Results 81 to 90 of about 2,950 (156)
ADAR2 mediated Q/R editing of GluK2 regulates homeostatic plasticity of kainate receptors
, 2018 Kainate receptors (KARs) are heteromeric glutamate-gated ion channels that regulate neuronal excitability and network function in the brain. Most KARs contain the subunit GluK2 and the precise properties of these GluK2-containing KARs are determined by ...
Kevin A. Wilkinson +3 more
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Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method [PDF]
, 2016 Adenosine deamination is one of the most prevalent post-transcriptional modifications in mRNA. In humans, ADAR1 and ADAR2 catalyze this modification and their malfunction correlates with disease. Recently our laboratory reported crystal structures of the
Beal, Peter A, Wang, Yuru
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ADAR2 was decreased in retina in a glaucoma model with chronic elevated IOP.
, 2014 (A) In the control mouse retina, nuclear localization of ADAR2 was observed in Tuj1 positive cells. (B) In the retina of the glaucoma model, ADAR2 expression was decreased. Red: ADAR2; Tuj1: green; DAPI: blue.
Reed C. Carroll (532273) +2 more
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RNA-Seq Analysis Identifies a Novel Set of Editing Substrates for Human ADAR2 Present in Saccharomyces cerevisiae [PDF]
, 2013 ADAR2 is a member of a family of RNA editing enzymes found in metazoa that bind double helical RNAs and deaminate select adenosines. We find that when human ADAR2 is overexpressed in the budding yeast Saccharomyces cerevisiae it substantially reduces the
Pokharel, Subhash +2 more
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, 2016 ADAR2 is a member of a family of RNA editing enzymes found in metazoa that bind double helical RNAs and deaminate select adenosines. We find that when human ADAR2 is overexpressed in the budding yeast Saccharomyces cerevisiae it substantially reduces the
Tristan Eifler (1886488) +2 more
core +1 more source
Zhongguo shiyan zhenduanxue, 2010 目的探讨RNA编辑酶在结直肠癌组织标本中的表达及其意义。方法收集临床结直肠癌组织标本及癌周正常组织标本12例,应用RT-PCR法检测RNA编辑酶ADAR1、ADAR2在结直肠癌组织及癌旁正常组织标本中的表达并分析。结果编辑酶ADAR1在人结直肠癌组织及癌旁组织中未见明显表达,而编辑酶ADAR2在结直肠癌组织及结直肠癌旁组织中阳性表达,并在结直肠癌组织中表达增强（癌组织中阳性表达率为75%,癌旁组织阳性表达率为41.7 ...
张广 +4 more
doaj
, 2011 Adenosine deaminases acting on RNA (ADARs) catalyze the C-6 deamination of adenosine (A) to produce inosine (I), which behaves as guanine (G), thereby altering base pairing in RNAs with double-stranded character.
Cyril X. George, Charles E. Samuel
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Induced Loss of ADAR2 Engenders Slow Death of Motor Neurons from Q/R Site-Unedited GluR2
, 2010 GluR2 is a subunit of the AMPA receptor, and the adenosine for the Q/R site of its pre-mRNA is converted to inosine (A-to-I conversion) by the enzyme called adenosine deaminase acting on RNA 2 (ADAR2).
Ryosuke Takahashi +8 more
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Accumulation of nuclear ADAR2 regulates A-to-I RNA editing during neuronal development
, 2017 Adenosine to inosine (A-to-I) RNA editing is important for a functional brain, and most known sites that are subject to selective RNA editing have been found to result in diversified protein isoforms that are involved in neurotransmission. In the absence
Eriksson, Maria +9 more
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SRSF9 selectively represses ADAR2-mediated editing of brain-specific sites in primates
, 2018 Adenosine-to-inosine (A-to-I) RNA editing displays diverse spatial patterns across different tissues. However, the human genome encodes only two catalytically active editing enzymes (ADAR1 and ADAR2), suggesting that other regulatory factors help shape ...
Zhang, Xiujun +10 more
core +1 more source