Results 1 to 10 of about 4,102 (209)

Dissecting the basis for differential substrate specificity of ADAR1 and ADAR2

Nature Communications, 2023
Millions of adenosines are deaminated throughout the transcriptome by ADAR1 and/or ADAR2 at varying levels, raising the question of what are the determinants guiding substrate specificity and how these differ between the two enzymes.
Monika Witzenberger, Erez Y Levanon, Schraga Schwartz   +2 more
exaly   +4 more sources

Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method [PDF]

Nucleic Acids Research, 2016
Adenosine deamination is one of the most prevalent post-transcriptional modifications in mRNA. In humans, ADAR1 and ADAR2 catalyze this modification and their malfunction correlates with disease. Recently our laboratory reported crystal structures of the
Yuru Wang, Peter A Beal
exaly   +8 more sources

Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma [PDF]

Genome Biology, 2015
Background: ADAR enzymes convert adenosines to inosines within double-stranded RNAs, including microRNA (miRNA) precursors, with important consequences on miRNA retargeting and expression.
Shahar Alon, Silvia Galardi, Vinicia Assunta Polito   +2 more
exaly   +9 more sources

ADAR2 Protein Is Associated with Overall Survival in GBM Patients and Its Decrease Triggers the Anchorage-Independent Cell Growth Signature

Biomolecules, 2022
Background: Epitranscriptomic mechanisms, such as A-to-I RNA editing mediated by ADAR deaminases, contribute to cancer heterogeneity and patients’ stratification.
Valeriana Vc Cesarini, Domenico Alessandro Silvestris, Valentina Vt Tassinari   +2 more
exaly   +3 more sources

ADAR2 induces the differentiation of osteosarcoma cells by editing activity on IGFBP7: new implications for therapy. [PDF]

Bone Res
Osteosarcoma is a highly malignant bone tumor which primarily affects the juvenile population and is characterized by high rate of recurrence and metastasis. RNA editing has emerged as a key process in cancer progression. Herein, we investigated the role
Rossi M, Scotto di Carlo F, Di Gregorio J, Russo S, Di Giuseppe L, Battafarano G, Terreri S, Pagliarosi O, Silvestris DA, Corona M, Barra A, Pezzullo M, De Stefanis C, Pelle S, Costici PF, Minisola S, Pepe J, Locatelli F, Gianfrancesco F, Gallo A, Del Fattore A.   +20 more
europepmc   +2 more sources

ADAR2-dependent RNA editing of GluR2 is involved in thiamine deficiency-induced alteration of calcium dynamics [PDF]

Molecular Neurodegeneration, 2010
Background Thiamine (vitamin B1) deficiency (TD) causes mild impairment of oxidative metabolism and region-selective neuronal loss in the central nervous system (CNS). TD in animals has been used to model aging-associated neurodegeneration in
Chun Feng, Guang Yang, Jia Luo, Jing Xu, Liyun Zhao, Shuchen Lee, Xiaomin Zhang, Yanjie Wan, Ying Liu, Yong Liu, Yue Yong, Zhiqin Fan, Zun-Ji Ke   +12 more
core   +5 more sources

The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer

Cell Reports, 2018
Summary: Most colorectal cancer (CRC)-related deaths are due to liver metastases. PKCζ is a tumor suppressor in CRC with reduced expression in metastasis.
Angeles Duran, Yuki Nakanishi, Miguel Reina-Campos   +2 more
exaly   +3 more sources

RNA modifications, alternative splicing and circular RNA landscape in the mouse brain: inosine and beyond. [PDF]

Sci Rep
RNA modifications in the brain can be essential for regulating the transcriptome and brain function. Our study unveils the landscape of different RNA modifications associated with splicing within the mouse brain.
Larrea E, Tellaetxe-Abete M, Peng Y, Zhang Y, Feng S, Lu K, Xue L, Nakahama T, Kawahara Y, Koziol MJ.   +9 more
europepmc   +2 more sources

Effect of SNORD113-3/ADAR2 on glycolipid metabolism in glioblastoma via A-to-I editing of PHKA2. [PDF]

Cell Mol Biol Lett
Background Glioblastoma multiforme (GBM) is a highly aggressive brain tumor, characterized by its poor prognosis. Glycolipid metabolism is strongly associated with GBM development and malignant behavior.
Cui Z, Liu X, E T, Lin H, Wang D, Liu Y, Ruan X, Wang P, Liu L, Xue Y.   +9 more
europepmc   +2 more sources

ADAR2 deficiency ameliorates non‐alcoholic fatty liver disease and muscle atrophy through modulating serum amyloid A1

Journal of Cachexia, Sarcopenia and Muscle
Background Non‐alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength, which is commonly ...
Tai-Hua Yang, Yun-Wen Chen
exaly   +2 more sources