Results 11 to 20 of about 4,973 (174)

ADAR1 Alleviates Inflammation in a Murine Sepsis Model via the ADAR1-miR-30a-SOCS3 Axis

Mediators of Inflammation, 2020
Adenosine deaminase acting on double-stranded RNA 1 (ADAR1) mediates adenosine-to-inosine (A-to-I) RNA editing events. ADAR1 is highly expressed in “septic” macrophages and in small intestinal tissues of mice with sepsis.
Zhou Shangxun, Li Junjie, Zhao Wei, Wang Yutong, Jia Wenyuan, Liu Shanshou, Wang Yanjun, Wang Qianmei, Feng Zhusheng, Yu Chaoping, Zhuang Ran, Yin Wen, Huang Yang   +12 more
doaj   +3 more sources

Role of ADAR1 on Proliferation and Differentiation in Porcine Preadipocytes

Animals
Recent research has identified ADAR1 as a participant in the regulation of lipid accumulation in mice. However, there are no reports on the roles of ADAR1 in proliferation, apoptosis and differentiation of porcine preadipocytes.
Menghuan Yang, Jun Jiang, Ruimin Ren, Ning Gao, Jun He, Yuebo Zhang   +5 more
doaj   +3 more sources

ADAR1-Mediated RNA Editing and Its Role in Cancer

Frontiers in Cell and Developmental Biology, 2022
It is well known that the stability of RNA, the interaction between RNA and protein, and the correct translation of protein are significant forces that drive the transition from normal cell to malignant tumor.
Jizhe Liu, Jizhe Liu, Jizhe Liu, Fei Wang, Fei Wang, Yindan Zhang, Yindan Zhang, Yindan Zhang, Jingfeng Liu, Bixing Zhao, Bixing Zhao   +10 more
doaj   +3 more sources

The ADAR1 editome reveals drivers of editing-specificity for ADAR1-isoforms [PDF]

, 2021
Abstract Adenosine deaminase acting on RNA (ADAR) (also known as ADAR1) promotes A-to-I conversion in double-stranded and highly structured RNAs. ADAR1 has two isoforms transcribed from different promoters: ADAR1p150, which is mainly cytoplasmic and interferon-inducible, and constitutively expressed ADAR1p110 that is primarily localized
Renata Kleinova, Alina F. Leuchtenberger, Claudio Lo Giudice, Andrea Tanzer, Sophia Derdak, Ernesto Picardi, Michael F. Jantsch   +6 more
openaire   +1 more source

The ADAR1 editome reveals drivers of editing-specificity for ADAR1-isoforms

Nucleic Acids Research, 2023
Abstract Adenosine deaminase acting on RNA ADAR1 promotes A-to-I conversion in double-stranded and structured RNAs. ADAR1 has two isoforms transcribed from different promoters: cytoplasmic ADAR1p150 is interferon-inducible while ADAR1p110 is constitutively expressed and primarily localized in the nucleus.
Kleinova, Renata, Rajendra, Vinod, Leuchtenberger, Alina F, Lo Giudice, Claudio, Vesely, Cornelia, Kapoor, Utkarsh, Tanzer, Andrea, Derdak, Sophia, Picardi, Ernesto, Jantsch, Michael F   +9 more
openaire   +4 more sources

Substrate recognition by ADAR1 and ADAR2 [PDF]

RNA, 2001
RNA editing catalyzed by ADAR1 and ADAR2 involves the site-specific conversion of adenosine to inosine within imperfectly duplexed RNA. ADAR1- and ADAR2-mediated editing occurs within transcripts of glutamate receptors (GluR) in the brain and in hepatitis delta virus (HDV) RNA in the liver.
S K, Wong, S, Sato, D W, Lazinski
openaire   +2 more sources

Early brain-penetrant immunotherapy reverses interferon signature and improves motor outcome in a case of ADAR1-related Aicardi-Goutières syndrome. [PDF]

Clin Transl Immunology
Abstract Objectives Aicardi‐Goutières syndrome (AGS) is a genetic interferonopathy resulting from defects in nucleic acid metabolism and subsequent enhanced type I interferon signalling. We report how an expedited genomic diagnosis in conjunction with natural history data can enable a long‐term brain‐penetrant anti‐inflammatory regimen to optimise ...
Dale RC, Hayes J, Han VX, Dissanayake R, Lau X, Farrar M, Gloss B, Hofer M, Tantsis E, Lorentzos M, Abbas S, Crow YJ, Mohammad S, Patel S.   +13 more
europepmc   +2 more sources

ADAR1 and MicroRNA; A Hidden Crosstalk in Cancer [PDF]

International Journal of Molecular Sciences, 2017
The evolution of cancer cells is believed to be dependent on genetic or epigenetic alterations. However, this concept has recently been challenged by another mode of nucleotide alteration, RNA editing, which is frequently up-regulated in cancer. RNA editing is a biochemical process in which either Adenosine or Cytosine is deaminated by a group of RNA ...
Charles Cho, Seung-Jae Myung, Suhwan Chang   +2 more
openaire   +2 more sources

ADAR1-mediated regulation of melanoma invasion [PDF]

Nature Communications, 2018
AbstractMelanoma cells use different migratory strategies to exit the primary tumor mass and invade surrounding and subsequently distant tissues. We reported previously that ADAR1 expression is downregulated in metastatic melanoma, thereby facilitating proliferation.
Yael Nemlich, Erez Nissim Baruch, Michal Judith Besser, Einav Shoshan, Menashe Bar-Eli, Liat Anafi, Iris Barshack, Jacob Schachter, Rona Ortenberg, Gal Markel   +9 more
openaire   +3 more sources

ADAR1 Editing and its Role in Cancer [PDF]

Genes, 2018
It is well established that somatic mutations and escape of immune disruption are two essential factors in cancer initiation and progression. With an increasing number of second-generation sequencing data, transcriptomic modifications, so called RNA mutations, are emerging as significant forces that drive the transition from normal cell to malignant ...
Li-Di Xu, Marie Öhman
openaire   +2 more sources