Results 61 to 70 of about 590,857 (293)

RNA editing regulates insect gamma-aminobutyric acid receptor function and insecticide sensitivity [PDF]

, 2008
A-to-I pre-mRNA editing by adenosine deaminase enzymes has been reported to enhance protein diversity in the nervous system. In Drosophila, the resistance to dieldrin (RDL) gamma-aminobutyric acid (GABA) receptor subunit displays an editing site (R122 ...
A. Hamon, B. Lapied, G. Le Goff, Z. Es-Salah-Lamoureux   +3 more
core   +3 more sources

Conservation of A-to-I RNA editing in bowhead whale and pig

PLoS ONE, 2021
RNA editing is a post-transcriptional process in which nucleotide changes are introduced into an RNA sequence, many of which can contribute to proteomic sequence variation.
Knud Larsen, Mads Peter Heide-Jørgensen
doaj   +3 more sources

Differential Enzymatic Activity of Rat ADAR2 Splicing Variants Is Due to Altered Capability to Interact with RNA in the Deaminase Domain [PDF]

, 2018
In mammals, adenosine (A) to inosine (I) RNA editing is performed by adenosine deaminases acting on RNA (ADAR), ADAR1 and ADAR2 enzymes, encoded by mRNAs that might undergo splicing process.
Barbon, Alessandro, Bonini, Daniela, Colombi, Marina, Filippini, Alice, Gangemi, Fabrizio, Giacopuzzi, Edoardo, La Via, Luca   +6 more
core   +2 more sources

Genome-Wide Identification of RNA Editing Sites Affecting Intramuscular Fat in Pigs

Animals, 2020
Intramuscular fat (IMF) is essential for improving the palatability and flavor of meat, and it is strongly associated with human insulin resistance. RNA editing is a widespread regulating event in different tissues.
Ligang Wang, Jingna Li, Xinhua Hou, Hua Yan, Longchao Zhang, Xin Liu, Hongmei Gao, Fuping Zhao, Lixian Wang   +8 more
doaj   +1 more source

Zalpha-domains: At the intersection between RNA editing and innate immunity [PDF]

, 2012
The involvement of A to I RNA editing in antiviral responses was first indicated by the observation of genomic hyper-mutation for several RNA viruses in the course of persistent infections.
Athanasiadis, Alekos
core   +1 more source

Modulating signaling networks by CRISPR/Cas9-mediated transposable element insertion [PDF]

, 2018
In a recent past, transposable elements (TEs) were referred to as selfish genetic components only capable of copying themselves with the aim of increasing the odds of being inherited.
A Bolotin, A Burt, A Hammond, AP Lorenzetti, B McClintock, BA Castilho, C Feschotte, C Feschotte, C Feschotte, C Kettlun, C Lu, C Ye, CN Hancock, DBT Cox, DJ Garfinkel, F Palazzoli, FA Ran, FJM Mojica, G Feng, G Mai, G Yang, H Kuang, H Mao, HT Dong, IK Jordan, J Hou, J Li, J Paszkowski, JA Doudna, JB Owens, JD Hollister, JE DiCarlo, JI Qüesta, JK Baillie, JM Casacuberta, K Kikuchi, K Naito, K Naito, K Shirasawa, KD Kim, KM Esvelt, KS Makarova, L Bortesi, L Cong, LC Li, LM Vaschetto, Luis María Vaschetto, M Cowley, M Jinek, M Momose, M Patel, M Szabo, M Turner, N Buchon, N Jiang, N Jiang, N Jiang, Q Zhang, R Barrangou, R Jansen, RM Walsh, SD Molyneux, SR Wessler, SR Yant, T Mourier, T Sakuma, T Singer, VM Gantz, W Matsunaga, WC Lai, X Li, X Li, X Lin, X Shan, Y Ishino, Y Yan, ZN Adelman   +76 more
core   +1 more source

Is abundant A-to-I RNA editing primate-specific? [PDF]

Trends in Genetics, 2005
preprint version; final version available at http://dx.doi.org/10.1016/j.tig.2004.12 ...
Eisenberg, Eli, Nemzer, Sergey, Kinar, Yaron, Sorek, Rotem, Rechavi, Gideon, Levanon, Erez Y.   +5 more
openaire   +3 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

A-to-I mRNA Editing in a Ferric Siderophore Receptor Improves Competition for Iron in Xanthomonas oryzae pv. oryzicola

Microbiology Spectrum, 2021
Iron is an essential element for the growth and survival of pathogenic bacteria; however, it is not fully understood how bacteria sense and respond to iron deficiency or excess. In this study, we show that xfeA in Xanthomonas oryzae pv.
Wenhan Nie, Sai Wang, Jin Huang, Qin Xu, Peihong Wang, Yan Wu, Rui He, Ayizekeranmu Yiming, Jingling Liang, Iftikhar Ahmad, Luoyi Fu, Longbiao Guo, Junhua Yuan, Bo Zhu, Gongyou Chen   +14 more
doaj   +1 more source

A-to-I RNA editing does not change with age in the healthy male rat brain [PDF]

, 2013
RNA editing is a post-transcriptional process, which results in base substitution modifications to RNA. It is an important process in generating protein diversity through amino acid substitution and the modulation of splicing events.
Andrew P. Holmes, Brian J. Merry, João Pedro de Magalhães, Shona H. Wood   +3 more
core   +1 more source