Results 1 to 10 of about 459,217 (330)

Advances in A-to-I RNA editing in cancer. [PDF]

Mol Cancer
RNA modifications are widespread throughout the mammalian transcriptome and play pivotal roles in regulating various cellular processes. These modifications are strongly linked to the development of many cancers.
Zhang Y, Li L, Mendoza JJ, Wang D, Yan Q, Shi L, Gong Z, Zeng Z, Chen P, Xiong W.   +9 more
europepmc   +4 more sources

Adaptation of A-to-I RNA editing in bacteria, fungi, and animals. [PDF]

Front Microbiol, 2023
Duan Y, Li H, Cai W.
europepmc   +4 more sources

Increased A-to-I RNA editing in atherosclerosis and cardiomyopathies. [PDF]

PLoS Comput Biol, 2023
Adenosine-to-inosine RNA editing is essential to prevent undesired immune activation. This diverse process alters the genetic content of the RNA and may recode proteins, change splice sites and miRNA targets, and mimic genomic mutations. Recent studies have associated or implicated aberrant editing with pathological conditions, including cancer ...
Mann TD, Kopel E, Eisenberg E, Levanon EY.   +3 more
europepmc   +5 more sources

The Integrative Studies on the Functional A-to-I RNA Editing Events in Human Cancers. [PDF]

Genomics Proteomics Bioinformatics, 2023
Adenosine-to-inosine (A-to-I) RNA editing, constituting nearly 90% of all RNA editing events in humans, has been reported to contribute to the tumorigenesis in diverse cancers.
Wu S, Fan Z, Kim P, Huang L, Zhou X.
europepmc   +2 more sources

Profiling A-to-I RNA editing during mouse somatic reprogramming at the single-cell level. [PDF]

Heliyon, 2023
Mouse somatic cells can be reprogrammed into induced pluripotent stem cells through a highly heterogeneous process regulated by numerous biological factors, including adenosine-to-inosine (A-to-I) RNA editing.
Lv T, Jiang S, Wang X, Hou Y.
europepmc   +2 more sources

Advances in Detection Methods for A-to-I RNA Editing. [PDF]

Wiley Interdiscip Rev RNA
ABSTRACTAdenosine‐to‐inosine (A‐to‐I) RNA editing is a key post‐transcriptional modification that influences gene expression and various cellular processes. Advances in sequencing technologies have greatly contributed to the identification of A‐to‐I editing sites, providing insights into their distribution across coding and non‐coding regions.
Yang Y, Sakurai M.
europepmc   +3 more sources

Conserved A-to-I RNA editing with non-conserved recoding expands the candidates of functional editing sites. [PDF]

Fly (Austin)
Adenosine-to-inosine (A-to-I) RNA editing recodes the genome and confers flexibility for the organisms to adapt to the environment. It is believed that RNA recoding sites are well suited for facilitating adaptive evolution by increasing the proteomic ...
Duan Y, Ma L, Zhao T, Liu J, Zheng C, Song F, Tian L, Cai W, Li H.   +8 more
europepmc   +2 more sources

Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing [PDF]

Cell Reports, 2020
Summary: Adenosine-to-inosine RNA editing is catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes that deaminate adenosine to inosine. Although many RNA editing sites are known, few trans regulators have been identified.
Emily C. Freund, Anne L. Sapiro, Qin Li, Sandra Linder, James J. Moresco, John R. Yates, III, Jin Billy Li   +6 more
doaj   +4 more sources

An orthology-based methodology as a complementary approach to retrieve evolutionarily conserved A-to-I RNA editing sites. [PDF]

RNA Biol
Adar-mediated adenosine-to-inosine (A-to-I) mRNA editing is a conserved mechanism that exerts diverse regulatory functions during the development, evolution, and adaptation of metazoans.
Liu J, Zhao T, Zheng C, Ma L, Song F, Tian L, Cai W, Li H, Duan Y.   +8 more
europepmc   +2 more sources

Dysregulated A to I RNA editing and non-coding RNAs in neurodegeneration [PDF]

Frontiers in Genetics, 2013
RNA editing is an alteration in the primary nucleotide sequences resulting from a chemical change in the base. RNA editing is observed in eukaryotic mRNA, tRNA, rRNA, and non-coding RNAs.
Minati eSingh
doaj   +3 more sources