Results 21 to 30 of about 4,102 (209)
Altered RNA Editing in Mice Lacking ADAR2 Autoregulation [PDF]
Molecular and Cellular Biology, 2006 ADAR2 is a double-stranded-RNA-specific adenosine deaminase involved in the editing of mammalian RNAs by the site-selective conversion of adenosine to inosine. Previous studies from our laboratory have demonstrated that ADAR2 can modify its own pre-mRNA to create a proximal 3' splice site containing a noncanonical adenosine-inosine dinucleotide ...
Yi, Feng +3 more
openaire +2 more sources
Zebrafish Adar2 Edits the Q/R site of AMPA receptor Subunit gria2α transcript to ensure normal development of nervous system and cranial neural crest cells. [PDF]
PLoS ONE, 2014 BackgroundAdar2 deaminates selective adenosines to inosines (A-to-I RNA editing) in the double-stranded region of nuclear transcripts. Although the functions of mouse Adar2 and its biologically most important substrate gria2, encoding the GluA2 subunit ...
I-Chen Li +10 more
doaj +1 more source
Co-occurrence of TDP-43 mislocalization with reduced activity of an RNA editing enzyme, ADAR2, in aged mouse motor neurons. [PDF]
PLoS ONE, 2012 TDP-43 pathology in spinal motor neurons is a neuropathological hallmark of sporadic amyotrophic lateral sclerosis (ALS) and has recently been shown to be closely associated with the downregulation of an RNA editing enzyme called adenosine deaminase ...
Takuto Hideyama +4 more
doaj +1 more source
A novel RNA pentaloop fold involved in targeting ADAR2 [PDF]
RNA, 2005 Adenosine deaminases that act on RNA (ADARs) catalyze the site-specific conversion of adenosine to inosine in primary mRNA transcripts, thereby affecting coding potential of mature mRNAs. Structural determinants that define the adenosine moieties for specific ADARs-mediated deaminations are currently unknown.
Richard, Stefl, Frédéric H-T, Allain
openaire +2 more sources
ADAR2 enzymes: efficient site-specific RNA editors with gene therapy aspirations
RNA, 2022 The adenosine deaminase acting on RNA (ADAR) enzymes are essential for neuronal function and innate immune control. ADAR1 RNA editing prevents aberrant activation of antiviral dsRNA sensors through editing of long, double-stranded RNAs (dsRNAs). In this review, we focus on the ADAR2 proteins involved in the efficient, highly site-specific RNA editing ...
Khadija Hajji +5 more
openaire +2 more sources
Gene and RNA Editing: Revolutionary Approaches to Treating Diseases. [PDF]
MedComm (2020)The image illustrates gene editing technologies: DNA editing using CRISPR–Cas9 and RNA editing via Cas13d, with their clinical applications and ethical risks. DNA editing allows precise gene modifications for conditions like amyotrophic lateral sclerosis [ALS] and Huntington's disease, while RNA editing supports multiplexed modifications.
Li JM +6 more
europepmc +2 more sources
ADAR1 and ADAR2 Expression and Editing Activity during Forebrain Development [PDF]
Developmental Neuroscience, 2009 The conversion of adenosine to inosine within RNA transcripts is regulated by a family of double-stranded RNA-specific adenosine deaminases referred to as adenosine deaminases that act on RNA (ADARs). Little is known regarding the developmental expression of ADAR family members or the mechanisms responsible for the specific patterns of editing observed
Michelle M, Jacobs +3 more
openaire +2 more sources
Splicing variants of ADAR2 and ADAR2-mediated RNA editing in glioma
Oncology Letters, 2016 The roles of alternative splicing and RNA editing in gene regulation and transcriptome diversity are well documented. Adenosine deaminases acting on RNA (ADARs) are responsible for adenosine-to-inosine (A-to-I) editing and exemplify the complex association between RNA editing and alternative splicing.
Yao, Fu +4 more
openaire +3 more sources
ADAR2/miR-589-3p axis controls glioblastoma cell migration/invasion [PDF]
Nucleic Acids Research, 2017 Recent studies have reported the emerging role of microRNAs (miRNAs) in human cancers. We systematically characterized miRNA expression and editing in the human brain, which displays the highest number of A-to-I RNA editing sites among human tissues, and in de novo glioblastoma brain cancer.
Valeriana Cesarini +7 more
openaire +5 more sources
Library Screening Reveals Sequence Motifs That Enable ADAR2 Editing at Recalcitrant Sites
ACS Chemical Biology, 2023 Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosine in duplex RNA. The inosine product preferentially base pairs with cytidine resulting in an effective A-to-G edit in RNA. ADAR editing can result in a recoding event alongside other alterations to RNA function.
Casey S. Jacobsen +6 more
openaire +4 more sources