Results 21 to 30 of about 2,950 (156)
Down-regulation of the RNA editing enzyme ADAR2 contributes to RGC death in a mouse model of glaucoma. [PDF]
PLoS ONE, 2014 Glaucoma is a progressive neurodegenerative disease of retinal ganglion cells (RGCs) associated with characteristic axon degeneration in the optic nerve.
Ai Ling Wang, Reed C Carroll, Scott Nawy
doaj +1 more source
adar1 and adar2 are broadly expressed.
, 2022 (A) Expression patterns of adar1 and adar2 by WISH (n ≥ 4). Black arrowheads mark enriched expression in the cephalic ganglion. The neoblasts markers soxP-1 and soxP-2 are used to control for probe specificity. Scale bar = 500μm.
Dan Bar Yaacov (11965433)
core +1 more source
Nature Communications, 2020 Human RNA editing enzymes ADAR1 and ADAR2 are required for innate immune functions and neurological functions, respectively. Here, the authors show that Drosophila Adar has both innate immune and brain functions, despite being the homolog of mammalian ...
Patricia Deng +11 more
doaj +1 more source
eLife, 2022 Adenosine deaminases acting on RNA (ADARs) can be repurposed to enable programmable RNA editing, however their exogenous delivery leads to transcriptome-wide off-targeting, and additionally, enzymatic activity on certain RNA motifs, especially those ...
Dhruva Katrekar +5 more
doaj +1 more source
dsRADAR: Imaging and Detecting Cellular dsRNA by Repurposing RNA‐Binding Proteins
Angewandte Chemie, EarlyView.Double‐stranded RNA (dsRNA) plays an important role in the innate immune system, but can be misregulated in disease, leading to inflammation. Despite the importance of this motif, methods for detecting dsRNA remain limited. This work shows that ADAR3 can be repurposed to provide improved detection of dsRNA, which is demonstrated in the context of viral
Weina Cheng +7 more
wiley +2 more sources
Modulation of ADAR mRNA expression in patients with congenital heart defects.
PLoS ONE, 2019 Adenosine (A) to inosine (I) RNA editing is a hydrolytic deamination reaction catalyzed by the adenosine deaminase (ADAR) enzyme acting on double-stranded RNA.
Faiza Altaf +5 more
doaj +1 more source
Identification of novel deregulated RNA metabolism-related genes in non-small cell lung cancer. [PDF]
PLoS ONE, 2012 Lung cancer is a leading cause of cancer death worldwide. Several alterations in RNA metabolism have been found in lung cancer cells; this suggests that RNA metabolism-related molecules are involved in the development of this pathology. In this study, we
Iñaki Valles +8 more
doaj +1 more source
Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma [PDF]
, 2015 BackgroundADAR enzymes convert adenosines to inosines within dsRNAs including microRNA (miRNA) precursors, with important consequences on miRNA retargeting and expression. ADAR2 activity is impaired in glioblastoma and its rescue has anti-tumoral effects.
Polito, Assunta +43 more
core +3 more sources
Molecular Oncology, 2022 We previously observed increased levels of adenosine‐deaminase‐acting‐on‐dsRNA (Adar)‐dependent RNA editing during mesothelioma development in mice exposed to asbestos.
Ananya Hariharan +19 more
doaj +1 more source
What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs [PDF]
Open Biology, 2020 Adenosine-to-inosine (A-to-I) editing is a post-transcriptional modification of RNA which changes its sequence, coding potential and secondary structure.
Jacki E. Heraud-Farlow +1 more
doaj +1 more source