Results 41 to 50 of about 4,102 (209)
EMBO Molecular Medicine, 2013 Amyotrophic lateral sclerosis (ALS) is the most common adult‐onset motor neuron disease, and the lack of effective therapy results in inevitable death within a few years of onset.
Takenari Yamashita +6 more
doaj +1 more source
eLife, 2022 Adenosine deaminases acting on RNA (ADARs) can be repurposed to enable programmable RNA editing, however their exogenous delivery leads to transcriptome-wide off-targeting, and additionally, enzymatic activity on certain RNA motifs, especially those ...
Dhruva Katrekar +5 more
doaj +1 more source
Modulation of ADAR mRNA expression in patients with congenital heart defects.
PLoS ONE, 2019 Adenosine (A) to inosine (I) RNA editing is a hydrolytic deamination reaction catalyzed by the adenosine deaminase (ADAR) enzyme acting on double-stranded RNA.
Faiza Altaf +5 more
doaj +1 more source
Identification of novel deregulated RNA metabolism-related genes in non-small cell lung cancer. [PDF]
PLoS ONE, 2012 Lung cancer is a leading cause of cancer death worldwide. Several alterations in RNA metabolism have been found in lung cancer cells; this suggests that RNA metabolism-related molecules are involved in the development of this pathology. In this study, we
Iñaki Valles +8 more
doaj +1 more source
Abnormal expression of an ADAR2 alternative splicing variant in gliomas downregulates adenosine-to-inosine RNA editing [PDF]
, 2014 BACKGROUND: RNA editing is catalyzed by adenosine deaminases acting on RNA (ADARs). ADAR2 is the main enzyme responsible for recoding editing in humans. Adenosine-to-inosine (A-to-I) editing at the Q/R site is reported to be decreased in gliomas; however,
Bin Qi +11 more
core +1 more source
Nature Communications, 2020 Human RNA editing enzymes ADAR1 and ADAR2 are required for innate immune functions and neurological functions, respectively. Here, the authors show that Drosophila Adar has both innate immune and brain functions, despite being the homolog of mammalian ...
Patricia Deng +11 more
doaj +1 more source
Molecular Oncology, 2022 We previously observed increased levels of adenosine‐deaminase‐acting‐on‐dsRNA (Adar)‐dependent RNA editing during mesothelioma development in mice exposed to asbestos.
Ananya Hariharan +19 more
doaj +1 more source
RNA editing system: Balancing altruistic antiviral defense and fitness trade-offs in fungi. [PDF]
mLifemLife, Volume 4, Issue 6, Page 597-601, December 2025.
Du Y, Jiang D, Liu H.
europepmc +2 more sources
ADAR1 restricts LINE-1 retrotransposition [PDF]
, 2016 Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosines to inosines in double-stranded RNAs. ADAR1 was demonstrated to be functional on different viruses exerting either antiviral or proviral effects.
Antonioni, Ambra +9 more
core +2 more sources
What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs [PDF]
Open Biology, 2020 Adenosine-to-inosine (A-to-I) editing is a post-transcriptional modification of RNA which changes its sequence, coding potential and secondary structure.
Jacki E. Heraud-Farlow +1 more
doaj +1 more source