Results 71 to 80 of about 2,950 (156)

Nucleic Acids Research / ADAR2 regulates RNA stability by modifying access of decay-promoting RNA-binding proteins

, 2017
Adenosine deaminases acting on RNA (ADARs) catalyze the editing of adenosine residues to inosine (A-to-I) within RNA sequences, mostly in the introns and UTRs (un-translated regions). The significance of editing within non-coding regions of RNA is poorly
Tripathi, Vidisha, Guang, Shuomeng, Gholamalamdari, Omid, Anantharaman, Aparna, Ma, Jian, Gorospe, Myriam, Prasanth, Kannanganattu V., Ohlson, Johan, Yoon, Je-Hyun, Öhman, Marie, Wahlstedt, Helene, Prasanth, Supriya G., Singh, Deepak K., Conrad, Nicholas K., Khan, Abid, Jantsch, Franz-Michael   +15 more
core   +1 more source

A-to-I editing in human miRNAs is enriched in seed sequence, influenced by sequence contexts and significantly hypoedited in glioblastoma multiforme

Scientific Reports, 2017
Editing in microRNAs, particularly in seed can significantly alter the choice of their target genes. We show that out of 13 different human tissues, different regions of brain showed higher adenosine to inosine (A-to-I) editing in mature miRNAs.
Deepanjan Paul, Ashis Narayan Sinha, Arjun Ray, Megha Lal, Subhashree Nayak, Anchal Sharma, Bharati Mehani, Debasish Mukherjee, Saurabh V. Laddha, Ashish Suri, Chitra Sarkar, Arijit Mukhopadhyay   +11 more
doaj   +1 more source

Core-binding factor fusion downregulation of ADAR2 RNA editing contributes to AML leukemogenesis

, 2023
Adenosine-to-inosine RNA editing, which is catalyzed by adenosine deaminases acting on RNA (ADAR) family of enzymes, ADAR1 and ADAR2, has been shown to contribute to multiple cancers.
Jen, Wei Ying, Pulikkan, John Anto, Guo, Mingrui, Tan, Lip Kun, Tan, Zhi Qing, Ooi, Melissa G. M., Ng, Vanessa Hui En, Fullwood, Melissa Jane, Peramangalam, Philomina Sona, Song, Yangyang, Cao, Xinang, Matsuoka, Masao, Wang, Wilson, Chun, Chan Ming, Chng, Wee Joo, Yang, Henry, Koh, Liang Piu, Tan, Zi Hui, Iwanaga, Eisaku, Chan, Tim Hon Man, Koh, Bryan T. H., Osato, Motomi, Goh, Yufen, Li, Ying, Chan, Esther, Chen, Leilei, Tenen, Daniel G., An, Omer, Zhou, Qiling   +28 more
core   +1 more source

Genome-wide analysis of consistently RNA edited sites in human blood reveals interactions with mRNA processing genes and suggests correlations with cell types and biological variables

BMC Genomics, 2018
Background A-to-I RNA editing is a co−/post-transcriptional modification catalyzed by ADAR enzymes, that deaminates Adenosines (A) into Inosines (I).
Edoardo Giacopuzzi, Massimo Gennarelli, Chiara Sacco, Alice Filippini, Jessica Mingardi, Chiara Magri, Alessandro Barbon   +6 more
doaj   +1 more source

Molecular mechanisms of ADAR2 localization and substrate specificity

, 2006
ADAR2-mediated adenosine-to-inosine (A-to-I) RNA editing can affect the coding potential, splicing pattern, stability, and localization of the targeted RNA transcripts.
Xu, Ming
core  

胶质瘤中RNA编辑酶ADAR2,ADAR3 mRNA表达及意义

Zhongguo shiyan zhenduanxue, 2006
目的观察不同恶性程度的胶质瘤细胞中RNA编辑酶ADAR2（RED1）,ADAR3（RED2）mRNA水平的表达。方法对原代培养的正常人脑胶质细胞和胶质瘤细胞SHG-44,U-251,BT-325,应用ADAR2,ADAR3全长序列合成引物及合成的特异引物,用逆转录PCR及图像分析法检测ADAR2,ADAR3 mRNA水平的表达。ADAR基因表达水平用基因/β-肌动蛋白（-βactin）灰度比值表示。结果ADAR2在正常人脑胶质细胞中表达极弱,在低恶性度的胶质瘤SHG-44细胞中呈弱表达 ...
田宇, 潘玉琢, 杜超, 高俊, 李桂林, 李桂英, 王任直   +6 more
doaj  

A survey on cellular RNA editing activity in response to Candida albicans infections

BMC Genomics, 2018
Background Adenosine-to-Inosine (A-to-I) RNA editing is catalyzed by the adenosine deaminase acting on RNA (ADAR) family of enzymes, which induces alterations in mRNA sequence.
Yaowei Huang, Yingying Cao, Jiarui Li, Yuanhua Liu, Wu Zhong, Xuan Li, Chen Chen, Pei Hao   +7 more
doaj   +1 more source

GluA2 is rapidly edited at the Q/R site during neural differentiation in vitro

Frontiers in Cellular Neuroscience, 2015
The majority of AMPA receptors in the adult brain contain GluA2 subunits, which can be edited at the Q/R site, changing a glutamine to an arginine within the ion pore.
Svenja ePachernegg, Svenja ePachernegg, Svenja ePachernegg, Yvonne eMünster, Elke eMuth-Koehne, Elke eMuth-Koehne, Elke eMuth-Koehne, Elke eMuth-Koehne, Gloria eFuhrmann, Gloria eFuhrmann, Michael eHollmann   +10 more
doaj   +1 more source

RNA editing system: Balancing altruistic antiviral defense and fitness trade‐offs in fungi

mLife, Volume 4, Issue 6, Page 597-601, December 2025.
Yanfei Du, Daohong Jiang, Huiquan Liu
wiley   +1 more source

Knockdown of ADAR2 increases rectification of AMPAR currents.

, 2014
(A) Representative traces from an RGC transfected with ADAR2 SiRNA (Ai) and another transfected with scrambled SiRNA (Aii). Both cells were recorded from with a pipet solution containing 300 µM spermine, which blocks CP-AMPAR currents at positive, but ...
Reed C. Carroll (532273), Ai Ling Wang (90011), Scott Nawy (389553)   +2 more
core   +1 more source