Results 1 to 10 of about 2,394 (127)

ADAR2 Protein Is Associated with Overall Survival in GBM Patients and Its Decrease Triggers the Anchorage-Independent Cell Growth Signature

Biomolecules, 2022
Background: Epitranscriptomic mechanisms, such as A-to-I RNA editing mediated by ADAR deaminases, contribute to cancer heterogeneity and patients’ stratification.
Valeriana Cesarini, Maurizio Martini, Franco Locatelli   +2 more
exaly   +3 more sources

ADAR2 induces the differentiation of osteosarcoma cells by editing activity on IGFBP7: new implications for therapy [PDF]

Bone Research
Osteosarcoma is a highly malignant bone tumor which primarily affects the juvenile population and is characterized by high rate of recurrence and metastasis. RNA editing has emerged as a key process in cancer progression. Herein, we investigated the role
Michela Rossi, Federica Scotto di Carlo, Jacopo Di Gregorio, Sharon Russo, Laura Di Giuseppe, Giulia Battafarano, Sara Terreri, Olivia Pagliarosi, Domenico Alessandro Silvestris, Marco Corona, Adriano Barra, Marco Pezzullo, Cristiano De Stefanis, Simone Pelle, Pier Francesco Costici, Salvatore Minisola, Jessica Pepe, Franco Locatelli, Fernando Gianfrancesco, Angela Gallo, Andrea Del Fattore   +20 more
doaj   +2 more sources

Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9‐ADAR2 delivery to motor neurons

EMBO Molecular Medicine, 2013
Amyotrophic lateral sclerosis (ALS) is the most common adult‐onset motor neuron disease, and the lack of effective therapy results in inevitable death within a few years of onset.
Shoji Tsuji, Shin-ichi Muramatsu, Shin Kwak   +2 more
exaly   +2 more sources

The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer

Cell Reports, 2018
Summary: Most colorectal cancer (CRC)-related deaths are due to liver metastases. PKCζ is a tumor suppressor in CRC with reduced expression in metastasis.
Yuki Nakanishi, Javier Caceres, Miguel Reina-Campos   +2 more
exaly   +3 more sources

RNA modifications, alternative splicing and circular RNA landscape in the mouse brain: inosine and beyond [PDF]

Scientific Reports
RNA modifications in the brain can be essential for regulating the transcriptome and brain function. Our study unveils the landscape of different RNA modifications associated with splicing within the mouse brain.
Erika Larrea, Maitena Tellaetxe-Abete, Yan Peng, Yujie Zhang, Shuangshuang Feng, Kaidong Lu, Liang Xue, Taisuke Nakahama, Yukio Kawahara, Magdalena J. Koziol   +9 more
doaj   +2 more sources

Inhibiting ADAR1-Mediated Excessive Epigenetic A-to-I RNA Editing Improves the Immune Microenvironment and Increases Sensitivity to Immunotherapy in Lung Adenocarcinoma. [PDF]

MedComm (2020)
This study investigated the potential of inhibiting ADAR1 which catalyzed excessive A‐to‐I RNA editing as a therapeutic strategy to augment the effectiveness of immunotherapy in LUAD. Mouse models demonstrated that inhibiting ADAR1 in tumor cells significantly improved the immune microenvironment by increasing PD‐L1 expression and CD8+ T‐cell ...
Wang S, Zheng S, Liu C, Zhang C, Wang X, Wang Z, Wang Y, Feng X, Xue Q, Sun N, He J.   +10 more
europepmc   +2 more sources

ADAR2 deficiency ameliorates non-alcoholic fatty liver disease and muscle atrophy through modulating serum amyloid A1

Journal of Cachexia, Sarcopenia and Muscle
Background Non‐alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength, which is commonly ...
Tai-Hua Yang, Chien-Chin Chen, Yun-Wen Chen   +2 more
exaly   +2 more sources

Propofol and Glioblastoma Biology: A Narrative Review of Perioperative Clinical Evidence and PI3K/AKT-Wnt-miRNA, GABA-A, and Immune-Checkpoint Pathways. [PDF]

Biomed Res Int
Glioblastoma multiforme (GBM) is the most prevalent and aggressive primary brain tumor, with a median survival of approximately 15 months despite current multimodal therapies. Recent clinical observations have suggested that the intravenous anesthetic propofol may be used to examine whether anesthetic agents can affect glioblastoma behavior.
Imani M, Lotfi M, Shahcheraghi SH.
europepmc   +2 more sources

Effect of SNORD113-3/ADAR2 on glycolipid metabolism in glioblastoma via A-to-I editing of PHKA2 [PDF]

Cellular & Molecular Biology Letters
Background Glioblastoma multiforme (GBM) is a highly aggressive brain tumor, characterized by its poor prognosis. Glycolipid metabolism is strongly associated with GBM development and malignant behavior.
Zheng Cui, Xiaobai Liu, Tiange E, Hongda Lin, Di Wang, Yunhui Liu, Xuelei Ruan, Ping Wang, Libo Liu, Yixue Xue   +9 more
doaj   +2 more sources

TSniffer: unbiased de novo identification of RNA editing sites and quantification of editing activity in RNA-seq data [PDF]

Genome Biology
RNA editing by adenosine deaminases acting on RNA (ADARs) is an essential cellular process performed by three enzymes in mammals: ADAR1-p150, ADAR1-p110, and ADAR2, demonstrating different target specificity and selectivity.
Maike Herrmann, Yvonne Krebs, Francisco M. Acosta, Sebastian Parusel, Oliver Siering, Felix G. M. Andres, Biruhalem Taye, Csaba Miskey, Christian K. Pfaller   +8 more
doaj   +2 more sources