Advances in A-to-I RNA editing in cancer [PDF]
Molecular CancerRNA modifications are widespread throughout the mammalian transcriptome and play pivotal roles in regulating various cellular processes. These modifications are strongly linked to the development of many cancers.
Yi Zhang +9 more
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Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system [PDF]
Frontiers in Neuroscience, 2013 The fine control of molecules mediating communication in the nervous system is key to adjusting neuronal responsiveness during development and in maintaining the stability of established networks in the face of altered sensory input.
Andrew Charles Penn +3 more
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A-to-I RNA editing: current knowledge sources and computational approaches with special emphasis on non-coding RNA molecules [PDF]
Frontiers in Bioengineering and Biotechnology, 2015 RNA editing is a dynamic mechanism for gene regulation attained through the alteration of the sequence of primary RNA transcripts. A-to-I (Adenosine-to-Inosine) RNA editing, which is catalyzed by members of the Adenosine Deaminase Acting on RNA (ADAR ...
Giovanni eNigita +2 more
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The Integrative Studies on the Functional A-to-I RNA Editing Events in Human Cancers [PDF]
Genomics, Proteomics & Bioinformatics, 2023 Adenosine-to-inosine (A-to-I) RNA editing, constituting nearly 90% of all RNA editing events in humans, has been reported to contribute to the tumorigenesis in diverse cancers.
Sijia Wu +4 more
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Population and allelic variation of A-to-I RNA editing in human transcriptomes [PDF]
Genome Biology, 2017 Background A-to-I RNA editing is an important step in RNA processing in which specific adenosines in some RNA molecules are post-transcriptionally modified to inosines.
Eddie Park +6 more
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Profiling A-to-I RNA editing during mouse somatic reprogramming at the single-cell level [PDF]
Heliyon, 2023 Mouse somatic cells can be reprogrammed into induced pluripotent stem cells through a highly heterogeneous process regulated by numerous biological factors, including adenosine-to-inosine (A-to-I) RNA editing.
Tianhang Lv +3 more
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Conserved A-to-I RNA editing with non-conserved recoding expands the candidates of functional editing sites [PDF]
FlyAdenosine-to-inosine (A-to-I) RNA editing recodes the genome and confers flexibility for the organisms to adapt to the environment. It is believed that RNA recoding sites are well suited for facilitating adaptive evolution by increasing the proteomic ...
Yuange Duan +8 more
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An orthology-based methodology as a complementary approach to retrieve evolutionarily conserved A-to-I RNA editing sites [PDF]
RNA BiologyAdar-mediated adenosine-to-inosine (A-to-I) mRNA editing is a conserved mechanism that exerts diverse regulatory functions during the development, evolution, and adaptation of metazoans.
Jiyao Liu +8 more
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Adaptation of A-to-I RNA editing in bacteria, fungi, and animals [PDF]
Frontiers in Microbiology, 2023 Yuange Duan, Hu Li, Wanzhi Cai
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The Many Roles of A-to-I RNA Editing in Animals: Functional or Adaptive?
Frontiers in Bioscience-Landmark, 2023 Metazoan adenosine-to-inosine (A-to-I) RNA editing is a highly conserved mechanism that diversifies the transcriptome by post-transcriptionally converting adenosine to inosine.
Dongwu Zhan +4 more
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