Results 41 to 50 of about 2,950 (156)
ADAR2 siRNA in primary retinal cell culture.
, 2014 (A) ADAR2 was consistently observed in Tuj1 positive RGCs in primary cell culture. (B) After 5 days of incubation with ADAR2 siRNA, ADAR2 expression was absent in RGCs. Red: ADAR2; Green: Tuj1; Blue: DAPI.
Reed C. Carroll (532273) +2 more
core +1 more source
Ethanol Preference and Drinking Behavior Are Controlled by RNA Editing in the Nucleus Accumbens
Frontiers in Behavioral Neuroscience, 2019 RNA editing plays critical roles in normal brain function, and alteration of its activity causes various disorders. We previously found that chronic consumption of ethanol was associated with increased levels of RNA editing of serotonin 2C receptor in ...
Takahira Shirahase +8 more
doaj +1 more source
Down-regulation of ADAR2 induce RNA editing.
, 2019 A, B. Bar plots showing the normalized gene expression of ADAR1, ADAR2 and ADAR3 in each cell line. C, D. Bar plots showing the number of genomic variants in ADAR2 (C) and exons of ADAR2 (D). E, F.
Yi Hu (58993) +9 more
core +1 more source
The majority of A-to-I RNA editing is not required for mammalian homeostasis
Genome Biology, 2019 Background Adenosine-to-inosine (A-to-I) RNA editing, mediated by ADAR1 and ADAR2, occurs at tens of thousands to millions of sites across mammalian transcriptomes.
Alistair M. Chalk +3 more
doaj +1 more source
Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies
Advanced Science, Volume 13, Issue 50, 7 September 2026.Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Adolfo Saiardi +5 more
wiley +1 more source
Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics
MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.The challenges of mRNA therapy and the application of artificial intelligence and gene editing in the field of mRNA drugs. ABSTRACT Artificial intelligence (AI) and gene editing are increasingly being applied to the design and evaluation of mRNA therapeutics.
Haixing Shi +11 more
wiley +1 more source
RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities
MedComm, Volume 7, Issue 9, September 2026.RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley +1 more source
FLNB editing and ADAR1 expression in ADAR2-KO mice.
, 2019 (A) Electropherogram showing a 24% decrease in editing in ADAR2-KO compared to WT mouse tissues. This indicated that FLNB is primarily edited at the Q/R site by ADAR2. (B) Expression analysis of FLNB.
Faiza Altaf (6650675) +5 more
core +1 more source
Adar2 restricts line1 retrotransposition
, 2019 Adenosine deaminases that act on RNA (ADARs) catalyse the hydrolytic deamination of Adenosine (A) to Inosine (I) within double-stranded RNA substrates. In mammals three ADAR enzymes are present: ADAR1, ADAR2 and ADAR3.
FRASSINELLI, LOREDANA
core +1 more source
iMetaOmics, Volume 3, Issue 2, June 2026.Integrating multiplexed immunofluorescence, animal models, and clinical samples, our single‐cell and spatial atlas maps tumor microenvironment evolution during bladder cancer (BCa) progression. We reveal that stemness‐associated tumor cells (SDC1+), POSTN+ myofibroblastic cancer‐associated fibroblasts (mCAFs), and immunosuppressive monocytic myeloid ...
Ting Liang +13 more
wiley +1 more source