c-Jun amino-terminal kinase-1 mediates glucose-responsive upregulation of the RNA editing enzyme ADAR2 in pancreatic beta-cells. [PDF]
PLoS ONE, 2012 A-to-I RNA editing catalyzed by the two main members of the adenosine deaminase acting on RNA (ADAR) family, ADAR1 and ADAR2, represents a RNA-based recoding mechanism implicated in a variety of cellular processes.
Liu Yang +9 more
doaj +2 more sources
Novel exon of mammalian ADAR2 extends open reading frame.
PLoS ONE, 2009 BackgroundThe post-transcriptional processing of pre-mRNAs by RNA editing contributes significantly to the complexity of the mammalian transcriptome. RNA editing by site-selective A-to-I modification also regulates protein function through recoding of ...
Stefan Maas, Willemijn M Gommans
doaj +2 more sources
When does ALS start? ADAR2-GluA2 hypothesis for the etiology of sporadic ALS [PDF]
Frontiers in Molecular Neuroscience, 2011 Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease. More than 90% of ALS cases are sporadic, and the majority of sporadic ALS patients do not carry mutations in genes causative of familial ALS; therefore ...
Takuto eHideyama +3 more
doaj +2 more sources
Communications BiologyNon-alcoholic fatty liver disease (NAFLD) is a chronic disease caused by hepatic steatosis. Adenosine deaminases acting on RNA (ADARs) catalyze adenosine to inosine RNA editing. However, the functional role of ADAR2 in NAFLD is unclear.
Mei-Lang Kung +7 more
doaj +2 more sources
ADAR2-dependent RNA editing of GluR2 is involved in thiamine deficiency-induced alteration of calcium dynamics [PDF]
Molecular Neurodegeneration, 2010 Background Thiamine (vitamin B1) deficiency (TD) causes mild impairment of oxidative metabolism and region-selective neuronal loss in the central nervous system (CNS).
Liu Yong +12 more
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Zebrafish Adar2 Edits the Q/R site of AMPA receptor Subunit gria2Ī± transcript to ensure normal development of nervous system and cranial neural crest cells. [PDF]
PLoS ONE, 2014 BackgroundAdar2 deaminates selective adenosines to inosines (A-to-I RNA editing) in the double-stranded region of nuclear transcripts. Although the functions of mouse Adar2 and its biologically most important substrate gria2, encoding the GluA2 subunit ...
I-Chen Li +10 more
doaj +1 more source
Co-occurrence of TDP-43 mislocalization with reduced activity of an RNA editing enzyme, ADAR2, in aged mouse motor neurons. [PDF]
PLoS ONE, 2012 TDP-43 pathology in spinal motor neurons is a neuropathological hallmark of sporadic amyotrophic lateral sclerosis (ALS) and has recently been shown to be closely associated with the downregulation of an RNA editing enzyme called adenosine deaminase ...
Takuto Hideyama +4 more
doaj +1 more source
ADAR2 increases in exercised heart and protects against myocardial infarction and doxorubicin-induced cardiotoxicity [PDF]
, 2021 Exercise training benefits the heart. The knowledge of post-transcription regulation, especially RNA editing, in hearts remain rare. ADAR2 is an enzyme that edits adenosine to inosine nucleotides in double-stranded RNA, and RNA editing isĀ associated with
Xiao, Junjie +11 more
core +1 more source
ADAR2-Dependent RNA Editing of AMPA Receptor Subunit GluR2 Determines Vulnerability of Neurons in Forebrain Ischemia [PDF]
, 2006 SummaryADAR2 is a nuclear enzyme essential for GluR2 pre-mRNA editing at Q/R site-607, which gates Ca2+ entry through AMPA receptor channels. Here, we show that forebrain ischemia in adult rats selectively reduces expression of ADAR2 enzyme and, hence ...
Zhu, Dongya +9 more
core +3 more sources
Dissecting the basis for differential substrate specificity of ADAR1 and ADAR2
Nature Communications, 2023 Millions of adenosines are deaminated throughout the transcriptome by ADAR1 and/or ADAR2 at varying levels, raising the question of what are the determinants guiding substrate specificity and how these differ between the two enzymes.
Marlon S. Zambrano-Mila +7 more
doaj +1 more source