Results 11 to 20 of about 590,857 (293)

A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer [PDF]

Cancer Cell, 2018
Adenosine (A) to inosine (I) RNA editing introduces many nucleotide changes in cancer transcriptomes. However, due to the complexity of post-transcriptional regulation, the contribution of RNA editing to proteomic diversity in human cancers remains unclear. Here, we performed an integrated analysis of TCGA genomic data and CPTAC proteomic data. Despite
Xinxin, Peng, Xiaoyan, Xu, Yumeng, Wang, David H, Hawke, Shuangxing, Yu, Leng, Han, Zhicheng, Zhou, Kamalika, Mojumdar, Kang Jin, Jeong, Marilyne, Labrie, Yiu Huen, Tsang, Minying, Zhang, Yiling, Lu, Patrick, Hwu, Kenneth L, Scott, Han, Liang, Gordon B, Mills   +16 more
openaire   +4 more sources

Dysregulated A to I RNA editing and non-coding RNAs in neurodegeneration [PDF]

Frontiers in Genetics, 2013
RNA editing is an alteration in the primary nucleotide sequences resulting from a chemical change in the base. RNA editing is observed in eukaryotic mRNA, tRNA, rRNA, and non-coding RNAs.
Minati eSingh
doaj   +3 more sources

Systematically Characterizing A-to-I RNA Editing Neoantigens in Cancer [PDF]

Frontiers in Oncology, 2020
A-to-I RNA editing can contribute to the transcriptomic and proteomic diversity of many diseases including cancer. It has been reported that peptides generated from RNA editing could be naturally presented by human leukocyte antigen (HLA) molecules and ...
Chi Zhou, Zhiting Wei, Liye Zhang, Zhaoyi Yang, Qi Liu   +4 more
doaj   +3 more sources

Increased A-to-I RNA editing in atherosclerosis and cardiomyopathies. [PDF]

PLoS Comput Biol, 2023
Adenosine-to-inosine RNA editing is essential to prevent undesired immune activation. This diverse process alters the genetic content of the RNA and may recode proteins, change splice sites and miRNA targets, and mimic genomic mutations. Recent studies have associated or implicated aberrant editing with pathological conditions, including cancer ...
Mann TD, Kopel E, Eisenberg E, Levanon EY.   +3 more
europepmc   +5 more sources

The cell line A-to-I RNA editing catalogue [PDF]

Nucleic Acids Research, 2020
Abstract Adenosine-to-inosine (A-to-I) RNA editing is a common post transcriptional modification. It has a critical role in protecting against false activation of innate immunity by endogenous double stranded RNAs and has been associated with various regulatory processes and diseases such as autoimmune and cardiovascular diseases as well
Eli Eisenberg, Erez Y Levanon, Ernesto Picardi, Ayal Hendel, Eli Kopel, Amos A Schaffer   +5 more
openaire   +3 more sources

Substitutional A‐to‐I RNA editing [PDF]

WIREs RNA, 2010
AbstractAdenosine‐to‐inosine (A‐to‐I) editing catalyzed by adenosine deaminases acting on RNA (ADARs) entails the chemical conversion of adenosine residues to inosine residues within double‐stranded RNA (dsRNA) substrates. Inosine base pairs as guanosine and A‐to‐I editing can therefore alter the structure and base pairing properties of the RNA ...
Bjorn-Erik, Wulff, Kazuko, Nishikura
openaire   +2 more sources

Elevated A-to-I RNA editing in COVID-19 infected individuals. [PDF]

NAR Genom Bioinform, 2023
Abstract Given the current status of coronavirus disease 2019 (COVID-19) as a global pandemic, it is of high priority to gain a deeper understanding of the disease's development and how the virus impacts its host. Adenosine (A)-to-Inosine (I) RNA editing is a post-transcriptional modification, catalyzed by the ADAR family of enzymes ...
Merdler-Rabinowicz R, Gorelik D, Park J, Meydan C, Foox J, Karmon M, Roth HS, Cohen-Fultheim R, Shohat-Ophir G, Eisenberg E, Ruppin E, Mason CE, Levanon EY.   +12 more
europepmc   +3 more sources

Advances in Detection Methods for A-to-I RNA Editing. [PDF]

Wiley Interdiscip Rev RNA
ABSTRACTAdenosine‐to‐inosine (A‐to‐I) RNA editing is a key post‐transcriptional modification that influences gene expression and various cellular processes. Advances in sequencing technologies have greatly contributed to the identification of A‐to‐I editing sites, providing insights into their distribution across coding and non‐coding regions.
Yang Y, Sakurai M.
europepmc   +3 more sources

N6-Methyladenosines Modulate A-to-I RNA Editing [PDF]

Molecular Cell, 2018
N6-methyladenosine (m6A) and adenosine-to-inosine (A-to-I) editing are two of the most abundant RNA modifications, both at adenosines. Yet, the interaction of these two types of adenosine modifications is largely unknown. Here we show a global A-to-I difference between m6A-positive and m6A-negative RNA populations.
Jian-Feng, Xiang, Qin, Yang, Chu-Xiao, Liu, Man, Wu, Ling-Ling, Chen, Li, Yang   +5 more
openaire   +2 more sources

De Novo A-to-I RNA Editing Discovery in lncRNA [PDF]

Cancers, 2020
Background: Adenosine to inosine (A-to-I) RNA editing is the most frequent editing event in humans. It converts adenosine to inosine in double-stranded RNA regions (in coding and non-coding RNAs) through the action of the adenosine deaminase acting on RNA (ADAR) enzymes.
Silvestris D. A., Scopa C., Hanchi S., Locatelli F., Gallo A.   +4 more
openaire   +3 more sources