Results 41 to 50 of about 590,857 (293)

Changes in ADAR RNA editing patterns in CMV and ZIKV congenital infections

BMC Genomics, 2023
Background RNA editing is a process that increases transcriptome diversity, often through Adenosine Deaminases Acting on RNA (ADARs) that catalyze the deamination of adenosine to inosine.
Benjamin Wales-McGrath, Heather Mercer, Helen Piontkivska   +2 more
doaj   +1 more source

ADAR2-dependent RNA editing of GluR2 is involved in thiamine deficiency-induced alteration of calcium dynamics [PDF]

, 2010
Background Thiamine (vitamin B1) deficiency (TD) causes mild impairment of oxidative metabolism and region-selective neuronal loss in the central nervous system (CNS). TD in animals has been used to model aging-associated neurodegeneration in
Chun Feng, Guang Yang, Jia Luo, Jing Xu, Liyun Zhao, Shuchen Lee, Xiaomin Zhang, Yanjie Wan, Ying Liu, Yong Liu, Yue Yong, Zhiqin Fan, Zun-Ji Ke   +12 more
core   +3 more sources

Characterization of RNA Editome in the Mammary Gland of Yaks during the Lactation and Dry Periods

Animals, 2022
The mammary gland is a complicated organ comprising several types of cells, and it undergoes extensive morphogenetic and metabolic changes during the female reproductive cycle.
Xiaoyun Wu, Wondossen Ayalew, Min Chu, Jie Pei, Chunnian Liang, Pengjia Bao, Xian Guo, Ping Yan   +7 more
doaj   +1 more source

RNA editing signature during myeloid leukemia cell differentiation [PDF]

, 2017
Adenosine deaminases acting on RNA (ADARs) are key proteins for hematopoietic stem cell self-renewal and for survival of differentiating progenitor cells. However, their specific role in myeloid cell maturation has been poorly investigated.
A Athanasiadis, A Gallo, AS Shifera, BE Wulff, BJ Liddicoat, BL Bass, C Cenci, C Sundstrom, C Trapnell, C Trapnell, D Laxminarayana, E Picardi, E Picardi, G Camilli, H Aberle, H Li, JB Patterson, JC Hartner, JH Bahn, JM Desterro, Justin M. Thomas, K Nishikura, L Bazak, L Chen, M D'Antonio, M Daigneault, M Higuchi, M Vogler, MA Zipeto, MA Zipeto, N Mannion, N Paz-Yaacov, Q Jiang, Q Wang, Q Wang, R Marcucci, R XuFeng, RA Steinman, RJ Orlowski, S Tomaselli, S Tomaselli, T Hwang, TD Wu, TR Dawson, W Slotkin, Y Li, Y Pinto, YJ Crow, YS Baek   +48 more
core   +2 more sources

Solution structure of the N-terminal dsRBD of Drosophila ADAR and interaction studies with RNA [PDF]

, 2012
Adenosine deaminases that act on RNA (ADAR) catalyze adenosine to inosine (A-to-I) editing in double-stranded RNA (dsRNA) substrates. Inosine is read as guanosine by the translation machinery; therefore A-to-I editing events in coding sequences may ...
Barraud, Barraud, Barraud, Bass, Bhalla, Blaszczyk, Bratt, Bret S.E. Heale, Brunger, Brunger, Burns, Bycroft, Chang, Cho, DeLano, Dominguez, Duss, Eggington, Fierro-Monti, Frédéric H.-T. Allain, Gallo, Gan, Goddard, Graveley, Guntert, Guntert, Herrmann, Herrmann, Higuchi, Hood, Hoopengardner, Keegan, Keegan, Kharrat, Krovat, Laskowski, Lehmann, Leulliot, Lomeli, Maas, Macbeth, Mary A. O’Connell, Nishikura, Palladino, Palladino, Paro, Pierre Barraud, Ramos, Ryter, Saunders, Sommer, Stapleton, Stefl, Stefl, Stefl, Stephens, Valente, Wang, Wu, Yang   +59 more
core   +4 more sources

Adaptation of A-to-I RNA editing in Drosophila

PLOS Genetics, 2017
Adenosine-to-inosine (A-to-I) editing is hypothesized to facilitate adaptive evolution by expanding proteomic diversity through an epigenetic approach. However, it is challenging to provide evidences to support this hypothesis at the whole editome level.
Yuange Duan, Shengqian Dou, Shiqi Luo, Hong Zhang, Jian Lu   +4 more
openaire   +4 more sources

RESIC: A Tool for Comprehensive Adenosine to Inosine RNA Editing Site Identification and Classification

Frontiers in Genetics, 2021
Adenosine to inosine (A-to-I) RNA editing, the most prevalent type of RNA editing in metazoans, is carried out by adenosine deaminases (ADARs) in double-stranded RNA regions.
Dean Light, Roni Haas, Mahmoud Yazbak, Tal Elfand, Tal Blau, Ayelet T. Lamm   +5 more
doaj   +1 more source

Actions of Agonists, Fipronil and Ivermectin on the Predominant In Vivo Splice and Edit Variant (RDLbd, I/V) of the Drosophila GABA Receptor Expressed in Xenopus laevis Oocytes [PDF]

, 2014
Ionotropic GABA receptors are the targets for several classes of insecticides. One of the most widely-studied insect GABA receptors is RDL (resistance to dieldrin), originally isolated from Drosophila melanogaster.
Biggin, P, Buckingham, SD, Lees, K, Musgaard, M, Sattelle, D, Suwanmanee, S   +5 more
core   +3 more sources

CRISPR/Cas9‐mediated genome editing: from basic research to translational medicine [PDF]

, 2020
The recent development of the CRISPR/Cas9 system as an efficient and accessible programmable genome-editing tool has revolutionized basic science research. CRISPR/Cas9 system-based technologies have armed researchers with new powerful tools to unveil the
Ferreira, B I, Jacinto, Filipe, Link, Wolfgang   +2 more
core   +1 more source

Knowledge in the Investigation of A-to-I RNA Editing Signals [PDF]

Frontiers in Bioengineering and Biotechnology, 2015
RNA editing is a post-transcriptional alteration of RNA sequences that is able to affect protein structure as well as RNA and protein expression. Adenosine-to-inosine (A-to-I) RNA editing is the most frequent and common post-transcriptional modification in human, where adenosine (A) deamination produces its conversion into inosine (I), which in turn is
Nigita G, Alaimo S, FERRO, Alfredo, Giugno R, PULVIRENTI, ALFREDO   +4 more
openaire   +3 more sources