Novel exon of mammalian ADAR2 extends open reading frame.
PLoS ONE, 2009 BackgroundThe post-transcriptional processing of pre-mRNAs by RNA editing contributes significantly to the complexity of the mammalian transcriptome. RNA editing by site-selective A-to-I modification also regulates protein function through recoding of ...
Stefan Maas, Willemijn M Gommans
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When does ALS start? ADAR2-GluA2 hypothesis for the etiology of sporadic ALS [PDF]
Frontiers in Molecular Neuroscience, 2011 Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease. More than 90% of ALS cases are sporadic, and the majority of sporadic ALS patients do not carry mutations in genes causative of familial ALS; therefore ...
Takuto eHideyama +3 more
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TSniffer: unbiased de novo identification of RNA editing sites and quantification of editing activity in RNA-seq data. [PDF]
Genome BiolRNA editing by adenosine deaminases acting on RNA (ADARs) is an essential cellular process performed by three enzymes in mammals: ADAR1-p150, ADAR1-p110, and ADAR2, demonstrating different target specificity and selectivity.
Herrmann M +8 more
europepmc +2 more sources
Inhibiting ADAR1-Mediated Excessive Epigenetic A-to-I RNA Editing Improves the Immune Microenvironment and Increases Sensitivity to Immunotherapy in Lung Adenocarcinoma. [PDF]
MedComm (2020)This study investigated the potential of inhibiting ADAR1 which catalyzed excessive A‐to‐I RNA editing as a therapeutic strategy to augment the effectiveness of immunotherapy in LUAD. Mouse models demonstrated that inhibiting ADAR1 in tumor cells significantly improved the immune microenvironment by increasing PD‐L1 expression and CD8+ T‐cell ...
Wang S +10 more
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The RNA editing enzyme ADAR2 restricts L1 mobility [PDF]
RNA Biology, 2021 Adenosine deaminases acting on RNA (ADARs) are enzymes that convert adenosines to inosines in double-stranded RNAs (RNA editing A-to-I). ADAR1 and ADAR2 were previously reported as HIV-1 proviral factors. The aim of this study was to investigate the composition of the ADAR2 ribonucleoprotein complex during HIV-1 expression. By using a dual-tag affinity
Frassinelli L. +8 more
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c-Jun amino-terminal kinase-1 mediates glucose-responsive upregulation of the RNA editing enzyme ADAR2 in pancreatic beta-cells. [PDF]
PLoS ONE, 2012 A-to-I RNA editing catalyzed by the two main members of the adenosine deaminase acting on RNA (ADAR) family, ADAR1 and ADAR2, represents a RNA-based recoding mechanism implicated in a variety of cellular processes.
Liu Yang +9 more
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ADAR2-dependent GluA2 editing regulates cocaine seeking [PDF]
Molecular Psychiatry, 2014 Activation of AMPA receptors (AMPARs) in the nucleus accumbens is necessary for the reinstatement of cocaine-seeking behavior, an animal model of drug craving and relapse. AMPARs are tetrameric protein complexes that consist of GluA1-4 subunits, of which GluA2 imparts calcium permeability. Adenosine deaminase acting on RNA 2 (ADAR2) is a nuclear enzyme
Schmidt, H.D. +7 more
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Substrate recognition by ADAR1 and ADAR2 [PDF]
RNA, 2001 RNA editing catalyzed by ADAR1 and ADAR2 involves the site-specific conversion of adenosine to inosine within imperfectly duplexed RNA. ADAR1- and ADAR2-mediated editing occurs within transcripts of glutamate receptors (GluR) in the brain and in hepatitis delta virus (HDV) RNA in the liver.
S K, Wong, S, Sato, D W, Lazinski
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Computer-Aided Discovery of Natural Compounds Targeting the ADAR2 dsRBD2-RNA Interface and Computational Modeling of Full-Length ADAR2 Protein Structure. [PDF]
Int J Mol SciMesothelioma is a rare and aggressive cancer linked to asbestos exposure and characterized by rapid metastasis and poor prognosis. Inhibition of adenosine deaminase acting on dsRNA 2 (ADAR2) RNA binding but not ADAR2 editing has shown antitumor effects in mesothelioma.
Ashley CN +5 more
europepmc +3 more sources