Results 21 to 30 of about 4,973 (174)

ADAR1 restricts LINE-1 retrotransposition [PDF]

Nucleic Acids Research, 2016
Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosines to inosines in double-stranded RNAs. ADAR1 was demonstrated to be functional on different viruses exerting either antiviral or proviral effects. Concerning HIV-1, several studies showed that ADAR1 favors viral replication.
Orecchini, Elisa, Doria, Margherita, Antonioni, Ambra, Galardi, Silvia, Ciafré, Silvia Anna, Frassinelli, Loredana, MANCONE, Carmine, Montaldo, Claudia, TRIPODI, Marco, Michienzi, Alessandro   +9 more
openaire   +3 more sources

Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis

Genome Biology, 2017
Background Adenosine-to-inosine (A-to-I) editing of dsRNA by ADAR proteins is a pervasive epitranscriptome feature. Tens of thousands of A-to-I editing events are defined in the mouse, yet the functional impact of most is unknown. Editing causing protein
Jacki E. Heraud-Farlow, Alistair M. Chalk, Sandra E. Linder, Qin Li, Scott Taylor, Joshua M. White, Lokman Pang, Brian J. Liddicoat, Ankita Gupte, Jin Billy Li, Carl R. Walkley   +10 more
doaj   +1 more source

ADAR1 has an oncogenic function and can be a prognostic factor in cervical cancer

Scientific Reports, 2023
Adenosine deaminase acting on RNA 1 (ADAR1), a recently described epigenetic modifier, is believed to play a critical oncogenic role in human cancers. However, its functional role and clinical significance in cervical cancer (CC) remain unclear.
Keiichiro Nakamura, Kunitoshi Shigeyasu, Kazuhiro Okamoto, Hirofumi Matsuoka, Hisashi Masuyama   +4 more
doaj   +1 more source

ADAR1 promotes systemic sclerosis via modulating classic macrophage activation

Frontiers in Immunology, 2022
IntroductionAs a multisystem autoimmune disorder disease, systemic sclerosis (SSc) is characterized by inflammation and fibrosis in the skin and other internal organs.
Chenming Sun, Chenming Sun, Chenming Sun, Dunpeng Cai, Shi-You Chen, Shi-You Chen   +5 more
doaj   +1 more source

ADAR1: “Editor-in-Chief” of Cytoplasmic Innate Immunity [PDF]

Frontiers in Immunology, 2019
Specialized receptors that recognize molecular patterns such as double stranded RNA duplexes-indicative of viral replication-are potent triggers of the innate immune system. Although their activation is beneficial during viral infection, RNA transcribed from endogenous mobile genetic elements may also act as ligands potentially causing autoimmunity ...
Lamers, Mart, van den Hoogen, BG, Haagmans, Bart   +2 more
openaire   +3 more sources

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation

Cell Reports, 2021
Summary: Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1 (ADAR1) causes the severe autoinflammatory disease Aicardi-Goutières syndrome (AGS). ADAR1 converts adenosines into inosines within dsRNA. This process called A-to-I
Richard de Reuver, Evelien Dierick, Bartosz Wiernicki, Katrien Staes, Leen Seys, Ellen De Meester, Tuur Muyldermans, Alexander Botzki, Bart N. Lambrecht, Filip Van Nieuwerburgh, Peter Vandenabeele, Jonathan Maelfait   +11 more
doaj   +1 more source

ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation

Journal of Experimental & Clinical Cancer Research, 2019
Background Adenosine deaminases acting on RNA (ADARs) are involved in adenosine-to-inosine (A-to-I) editing and implicated in tumorigenesis and prognosis.
Xue Liu, Yu Fu, Jiadong Huang, Meng Wu, Zhenxing Zhang, Rongyao Xu, Ping Zhang, Shouwei Zhao, Laikui Liu, Hongbing Jiang   +9 more
doaj   +1 more source

ADAR1 Is Involved in the Development of Microvascular Lung Injury [PDF]

Circulation Research, 2001
Abstract —Deamination of adenosine on pre-mRNA to inosine is a recently discovered process of posttranscription modification of pre-mRNA, termed A-to-I RNA editing, which results in the production of proteins not inherent in the genome.
R, Rabinovici, K, Kabir, M, Chen, Y, Su, D, Zhang, X, Luo, J H, Yang   +6 more
openaire   +2 more sources

RNA editing by ADAR1 marks dsRNA as “self” [PDF]

Cell Research, 2015
A paper recently published in Science reports that adenosine deaminase acting on RNA 1-dependent adenosine-to-inosine editing marks endogenous double strand RNA as self and prevents their immune recognition by cytosolic RNA sensor MDA5.
Zhou, Yu, Taoyong, Chen, Xuetao, Cao
openaire   +2 more sources

ADAR1 Facilitates KSHV Lytic Reactivation by Modulating the RLR-Dependent Signaling Pathway

Cell Reports, 2020
Summary: Kaposi’s sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA virus that exhibits two alternative life cycles: latency and lytic reactivation.
Huirong Zhang, Guoxin Ni, Blossom Damania   +2 more
doaj   +1 more source