Results 51 to 60 of about 590,857 (293)

A comprehensive study on cellular RNA editing activity in response to infections with different subtypes of influenza a viruses

BMC Genomics, 2018
Background RNA editing is an important mechanism that expands the diversity and complexity of genetic codes. The conversions of adenosine (A) to inosine (I) and cytosine (C) to uridine (U) are two prominent types of RNA editing in animals.
Yingying Cao, Ruiyuan Cao, Yaowei Huang, Hongxia Zhou, Yuanhua Liu, Xuan Li, Wu Zhong, Pei Hao   +7 more
doaj   +1 more source

A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection [PDF]

, 2012
The innate immune response provides the first line of defense against viruses and other pathogens by responding to specific microbial molecules. Influenza A virus (IAV) produces double-stranded RNA as an intermediate during the replication life cycle ...
Maelfait, Jonathan, Roose, Kenny, Bogaert, Pieter, Sze, Mozes, Saelens, Xavier, Pasparakis, Manolis, Carpentier, Isabelle, van Loo, Geert, Beyaert, Rudi   +8 more
core   +2 more sources

Recommendations for detection, validation, and evaluation of RNA editing events in cardiovascular and neurological/neurodegenerative diseases

Molecular Therapy: Nucleic Acids
RNA editing, a common and potentially highly functional form of RNA modification, encompasses two different RNA modifications, namely adenosine to inosine (A-to-I) and cytidine to uridine (C-to-U) editing. As inosines are interpreted as guanosines by the
Korina Karagianni, Alessia Bibi, Alisia Madé, Shubhra Acharya, Mikko Parkkonen, Teodora Barbalata, Prashant K. Srivastava, David de Gonzalo-Calvo, Constanza Emanueli, Fabio Martelli, Yvan Devaux, Dimitra Dafou, A. Yaël Nossent   +12 more
doaj   +1 more source

Systematic identification of edited microRNAs in the human brain [PDF]

, 2012
Adenosine-to-inosine (A-to-I) editing modifies RNA transcripts from their genomic blueprint. A prerequisite for this process is a double-stranded RNA (dsRNA) structure.
Alon, Shahar, Church, George M., Eisenberg, Eli, Galeano, Federica, Gallo, Angela, Locatelli, Franco, Mor, Eyal, Shomron, Noam, Vigneault, Francois   +8 more
core   +1 more source

Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools. [PDF]

, 2020
Appropriate empirical-based evidence and detailed theoretical considerations should be used for evolutionary explanations of phenotypic variation observed in the field of human population genetics (especially Indigenous populations). Investigators within
Fox, Keolu, Komor, Alexis C, Rallapalli, Kartik Lakshmi   +2 more
core   +2 more sources

A-to-I RNA editing and hematopoiesis

Experimental Hematology
Adenosine-to-inosine (A-to-I) RNA editing plays essential roles in modulating normal development and homeostasis. This process is catalyzed by adenosine deaminase acting on RNA (ADAR) family proteins. The most well-understood biological processes modulated by A-to-I editing are innate immunity and neurological development, attributed to ADAR1 and ADAR2,
Zhen, Liang, Carl R, Walkley, Jacki E, Heraud-Farlow   +2 more
openaire   +2 more sources

Reovirus infection induces transcriptome-wide unique A-to-I editing changes in the murine fibroblasts.

Virus Research
The conversion of Adenosine (A) to Inosine (I), by Adenosine Deaminases Acting on RNA or ADARs, is an essential post-transcriptional modification that contributes to proteome diversity and regulation in metazoans including humans.
Ayesha Tariq, Helen Piontkivska
doaj   +1 more source

Developmental stage-specific A-to-I editing pattern in the postnatal pineal gland of pigs (Sus scrofa)

Journal of Animal Science and Biotechnology, 2020
Background RNA editing is a widespread post-transcriptional modification mechanism in mammalian genomes. Although many editing sites have been identified in domestic pigs (Sus scrofa), little is known about the characteristics and dynamic regulation of ...
Rong Zhou, Wenye Yao, Chundi Xie, Leixia Zhang, Yangli Pei, Hua Li, Zheng Feng, Yalan Yang, Kui Li   +8 more
doaj   +1 more source

Large-scale analysis of structural, sequence and thermodynamic characteristics of A-to-I RNA editing sites in human Alu repeats [PDF]

, 2010
Background Alu repeats in the human transcriptome undergo massive adenosine to inosine RNA editing. This process is selective, as editing efficiency varies greatly among different adenosines.
Yoav Kleinberger, Eli Eisenberg
core   +2 more sources

Discriminative Prediction of A-To-I RNA Editing Events from DNA Sequence. [PDF]

PLoS ONE, 2016
RNA editing is a post-transcriptional alteration of RNA sequences that, via insertions, deletions or base substitutions, can affect protein structure as well as RNA and protein expression.
Jiangming Sun, Yang De Marinis, Peter Osmark, Pratibha Singh, Annika Bagge, Bérengère Valtat, Petter Vikman, Peter Spégel, Hindrik Mulder   +8 more
doaj   +1 more source