Alternative splicing and extensive RNA editing of human TPH2 transcripts. [PDF]
, 2010 Brain serotonin (5-HT) neurotransmission plays a key role in the regulation of mood and has been implicated in a variety of neuropsychiatric conditions. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of 5-HT.
Bondy, Brigitta +59 more
core +1 more source
C-to-U RNA Editing: A Site Directed RNA Editing Tool for Restoration of Genetic Code
, 2022 The restoration of genetic code by editing mutated genes is a potential method for the treatment of genetic diseases/disorders. Genetic disorders are caused by the point mutations of thymine (T) to cytidine (C) or guanosine (G) to adenine (A), for which ...
Sonali Bhakta +3 more
core +1 more source
The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers
Cancer Cell, 2015 Summary Adenosine-to-inosine (A-to-I) RNA editing is a widespread post-transcriptional mechanism, but its genomic landscape and clinical relevance in cancer have not been investigated systematically.
Leng Han +23 more
semanticscholar +1 more source
Identification of novel components of Trypanosoma brucei editosomes [PDF]
, 2003 The editosome is a multiprotein complex that catalyzes the insertion and deletion of uridylates that occurs during RNA editing in trypanosomatids. We report the identification of nine novel editosome proteins in Trypanosoma brucei.
Schnaufer, Achim; id_orcid +6 more
core +1 more source
Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system
Frontiers in Neuroscience, 2013 The fine control of molecules mediating communication in the nervous system is key to adjusting neuronal responsiveness during development and in maintaining the stability of established networks in the face of altered sensory input.
Andrew Charles Penn +3 more
doaj +1 more source
A hierarchy in clusters of cephalopod mRNA editing sites
Scientific Reports, 2022 RNA editing in the form of substituting adenine with inosine (A-to-I editing) is the most frequent type of RNA editing in many metazoan species. In most species, A-to-I editing sites tend to form clusters and editing at clustered sites depends on editing
Mikhail A. Moldovan +3 more
doaj +1 more source
Brain Epitranscriptomic Analysis Revealed Altered A-to-I RNA Editing in Septic Patients
Frontiers in Genetics, 2022 Recent studies suggest that RNA editing is associated with impaired brain function and neurological and psychiatric disorders. However, the role of A-to-I RNA editing during sepsis-associated encephalopathy (SAE) remains unclear.
Jing-Qian Zhang +22 more
doaj +1 more source
Widespread A-to-I RNA Editing of Alu-Containing mRNAs in the Human Transcriptome
PLoS Biology, 2004 RNA editing by adenosine deamination generates RNA and protein diversity through the posttranscriptional modification of single nucleotides in RNA sequences.
A. Athanasiadis, A. Rich, S. Maas
semanticscholar +1 more source
Editosome Accessory Factors KREPB9 and KREPB10 in Trypanosoma brucei [PDF]
, 2012 Multiprotein complexes, called editosomes, catalyze the uridine insertion and deletion RNA editing that forms translatable mitochondrial mRNAs in kinetoplastid parasites.
Acestor, Nathalie +5 more
core +1 more source
N6-Methyladenosines Modulate A-to-I RNA Editing [PDF]
Molecular Cell, 2018 N6-methyladenosine (m6A) and adenosine-to-inosine (A-to-I) editing are two of the most abundant RNA modifications, both at adenosines. Yet, the interaction of these two types of adenosine modifications is largely unknown. Here we show a global A-to-I difference between m6A-positive and m6A-negative RNA populations.
Jian-Feng, Xiang +5 more
openaire +2 more sources