Results 11 to 20 of about 4,773 (159)
The ADAR1 editome reveals drivers of editing-specificity for ADAR1-isoforms [PDF]
, 2021 Abstract Adenosine deaminase acting on RNA (ADAR) (also known as ADAR1) promotes A-to-I conversion in double-stranded and highly structured RNAs. ADAR1 has two isoforms transcribed from different promoters: ADAR1p150, which is mainly cytoplasmic and interferon-inducible, and constitutively expressed ADAR1p110 that is primarily localized
Renata Kleinova +6 more
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The ADAR1 editome reveals drivers of editing-specificity for ADAR1-isoforms
Nucleic Acids Research, 2023 Abstract Adenosine deaminase acting on RNA ADAR1 promotes A-to-I conversion in double-stranded and structured RNAs. ADAR1 has two isoforms transcribed from different promoters: cytoplasmic ADAR1p150 is interferon-inducible while ADAR1p110 is constitutively expressed and primarily localized in the nucleus.
Kleinova, Renata +9 more
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Substrate recognition by ADAR1 and ADAR2 [PDF]
RNA, 2001 RNA editing catalyzed by ADAR1 and ADAR2 involves the site-specific conversion of adenosine to inosine within imperfectly duplexed RNA. ADAR1- and ADAR2-mediated editing occurs within transcripts of glutamate receptors (GluR) in the brain and in hepatitis delta virus (HDV) RNA in the liver.
S K, Wong, S, Sato, D W, Lazinski
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ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation
Frontiers in Endocrinology, 2022 IntroductionEnterovirus infection has long been suspected as a possible trigger for type 1 diabetes. Upon infection, viral double-stranded RNA (dsRNA) is recognized by membrane and cytosolic sensors that orchestrate type I interferon signaling and the ...
Florian Szymczak +9 more
doaj +1 more source
PLoS Genetics, 2021 Adenosine deaminase acting on RNA 1 (ADAR1), an enzyme responsible for adenosine-to-inosine RNA editing, is composed of two isoforms: nuclear p110 and cytoplasmic p150.
Jung In Kim +11 more
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Expression and clinical significance of adenosine deaminase acting on RNA-1 in lung adenocarcinoma
Di-san junyi daxue xuebao, 2021 Objective To investigate the expression of adenosine deaminase acting on RNA-1 (ADAR1) in lung adenocarcinoma and its association with clinicopathological characteristics and prognosis.
YANG Wendi +4 more
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ADAR1-mediated regulation of melanoma invasion [PDF]
Nature Communications, 2018 AbstractMelanoma cells use different migratory strategies to exit the primary tumor mass and invade surrounding and subsequently distant tissues. We reported previously that ADAR1 expression is downregulated in metastatic melanoma, thereby facilitating proliferation.
Yael Nemlich +9 more
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ADAR1 and MicroRNA; A Hidden Crosstalk in Cancer [PDF]
International Journal of Molecular Sciences, 2017 The evolution of cancer cells is believed to be dependent on genetic or epigenetic alterations. However, this concept has recently been challenged by another mode of nucleotide alteration, RNA editing, which is frequently up-regulated in cancer. RNA editing is a biochemical process in which either Adenosine or Cytosine is deaminated by a group of RNA ...
Charles Cho +2 more
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ADAR1 restricts LINE-1 retrotransposition [PDF]
Nucleic Acids Research, 2016 Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosines to inosines in double-stranded RNAs. ADAR1 was demonstrated to be functional on different viruses exerting either antiviral or proviral effects. Concerning HIV-1, several studies showed that ADAR1 favors viral replication.
Orecchini, Elisa +9 more
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ADAR1 promotes systemic sclerosis via modulating classic macrophage activation
Frontiers in Immunology, 2022 IntroductionAs a multisystem autoimmune disorder disease, systemic sclerosis (SSc) is characterized by inflammation and fibrosis in the skin and other internal organs.
Chenming Sun +5 more
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