Results 81 to 90 of about 4,102 (209)
Substrate-dependent Contribution of Double-stranded RNA-binding Motifs to ADAR2 Function [PDF]
Molecular Biology of the Cell, 2006 ADAR2 is a double-stranded RNA-specific adenosine deaminase involved in the editing of mammalian RNAs by the site-specific conversion of adenosine to inosine (A-to-I). ADAR2 contains two tandem double-stranded RNA-binding motifs (dsRBMs) that are not only important for efficient editing of RNA substrates but also necessary for localizing ADAR2 to ...
Ming, Xu, K Sam, Wells, Ronald B, Emeson
openaire +2 more sources
In vivo RNA editing of point mutations via RNA-guided adenosine deaminases. [PDF]
, 2019 We present in vivo sequence-specific RNA base editing via adenosine deaminases acting on RNA (ADAR) enzymes with associated ADAR guide RNAs (adRNAs). To achieve this, we systematically engineered adRNAs to harness ADARs, and comprehensively evaluated the
Chen, Genghao +7 more
core +1 more source
Mutations underlying Episodic Ataxia type-1 antagonize Kv1.1 RNA editing [PDF]
, 2017 © The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Scientific Reports 7 (2017): 41095, doi:10.1038/srep41095.Adenosine-to-inosine RNA editing in ...
Ayers, Gregory D. +3 more
core +1 more source
Clinical and Translational Discovery, Volume 5, Issue 6, December 2025.Gastric precancerous lesions undergo dynamic epigenetic alterations—including DNA methylation, 5‐hydroxymethylcytosine, non‐coding RNAs, and RNA editing—throughout the Correa's cascade. The integration of these multi‐omics epigenetic signatures facilitates non‐invasive risk stratification, which guides personalised surveillance strategy and targeted ...
Kewei Ma +4 more
wiley +1 more source
A-to-I RNA editing enzyme ADAR2 regulates light-induced circadian phase-shift
Scientific Reports, 2018 In mammals, the central circadian clock is located in the suprachiasmatic nucleus (SCN) of the hypothalamus and it orchestrates peripheral clocks in the whole body to organize physiological and behavioral rhythms.
Hideki Terajima +4 more
doaj +1 more source
The contribution of Alu exons to the human proteome. [PDF]
, 2016 BackgroundAlu elements are major contributors to lineage-specific new exons in primate and human genomes. Recent studies indicate that some Alu exons have high transcript inclusion levels or tissue-specific splicing profiles, and may play important ...
Jiang, Peng +7 more
core +1 more source
PLoS Genetics, 2021 Adenosine deaminase acting on RNA 1 (ADAR1), an enzyme responsible for adenosine-to-inosine RNA editing, is composed of two isoforms: nuclear p110 and cytoplasmic p150.
Jung In Kim +11 more
doaj +1 more source
Advanced Science, Volume 12, Issue 42, November 13, 2025.This study reveals that ADAR1, an RNA‐editing enzyme, fine‐tunes immune responses in the placenta by preventing the accumulation of immunogenic double‐stranded RNAs (dsRNAs) from interferon‐stimulated genes. The loss of ADAR1 in the placenta leads to excessive interferon signaling restricted to the junctional zone, disrupting placental development and ...
Xiaogang Chen +7 more
wiley +1 more source
Assembly, Secretory Pathway Trafficking, and Surface Delivery of Kainate Receptors Is Regulated by Neuronal Activity [PDF]
, 2017 Summary: Ionotropic glutamate receptor (iGluR) trafficking and function underpin excitatory synaptic transmission and plasticity and shape neuronal networks.
Evans, Ashley J. +4 more
core +3 more sources
Engineered RNA Devices for In Vivo Targeted Therapeutics via Advanced Delivery Systems
Aggregate, Volume 6, Issue 11, November 2025.Schematic illustration of engineered RNA devices for in vivo targeted therapeutics via advanced delivery systems. ABSTRACT Engineered RNA devices can identify disease‐specific markers and precisely regulate gene expression, which is of great significance to the development of precision medicine.
Wei Luo +6 more
wiley +1 more source