Results 11 to 20 of about 134,460,322 (302)

The cell line A-to-I RNA editing catalogue [PDF]

Nucleic Acids Research, 2020
Abstract Adenosine-to-inosine (A-to-I) RNA editing is a common post transcriptional modification. It has a critical role in protecting against false activation of innate immunity by endogenous double stranded RNAs and has been associated with various regulatory processes and diseases such as autoimmune and cardiovascular diseases as well
Eli Eisenberg, Erez Y Levanon, Ernesto Picardi, Ayal Hendel, Eli Kopel, Amos A Schaffer   +5 more
openaire   +5 more sources

Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing [PDF]

Cell Reports, 2020
Summary: Adenosine-to-inosine RNA editing is catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes that deaminate adenosine to inosine. Although many RNA editing sites are known, few trans regulators have been identified.
Emily C. Freund, Anne L. Sapiro, Qin Li, Sandra Linder, James J. Moresco, John R. Yates, III, Jin Billy Li   +6 more
doaj   +4 more sources

De Novo A-to-I RNA Editing Discovery in lncRNA [PDF]

Cancers, 2020
Background: Adenosine to inosine (A-to-I) RNA editing is the most frequent editing event in humans. It converts adenosine to inosine in double-stranded RNA regions (in coding and non-coding RNAs) through the action of the adenosine deaminase acting on RNA (ADAR) enzymes.
Silvestris D. A., Scopa C., Hanchi S., Locatelli F., Gallo A.   +4 more
openaire   +5 more sources

Dysregulated A to I RNA editing and non-coding RNAs in neurodegeneration [PDF]

Frontiers in Genetics, 2013
RNA editing is an alteration in the primary nucleotide sequences resulting from a chemical change in the base. RNA editing is observed in eukaryotic mRNA, tRNA, rRNA, and non-coding RNAs.
Minati eSingh
doaj   +3 more sources

Discriminative Prediction of A-To-I RNA Editing Events from DNA Sequence. [PDF]

PLoS ONE, 2016
RNA editing is a post-transcriptional alteration of RNA sequences that, via insertions, deletions or base substitutions, can affect protein structure as well as RNA and protein expression.
Jiangming Sun, Yang De Marinis, Peter Osmark, Pratibha Singh, Annika Bagge, Bérengère Valtat, Petter Vikman, Peter Spégel, Hindrik Mulder   +8 more
doaj   +2 more sources

Reduction of RNA A-to-I editing in Drosophila acclimated to heat shock

Kaohsiung Journal of Medical Sciences, 2013
Although an increasing number of RNA adenosine-to-inosine (A-to-I) editing sites are being discovered, how the editing frequencies of these sites are modulated to fine-tune protein function in adaptive responses is not well understood.
Joel Stocker, Hurng-Wern Huang, Hong-Ming Wang, Hsueh-Wei Chang, Chien-Chih Chiu, Chung-Lung Cho, Chao-Neng Tseng   +6 more
doaj   +4 more sources

Increased A-to-I RNA editing in atherosclerosis and cardiomyopathies. [PDF]

PLoS Comput Biol, 2023
Adenosine-to-inosine RNA editing is essential to prevent undesired immune activation. This diverse process alters the genetic content of the RNA and may recode proteins, change splice sites and miRNA targets, and mimic genomic mutations. Recent studies have associated or implicated aberrant editing with pathological conditions, including cancer ...
Mann TD, Kopel E, Eisenberg E, Levanon EY.   +3 more
europepmc   +6 more sources

Substitutional A‐to‐I RNA editing [PDF]

WIREs RNA, 2010
AbstractAdenosine‐to‐inosine (A‐to‐I) editing catalyzed by adenosine deaminases acting on RNA (ADARs) entails the chemical conversion of adenosine residues to inosine residues within double‐stranded RNA (dsRNA) substrates. Inosine base pairs as guanosine and A‐to‐I editing can therefore alter the structure and base pairing properties of the RNA ...
Bjorn-Erik, Wulff, Kazuko, Nishikura
openaire   +2 more sources

A-to-I RNA Editing and Human Disease [PDF]

RNA Biology, 2006
The post-transcriptional modification of mammalian transcripts by A-to-I RNA editing has been recognized as an important mechanism for the generation of molecular diversity and also regulates protein function through recoding of genomic information.
Stefan, Maas, Yukio, Kawahara, Kristen M, Tamburro, Kazuko, Nishikura   +3 more
openaire   +2 more sources

Advances in Detection Methods for A-to-I RNA Editing. [PDF]

Wiley Interdiscip Rev RNA
ABSTRACTAdenosine‐to‐inosine (A‐to‐I) RNA editing is a key post‐transcriptional modification that influences gene expression and various cellular processes. Advances in sequencing technologies have greatly contributed to the identification of A‐to‐I editing sites, providing insights into their distribution across coding and non‐coding regions.
Yang Y, Sakurai M.
europepmc   +3 more sources