to modifications in non-coding regions, editing contributes to diversification of protein function, in analogy to alternative splicing ...
Ales Balik, Altschul, Andrew C. Penn, Aruscavage, Bass, Birney, Bratt, Brorson, Coleman, Coleman, Daniel, Darty, Dawson, de la Mata, Feldmeyer, Feng, Fisahn, Gahwiler, Gainey, Gallo, Ge, Goodman, Greger, Greger, Greger, Gurevich, Hamada, Hideyama, Hideyama, Higuchi, Higuchi, Hoopengardner, Hundley, Ingo H. Greger, Jepson, Katoh, Kent, Lee, Lein, Li, Liu, Lomeli, Maas, Marcucci, Palladino, Paul, Peng, Peng, Penn, Penn, Penn, Pozo, Rosenthal, Rueter, Ryman, Sanjana, Schoft, Seeburg, Seeburg, Sommer, Sommer, Stefl, Stefl, Tariq, Toth, Traynelis, Turrigiano, Turrigiano, Valente, Venkatesh, Wang, Witter, Xie, Zsofia Nemoda   +73 more
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Loss of ADAR1 in macrophages in combination with interferon gamma suppresses tumor growth by remodeling the tumor microenvironment

Journal for ImmunoTherapy of Cancer, 2023
Background ADAR1, the major enzyme for RNA editing, has emerged as a tumor-intrinsic key determinant for cancer immunotherapy efficacy through modulating interferon-mediated innate immunity.
Jie Wu, Hang Zhou, Han Liang, Weiwei Lin, Xiaoyan Xu, Yikai Luo, Haowan Zhang, Ge Jin, Chahua Guo   +8 more
doaj   +1 more source

p150 ADAR1 isoform involved in maintenance of HeLa cell proliferation [PDF]

, 2006
Background RNA-specific adenosine deaminase ADAR1 is ubiquitously expressed in a variety of mammalian cells and tissues. Although its physiological importance in non-nervous tissues has been confirmed by analysis of null mutation phenotypes, few ...
Haifang Wang, Zheng Hou, Yumei Wu, Xue Ma, Xiaoxing Luo, U Kim, MA O'Connell, Y Liu, PH Seeburg, CE Samuel, CX George, CX George, SK Wong, S Sato, JC Hartner, Q Wang, Q Wang, CX George, MS Paul, RW Wagner, S Maas, JH Yang, JM Desterro, W James, W Zhao, R Giavazzi, Y Nie, Y Nie, CR Eckmann, SK Wong, SW Knight, JH Yang, DD Kim, MR Vila, EY Levanon, A Athanasiadis, M Blow   +36 more
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An essential role of adenosine deaminase acting on RNA 1 in coeliac disease mucosa

Frontiers in Immunology, 2023
Background and aimType I interferons (IFNs) are highly expressed in the gut mucosa of celiac disease (CD) gut mucosa and stimulates immune response prompted by gluten ingestion, but the processes that maintain the production of these inflammatory ...
Davide Di Fusco, Maria Teresa Segreto, Andrea Iannucci, Claudia Maresca, Eleonora Franzè, Giulia Di Maggio, Antonio Di Grazia, Siro Boccanera, Federica Laudisi, Irene Marafini, Omero Alessandro Paoluzi, Alessandro Michienzi, Giovanni Monteleone, Giovanni Monteleone, Ivan Monteleone   +14 more
doaj   +1 more source

ADAR1: A New Target for Immuno-oncology Therapy [PDF]

Molecular Cell, 2019
Three recent studies by Ishizuka et al. (2019), Liu et al. (2019), and Gannon et al. (2018) show that deleting RNA editing enzyme ADAR1 could induce higher cell lethality and render tumor cells more vulnerable to immunotherapy, pinpointing ADAR1 as a new immuno-oncology target.
Amruta, Bhate, Tao, Sun, Jin Billy, Li
openaire   +2 more sources

Crystal structure of a poxvirus-like zalpha domain from cyprinid herpesvirus 3 [PDF]

, 2013
Zalpha domains are a subfamily of the winged helix-turn-helix domains sharing the unique ability to recognize CpG repeats in the left-handed Z-DNA conformation.
Athanasiadis, Alekos, Correia, Silvia, de Rosa, Matteo, Figueiredo, Delio, Kuś, Krzysztof, Parkhouse, R Michael E, Paulo, Lara Martins, Tomé, Ana Rita, Zacarias, Sónia   +8 more
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