Results 51 to 60 of about 4,102 (209)

Conservation of A-to-I RNA editing in bowhead whale and pig

PLoS ONE, 2021
RNA editing is a post-transcriptional process in which nucleotide changes are introduced into an RNA sequence, many of which can contribute to proteomic sequence variation.
Knud Larsen, Mads Peter Heide-Jørgensen
doaj   +3 more sources

RNA editing signature during myeloid leukemia cell differentiation [PDF]

, 2017
Adenosine deaminases acting on RNA (ADARs) are key proteins for hematopoietic stem cell self-renewal and for survival of differentiating progenitor cells. However, their specific role in myeloid cell maturation has been poorly investigated.
A Athanasiadis, A Gallo, AS Shifera, BE Wulff, BJ Liddicoat, BL Bass, C Cenci, C Sundstrom, C Trapnell, C Trapnell, D Laxminarayana, E Picardi, E Picardi, G Camilli, H Aberle, H Li, JB Patterson, JC Hartner, JH Bahn, JM Desterro, Justin M. Thomas, K Nishikura, L Bazak, L Chen, M D'Antonio, M Daigneault, M Higuchi, M Vogler, MA Zipeto, MA Zipeto, N Mannion, N Paz-Yaacov, Q Jiang, Q Wang, Q Wang, R Marcucci, R XuFeng, RA Steinman, RJ Orlowski, S Tomaselli, S Tomaselli, T Hwang, TD Wu, TR Dawson, W Slotkin, Y Li, Y Pinto, YJ Crow, YS Baek   +48 more
core   +2 more sources

ADAR2 editing activity in newly diagnosed versus relapsed pediatric high-grade astrocytomas [PDF]

BMC Cancer, 2013
Abstract Background High-grade (WHO grade III and IV) astrocytomas are aggressive malignant brain tumors affecting humans with a high risk of recurrence in both children and adults. To date, limited information is available on the genetic and molecular alterations important in the onset and progression of pediatric ...
Tomaselli, S, Galeano, F, Massimi, Luca, Di Rocco, Concezio, Lauriola, Libero, Mastronuzzi, Angela, Locatelli, F, Gallo, A.   +7 more
openaire   +4 more sources

Activity-regulated RNA editing in select neuronal subfields in hippocampus [PDF]

, 2012
RNA editing by adensosine deaminases is a widespread mechanism to alter genetic information in metazoa. In addition to modifications in non-coding regions, editing contributes to diversification of protein function, in analogy to alternative splicing ...
Ales Balik, Altschul, Andrew C. Penn, Aruscavage, Bass, Birney, Bratt, Brorson, Coleman, Coleman, Daniel, Darty, Dawson, de la Mata, Feldmeyer, Feng, Fisahn, Gahwiler, Gainey, Gallo, Ge, Goodman, Greger, Greger, Greger, Gurevich, Hamada, Hideyama, Hideyama, Higuchi, Higuchi, Hoopengardner, Hundley, Ingo H. Greger, Jepson, Katoh, Kent, Lee, Lein, Li, Liu, Lomeli, Maas, Marcucci, Palladino, Paul, Peng, Peng, Penn, Penn, Penn, Pozo, Rosenthal, Rueter, Ryman, Sanjana, Schoft, Seeburg, Seeburg, Sommer, Sommer, Stefl, Stefl, Tariq, Toth, Traynelis, Turrigiano, Turrigiano, Valente, Venkatesh, Wang, Witter, Xie, Zsofia Nemoda   +73 more
core   +1 more source

Functional analysis of ADARs in planarians supports a bilaterian ancestral role in suppressing double-stranded RNA-response.

PLoS Pathogens, 2022
ADARs (adenosine deaminases acting on RNA) are known for their adenosine-to-inosine RNA editing activity, and most recently, for their role in preventing aberrant dsRNA-response by activation of dsRNA sensors (i.e., RIG-I-like receptor homologs). However,
Dan Bar Yaacov
doaj   +1 more source

Suppression of RNA editing by miR-17 inhibits the stemness of melanoma stem cells

Molecular Therapy: Nucleic Acids, 2022
More and more evidence suggests that microRNA (miRNA) and RNA editing play key roles in the development and progression of tumor. However, the influence of miRNA-mediated RNA editing on tumor stem cells remains unclear.
Yu Zhang, Xiaoyuan Yang, Yalei Cui, Xiaobo Zhang   +3 more
doaj   +1 more source

Solution structure of the N-terminal dsRBD of Drosophila ADAR and interaction studies with RNA [PDF]

, 2012
Adenosine deaminases that act on RNA (ADAR) catalyze adenosine to inosine (A-to-I) editing in double-stranded RNA (dsRNA) substrates. Inosine is read as guanosine by the translation machinery; therefore A-to-I editing events in coding sequences may ...
Barraud, Barraud, Barraud, Bass, Bhalla, Blaszczyk, Bratt, Bret S.E. Heale, Brunger, Brunger, Burns, Bycroft, Chang, Cho, DeLano, Dominguez, Duss, Eggington, Fierro-Monti, Frédéric H.-T. Allain, Gallo, Gan, Goddard, Graveley, Guntert, Guntert, Herrmann, Herrmann, Higuchi, Hood, Hoopengardner, Keegan, Keegan, Kharrat, Krovat, Laskowski, Lehmann, Leulliot, Lomeli, Maas, Macbeth, Mary A. O’Connell, Nishikura, Palladino, Palladino, Paro, Pierre Barraud, Ramos, Ryter, Saunders, Sommer, Stapleton, Stefl, Stefl, Stefl, Stephens, Valente, Wang, Wu, Yang   +59 more
core   +4 more sources

ADAR2-mediated editing of miR-214 and miR-122 precursor and antisense RNA transcripts in liver cancers. [PDF]

PLoS ONE, 2013
A growing list of microRNAs (miRNAs) show aberrant expression patterns in hepatocellular carcinoma (HCC), but the regulatory mechanisms largely remain unclear.
Wan-Hsin Liu, Chao-Hung Chen, Kun-Huei Yeh, Chiao-Ling Li, Yi-Jinn Wu, Ding-Shinn Chen, Pei-Jer Chen, Shiou-Hwei Yeh   +7 more
doaj   +1 more source

The Nefarious Nexus of Noncoding RNAs in Cancer [PDF]

, 2018
The past decade has witnessed enormous progress, which has seen the noncoding RNAs (ncRNAs) turn from the so called dark matter RNA to critical functional molecules, influencing most physiological processes in development and disease contexts.
Anastasiadou, Eleni, Faggioni, Alberto, J Slack, Frank, Trivedi, Pankaj   +3 more
core   +1 more source

Novel Etiological and Therapeutic Strategies for Neurodiseases: RNA Editing Enzyme Abnormality in Sporadic Amyotrophic Lateral Sclerosis

Journal of Pharmacological Sciences, 2010
The motor neurons of patients with sporadic amyotrophic lateral sclerosis (ALS) express abundant Q/R site–unedited GluR2 mRNA, whereas those of patients with other motor neuron diseases including familial ALS associated with mutated SOD1 (ALS1) and those
Takuto Hideyama, Takenari Yamashita, Yoshinori Nishimoto, Takeshi Suzuki, Shin Kwak   +4 more
doaj   +1 more source