Results 11 to 20 of about 459,217 (330)

The cell line A-to-I RNA editing catalogue [PDF]

Nucleic Acids Research, 2020
Abstract Adenosine-to-inosine (A-to-I) RNA editing is a common post transcriptional modification. It has a critical role in protecting against false activation of innate immunity by endogenous double stranded RNAs and has been associated with various regulatory processes and diseases such as autoimmune and cardiovascular diseases as well
Eli Eisenberg, Erez Y Levanon, Ernesto Picardi, Ayal Hendel, Eli Kopel, Amos A Schaffer   +5 more
semanticscholar   +6 more sources

De Novo A-to-I RNA Editing Discovery in lncRNA [PDF]

Cancers, 2020
Background: Adenosine to inosine (A-to-I) RNA editing is the most frequent editing event in humans. It converts adenosine to inosine in double-stranded RNA regions (in coding and non-coding RNAs) through the action of the adenosine deaminase acting on RNA (ADAR) enzymes.
Silvestris D. A., Scopa C., Hanchi S., Locatelli F., Gallo A.   +4 more
semanticscholar   +6 more sources

Discriminative Prediction of A-To-I RNA Editing Events from DNA Sequence. [PDF]

PLoS ONE, 2016
RNA editing is a post-transcriptional alteration of RNA sequences that, via insertions, deletions or base substitutions, can affect protein structure as well as RNA and protein expression.
Jiangming Sun, Yang De Marinis, Peter Osmark, Pratibha Singh, Annika Bagge, Bérengère Valtat, Petter Vikman, Peter Spégel, Hindrik Mulder   +8 more
doaj   +3 more sources

A-to-I RNA Editing and Human Disease [PDF]

RNA Biology, 2006
The post-transcriptional modification of mammalian transcripts by A-to-I RNA editing has been recognized as an important mechanism for the generation of molecular diversity and also regulates protein function through recoding of genomic information.
Stefan, Maas, Yukio, Kawahara, Kristen M, Tamburro, Kazuko, Nishikura   +3 more
openaire   +3 more sources

The evolution and adaptation of A-to-I RNA editing

PLOS Genetics, 2017
Adenosine-to-inosine (A-to-I) RNA editing is an important post-transcriptional modification that affects the information encoded from DNA to RNA to protein. RNA editing can generate a multitude of transcript isoforms and can potentially be used to optimize protein function in response to varying conditions.
Arielle L. Yablonovitch, Patricia Deng, Dionna Jacobson, Jin Billy Li   +3 more
openaire   +5 more sources

Substitutional A‐to‐I RNA editing [PDF]

WIREs RNA, 2010
AbstractAdenosine‐to‐inosine (A‐to‐I) editing catalyzed by adenosine deaminases acting on RNA (ADARs) entails the chemical conversion of adenosine residues to inosine residues within double‐stranded RNA (dsRNA) substrates. Inosine base pairs as guanosine and A‐to‐I editing can therefore alter the structure and base pairing properties of the RNA ...
Bjorn-Erik, Wulff, Kazuko, Nishikura
openaire   +3 more sources

The majority of A-to-I RNA editing is not required for mammalian homeostasis

Genome Biology, 2019
Background Adenosine-to-inosine (A-to-I) RNA editing, mediated by ADAR1 and ADAR2, occurs at tens of thousands to millions of sites across mammalian transcriptomes.
Alistair M. Chalk, Scott Taylor, Jacki E. Heraud-Farlow, Carl R. Walkley   +3 more
doaj   +2 more sources

Adaptation of A-to-I RNA editing in Drosophila

PLOS Genetics, 2017
Adenosine-to-inosine (A-to-I) editing is hypothesized to facilitate adaptive evolution by expanding proteomic diversity through an epigenetic approach. However, it is challenging to provide evidences to support this hypothesis at the whole editome level.
Yuange Duan, Shengqian Dou, Shiqi Luo, Hong Zhang, Jian Lu   +4 more
openaire   +5 more sources

A-to-I RNA editing and hematopoiesis

Experimental Hematology
Adenosine-to-inosine (A-to-I) RNA editing plays essential roles in modulating normal development and homeostasis. This process is catalyzed by adenosine deaminase acting on RNA (ADAR) family proteins. The most well-understood biological processes modulated by A-to-I editing are innate immunity and neurological development, attributed to ADAR1 and ADAR2,
Zhen, Liang, Carl R, Walkley, Jacki E, Heraud-Farlow   +2 more
openaire   +3 more sources

Transcriptome-wide identification of A > I RNA editing sites by inosine specific cleavage. [PDF]

RNA: A publication of the RNA Society, 2013
Adenosine to inosine (A > I) RNA editing, which is catalyzed by the ADAR family of proteins, is one of the fundamental mechanisms by which transcriptomic diversity is generated.
Pierre B. Cattenoz, R. Taft, E. Westhof, J. Mattick   +3 more
semanticscholar   +2 more sources