Results 91 to 100 of about 2,950 (156)

Editing profile of OPHN1 in astrocytoma cell lines overexpressing ADAR2 or silenced for ADAR1.

, 2014
Editing analysis of OPHN1 pre-mRNA (AluJo, sites 1–14) in U118 and U87 astrocytoma cell lines overexpressing ADAR2 or silenced for ADAR1. The sites preferentially edited by a specific enzyme are indicated in bold and the sites edited by both ADARs are in
Ginevra Zanni (538001), Sara Tomaselli (139009), Franco Locatelli (130400), Alekos Athanasiadis (70850), Angela Gallo (139000), Sabina Barresi (538000), Enrico Bertini (156405), Federica Galeano (139004)   +7 more
core   +1 more source

ADAR mRNA在胰腺癌及癌旁组织中的表达及意义

Zhongguo shiyan zhenduanxue, 2011
研究发现RNA编辑酶（Adenosine Deaminases Acting on RNA,ADAR）在多种恶性肿瘤中表达异常,提示RNA编辑酶与恶性肿瘤的发生、发展可能相关。目前,国内外研究目标集中于ADAR1和ADAR2,它们在胰腺癌中的表达尚未明确。胰腺癌是我国最常见的恶性肿瘤之一,严重威胁着人类生命健康,本实验拟通过应用半定量RT ...
王岩, 陈丽波, 魏君, 姜涛
doaj  

The role of ADAR1 through and beyond its editing activity in cancer

Cell Communication and Signaling
Adenosine-to-inosine (A-to-I) editing of RNA, catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes, is a prevalent RNA modification in mammals.
Yue Jiao, Yuqin Xu, Chengbin Liu, Rui Miao, Chunyan Liu, Yilong Wang, Jiao Liu   +6 more
doaj   +1 more source

Interferons induce dendritic spine loss through ADAR2-mediated RNA-editing of the GluA2 Q/R site

Alzheimer's Disease (AD) is characterised by progressive inflammation, synaptic loss and neurodegeneration, processes that have been shown to be influenced by various factors including post-transcriptional modifications of RNA.
Milham, Luke
core   +1 more source

In vivo and in vitro studies on geniposide suppressing malignant progression of glioblastoma by enhancing miR-376b-3p A-to-I editing to inhibit glycolysis

Zhongguo aizheng zazhi
MethodsHigh-throughput sequencing was used to quantitatively analyze the editing levels of miR-376b-3p in cancer tissues and paired adjacent non-tumor tissues from 32 GBM patients treated at The First Affiliated Hospital of Nanyang Medical College from ...
WU Shuchao, WANG Bo, WEI Zhixuan, SONG Yu, CUI Qunjian, XIE Zongxin   +5 more
doaj  

ADAR1 and ADAR2 Expression in the Thoracic Aortic Wall Correlates with Aneurysm Severity and Dissection Risk: Insights into A-to-I RNA Editing Dysregulation in Marfan Syndrome-Derived vSMCs. [PDF]

Int J Mol Sci
Pisano C, Colopi A, Silvestris DA, Terriaca S, Guida E, Porreca A, Sbrigata A, Doronzio PN, Orlandi A, Dolci S, La Rosa P, Cesarini V.   +11 more
europepmc   +1 more source

ADAR-mediated RNA editing in CNS disorders: from pathogenic mechanisms to therapeutic opportunities. [PDF]

Cell Mol Biol Lett
Zheng F, Guan R, Yu X, Yang J, Zhao H, Yang F.   +5 more
europepmc   +1 more source

The effect of ADAR2 in osteosarcoma

Bone Reports, 2020
Michela Rossi, Viviana De Martino, Giulia Battafarano, Eda Mariani, Valeriana Cesarini, Salvatore Minisola, Angela Gallo, Andrea Del Fattore   +7 more
doaj   +1 more source

Distinguishing self from non-self RNA by editing-specific inosine patterns. [PDF]

Nucleic Acids Res
Varada R, Leuchtenberger AF, Vesely C, Kaczmarek B, Mansouri Khosravi H, Mandl TC, Milanovic K, Honarmand Tamizkar K, Rajendra V, Senoner H, Steinbichl L, Borojevic M, Sombke A, Schmidt K, Eckhard M, Hofacker IL, Walkley C, Heraud-Farlow JE, Picardi E, Bernecky C, Jantsch MF.   +20 more
europepmc   +1 more source

ADAR1 and ADAR2 associate with the RNA exosome and modulate RNA stability. [PDF]

Nucleic Acids Res
Vukić D, Du Q, Cherian A, Amoruso D, Brožinová K, Wacheul L, Lacovich V, Zorbas C, Yadav L, Sedmík J, Keskitalo S, Hajji K, Stejskal S, Varjosalo M, Lafontaine DLJ, Keegan LP, O'Connell MA.   +16 more
europepmc   +1 more source