Advances in A-to-I RNA editing in cancer [PDF]
Molecular CancerRNA modifications are widespread throughout the mammalian transcriptome and play pivotal roles in regulating various cellular processes. These modifications are strongly linked to the development of many cancers.
Yi Zhang +9 more
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Conserved A-to-I RNA editing with non-conserved recoding expands the candidates of functional editing sites [PDF]
FlyAdenosine-to-inosine (A-to-I) RNA editing recodes the genome and confers flexibility for the organisms to adapt to the environment. It is believed that RNA recoding sites are well suited for facilitating adaptive evolution by increasing the proteomic ...
Yuange Duan +8 more
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An orthology-based methodology as a complementary approach to retrieve evolutionarily conserved A-to-I RNA editing sites [PDF]
RNA BiologyAdar-mediated adenosine-to-inosine (A-to-I) mRNA editing is a conserved mechanism that exerts diverse regulatory functions during the development, evolution, and adaptation of metazoans.
Jiyao Liu +8 more
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Adaptation of A-to-I RNA editing in bacteria, fungi, and animals [PDF]
Frontiers in Microbiology, 2023 Yuange Duan, Hu Li, Wanzhi Cai
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The Many Roles of A-to-I RNA Editing in Animals: Functional or Adaptive?
Frontiers in Bioscience-Landmark, 2023 Metazoan adenosine-to-inosine (A-to-I) RNA editing is a highly conserved mechanism that diversifies the transcriptome by post-transcriptionally converting adenosine to inosine.
Dongwu Zhan +4 more
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L-GIREMI uncovers RNA editing sites in long-read RNA-seq
Genome Biology, 2023 Although long-read RNA-seq is increasingly applied to characterize full-length transcripts it can also enable detection of nucleotide variants, such as genetic mutations or RNA editing sites, which is significantly under-explored.
Zhiheng Liu +7 more
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The Integrative Studies on the Functional A-to-I RNA Editing Events in Human Cancers
Genomics, Proteomics & Bioinformatics, 2023 Adenosine-to-inosine (A-to-I) RNA editing, constituting nearly 90% of all RNA editing events in humans, has been reported to contribute to the tumorigenesis in diverse cancers.
Sijia Wu +4 more
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Uncovering Cis-Regulatory Elements Important for A-to-I RNA Editing in Fusarium graminearum
mBio, 2022 Adenosine-to-inosine (A-to-I) RNA editing independent of adenosine deaminase acting on RNA (ADAR) enzymes was discovered in fungi recently, and shown to be crucial for sexual reproduction. However, the underlying mechanism for editing is unknown.
Chanjing Feng +8 more
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Host A-to-I RNA editing signatures in intracellular bacterial and single-strand RNA viral infections
Frontiers in Immunology, 2023 BackgroundMicrobial infection is accompanied by remodeling of the host transcriptome. Involvement of A-to-I RNA editing has been reported during viral infection but remains to be elucidated during intracellular bacterial infections.ResultsHerein we ...
Zhi-Yuan Wei +30 more
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Zinc Finger RNA-Binding Protein Zn72D Regulates ADAR-Mediated RNA Editing in Neurons
Cell Reports, 2020 Summary: Adenosine-to-inosine RNA editing, catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes, alters RNA sequences from those encoded by DNA. These editing events are dynamically regulated, but few trans regulators of ADARs are known in vivo.
Anne L. Sapiro +8 more
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