Results 91 to 100 of about 4,102 (209)

ADAR2: Towards a Structural and Kinetic Understanding of RNA Editing [PDF]

Biophysical Journal, 2014
Adenosine Deaminases that Act on RNA (ADARs) are a small family of enzymes found in metazoans which edit pre-mRNAs by modifying the base adenosine to inosine. This editing results in translational mutations as inosine is interpreted as guanosine by translational machinery.
Kehr, Andrew D., Macbeth, Mark R., Rule, Gordon S.   +2 more
openaire   +1 more source

Transcriptome-wide identification of A > I RNA editing sites by inosine specific cleavage [PDF]

, 2013
Adenosine to inosine (A > I) RNA editing, which is catalyzed by the ADAR family of proteins, is one of the fundamental mechanisms by which transcriptomic diversity is generated.
Cattenoz, Pierre B., Mattick, John S., Taft, Ryan J., Westhof, Eric   +3 more
core   +2 more sources

New insights into applications of base editor in hereditary disorders

Interdisciplinary Medicine, Volume 3, Issue 6, November 2025.
Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai, Linhui Zhang, Liqing Li, Yue Liu, Canbin Lv, Yan Shi, Jianyuan Zhao, Dingwei Ye, Yuanyuan Qu   +8 more
wiley   +1 more source

Identification of evolutionarily meaningful information within the mammalian RNA editing landscape [PDF]

, 2014
A large comparative genomic sequence study has determined the extent of conservation between RNA editing sites within the mammalian evolutionary tree.
Robert A Reenan, Yiannis A Savva
core   +2 more sources

Metabolomic and Lipidomic Profiling Identifies The Role of the RNA Editing Pathway in Endometrial Carcinogenesis

Scientific Reports, 2017
Endometrial cancer (EC) remains the most common malignancy of the genital tract among women in developed countries. Although much research has been performed at genomic, transcriptomic and proteomic level, there is still a significant gap in the ...
Tatiana Altadill, Tyrone M. Dowdy, Kirandeep Gill, Armando Reques, Smrithi S. Menon, Cristian P. Moiola, Carlos Lopez-Gil, Eva Coll, Xavier Matias-Guiu, Silvia Cabrera, Angel Garcia, Jaume Reventos, Stephen W. Byers, Antonio Gil-Moreno, Amrita K. Cheema, Eva Colas   +15 more
doaj   +1 more source

Oligophrenin-1 (OPHN1), a gene involved in X-linked intellectual disability, undergoes RNA editing and alternative splicing during human brain development. [PDF]

PLoS ONE, 2014
Oligophrenin-1 (OPHN1) encodes for a Rho-GTPase-activating protein, important for dendritic morphogenesis and synaptic function. Mutations in this gene have been identified in patients with X-linked intellectual disability associated with cerebellar ...
Sabina Barresi, Sara Tomaselli, Alekos Athanasiadis, Federica Galeano, Franco Locatelli, Enrico Bertini, Ginevra Zanni, Angela Gallo   +7 more
doaj   +1 more source

Unveiling the Role of circRNAs in Pyroptotic Signalling: From Molecular Crosstalk to Disease Modulation

Journal of Cellular and Molecular Medicine, Volume 29, Issue 22, November 2025.
ABSTRACT Pyroptosis is a gasdermins‐dependent programmed cell death (PCD) characterised by progressive cellular swelling and plasma membrane rupture (PMR). This process releases intracellular contents that amplify inflammatory cascades and immune activation, involving the pathogenesis of various disorders such as tumours, heart and vascular diseases ...
Tengyu Jin, Guodong Xu, Wanru Zhou, Yige Shi, Hebo Wang   +4 more
wiley   +1 more source

Structure and Specific RNA Binding of ADAR2 Double-Stranded RNA Binding Motifs [PDF]

Structure, 2006
Adenosine deaminases that act on RNA (ADARs) site-selectively modify adenosines to inosines within RNA transcripts, thereby recoding genomic information. How ADARs select specific adenosine moieties for deamination is poorly understood. Here, we report NMR structures of the two double-stranded RNA binding motifs (dsRBMs) of rat ADAR2 and an NMR ...
Stefl, Richard, Xu, Ming, Skrisovska, Lenka, Emeson, Ronald B., Allain, Frédéric H.-T.   +4 more
openaire   +2 more sources

RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling [PDF]

, 2013
The Hedgehog (HH) signaling pathway has important roles in tumorigenesis and in embryonal patterning. The Gliomaassociated oncogene 1 (GLI1) is a key molecule in HH signaling, acting as a transcriptional effector and, moreover, is considered to be a ...
Mohammed Ferdous-Ur, Rahman, Palaniswamy, R., Pivarcsi, A., Shimokawa, T., Sonkoly, E., Ståhle, M., Tostar, U., Zaphiropoulos, P. G.   +7 more
core   +1 more source

Nomogram Based on A‐To‐I RNA Editing for Predicting Overall Survival in Patients With Breast Cancer

Journal of Cellular and Molecular Medicine, Volume 29, Issue 18, September 2025.
ABSTRACT Adenosine‐to‐inosine RNA editing (ATIRE) is the most common type of RNA editing in higher eukaryotes. Many RNA editing events are associated with the occurrence and development of various tumours. Currently, several ATIRE sites have been used as predictors of cancer prognosis.
Yangyang Zhang, Jia Zhou, Hong Li, Dahai Chai, Bin Lian, Yaobang Liu, Li Guo, Jinping Li   +7 more
wiley   +1 more source