Results 31 to 40 of about 134,460,322 (302)
Identification of novel components of Trypanosoma brucei editosomes [PDF]
, 2003 The editosome is a multiprotein complex that catalyzes the insertion and deletion of uridylates that occurs during RNA editing in trypanosomatids. We report the identification of nine novel editosome proteins in Trypanosoma brucei.
Schnaufer, Achim; id_orcid +6 more
core +1 more source
The evolution and adaptation of A-to-I RNA editing
PLOS Genetics, 2017 Adenosine-to-inosine (A-to-I) RNA editing is an important post-transcriptional modification that affects the information encoded from DNA to RNA to protein. RNA editing can generate a multitude of transcript isoforms and can potentially be used to optimize protein function in response to varying conditions.
Arielle L. Yablonovitch +3 more
openaire +4 more sources
Editosome Accessory Factors KREPB9 and KREPB10 in Trypanosoma brucei [PDF]
, 2012 Multiprotein complexes, called editosomes, catalyze the uridine insertion and deletion RNA editing that forms translatable mitochondrial mRNAs in kinetoplastid parasites.
Acestor, Nathalie +5 more
core +1 more source
Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system
Frontiers in Neuroscience, 2013 The fine control of molecules mediating communication in the nervous system is key to adjusting neuronal responsiveness during development and in maintaining the stability of established networks in the face of altered sensory input.
Andrew Charles Penn +3 more
doaj +1 more source
N6-Methyladenosines Modulate A-to-I RNA Editing [PDF]
Molecular Cell, 2018 N6-methyladenosine (m6A) and adenosine-to-inosine (A-to-I) editing are two of the most abundant RNA modifications, both at adenosines. Yet, the interaction of these two types of adenosine modifications is largely unknown. Here we show a global A-to-I difference between m6A-positive and m6A-negative RNA populations.
Jian-Feng, Xiang +5 more
openaire +2 more sources
RNA-specific ribonucleotidyl transferases [PDF]
, 2007 RNA-specific nucleotidyl transferases (rNTrs) are a diverse family of template-independent polymerases that add ribonucleotides to the 3'-ends of RNA molecules.
Keller, W. +3 more
core +1 more source
The majority of A-to-I RNA editing is not required for mammalian homeostasis
Genome Biology, 2019 Background Adenosine-to-inosine (A-to-I) RNA editing, mediated by ADAR1 and ADAR2, occurs at tens of thousands to millions of sites across mammalian transcriptomes.
Alistair M. Chalk +3 more
doaj +1 more source
A Role for A-to-I RNA Editing in Temperature Adaptation [PDF]
Physiology, 2012 A-to-I RNA editing can recode mRNAs, giving organisms the option to express diverse, functionally distinct protein isoforms. Here, we propose that RNA editing is inherently geared for temperature adaptation because it tends to recode to smaller, less stabilizing amino acids. Studies on how editing affects protein function support this idea.
Sandra C, Garrett, Joshua J C, Rosenthal
openaire +2 more sources
Increased adenosine-to-inosine RNA editing in rheumatoid arthritis [PDF]
, 2020 Objective: Adenosine-to-inosine (A-to-I) RNA editing of Alu retroelements is a primate-specific mechanism mediated by adenosine deaminases acting on RNA (ADARs) that diversifies transcriptome by changing selected nucleotides in RNA molecules.
Stellos, K. +7 more
core +1 more source
Adaptation of A-to-I RNA editing in Drosophila
PLOS Genetics, 2017 Adenosine-to-inosine (A-to-I) editing is hypothesized to facilitate adaptive evolution by expanding proteomic diversity through an epigenetic approach. However, it is challenging to provide evidences to support this hypothesis at the whole editome level.
Yuange Duan +4 more
openaire +4 more sources