Results 101 to 110 of about 4,102 (209)

Dimerization of ADAR2 is mediated by the double-stranded RNA binding domain [PDF]

RNA, 2006
Members of the family of adenosine deaminases acting on RNA (ADARs) can catalyze the hydrolytic deamination of adenosine to inosine and thereby change the sequence of specific mRNAs with highly double-stranded structures. The ADARs all contain one or more repeats of the double-stranded RNA binding motif (DRBM).
Poulsen, Hanne, Jorgensen, Rasmus, Heiding, Anders, Nielsen, Finn C., Bonven, Bjarne Juul, Jensen, Jan Egebjerg   +5 more
openaire   +3 more sources

Population and allelic variation of A-to-I RNA editing in human transcriptomes. [PDF]

, 2017
BackgroundA-to-I RNA editing is an important step in RNA processing in which specific adenosines in some RNA molecules are post-transcriptionally modified to inosines.
Demirdjian, Levon, Guo, Jiguang, Lin, Lan, Park, Eddie, Shen, Shihao, Wu, Ying Nian, Xing, Yi   +6 more
core   +2 more sources

Enhancing Specificity, Precision, Accessibility, Flexibility, and Safety to Overcome Traditional CRISPR/Cas Editing Challenges and Shape Future Innovations

Advanced Science, Volume 12, Issue 28, July 24, 2025.
CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi, Mohamed Ramadan, Lu Yu, Fengjiao Hui, Amjad Hussain, Xiaofeng Zhou, Yu Yu, Xianlong Zhang, Shuangxia Jin   +8 more
wiley   +1 more source

Current developments in gene therapy for amyotrophic lateral sclerosis. [PDF]

, 2015
INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a devastating adult neurodegenerative disorder characterized by motor neuron degeneration and death around 3 years from onset.
Alrafiah, A.R., Azzouz, M., Herranz-Martín, S., Scarrott, J.M., Shaw, P.J.   +4 more
core   +1 more source

PP2A Promotes the Symmetric Division of MUC1‐Dominant Cancer Stem‐Like Cells in Small Cell Lung Cancer

Advanced Science, Volume 12, Issue 25, July 3, 2025.
During the G2/M phase, mucin1 (MUC1) activates protein phosphatase 2A (PP2A), leading to reduced phosphorylation of protein kinase C ζ (PKCζ) and NUMB, which promotes symmetric division and expansion of cancer stem‐like cells (CSLCs), thereby driving tumorigenesis. Combined inhibition of the MUC1–PP2A axis using LB100/GO203 with etoposide restores PKCζ
Shengze Li, Xinran Dong, Kexing Gao, Yiyang Wang, Min Li, Huayun Deng, Shuangyu Ma, Yaping Lv, Wei Jin, Quanfu Li, Yuming Wang, Xiaodong Liao, Kangjing Bian, Aiwu Zhou, Chengping Hu, Lei Huang   +15 more
wiley   +1 more source

ADAR2 editing enzyme is a novel human immunodeficiency virus-1 proviral factor

Journal of General Virology, 2011
The adenosine deaminases acting on RNA (ADAR) enzymes catalyse conversion of adenosine to inosine in dsRNA. A positive effect of ADAR1 on human immunodeficiency virus type 1 (HIV-1) replication has recently been reported. Here, we show that another ADAR enzyme, ADAR2, positively affects the replication process of HIV-1.
Doria, M, Tomaselli, S, Neri, F, CIAFRE', SILVIA ANNA, FARACE, MARIA GIULIA, MICHIENZI, ALESSANDRO, Gallo, A.   +6 more
openaire   +4 more sources

RNA recognition by double-stranded RNA binding domains: a matter of shape and sequence [PDF]

, 2018
The double-stranded RNA binding domain (dsRBD) is a small protein domain of 65-70 amino acids adopting an αβββα fold, whose central property is to bind to double-stranded RNA (dsRNA).
Allain, Frédéric, Barraud, Pierre, Masliah, Grégoire   +2 more
core  

Evaluation of Engineered CRISPR-Cas-Mediated Systems for Site-Specific RNA Editing

Cell Reports, 2020
Summary: Site-directed RNA editing approaches offer great potential to correct genetic mutations in somatic cells while avoiding permanent off-target genomic edits.
Ryan J. Marina, Kristopher W. Brannan, Kevin D. Dong, Brian A. Yee, Gene W. Yeo   +4 more
doaj   +1 more source

Decoding RNA–Protein Interactions: Methodological Advances and Emerging Challenges

Advanced Genetics, Volume 6, Issue 2, June 2025.
This review provides a comprehensive comparison of RNA‐ and protein‐centric methodologies for investigating RNA–protein interactions, emphasizing their respective advantages, limitations, and suitable applications. It highlights recent technological innovations, outlines strategic method selection criteria, and addresses key challenges.
Wenkai Yi, Jian Yan
wiley   +1 more source

Enhancing RNA editing efficiency and specificity with engineered ADAR2 guide RNAs

Molecular Therapy Nucleic Acids
RNA editing is a prospective therapeutic approach for correcting harmful mutations, offering the benefits of reversibility and tunability without permanently modifying the genome. However, the relatively low enzymatic activity and the occurrence of off-target editing events present significant challenges, limiting its utility.
Xilei Ai, Sheng Ding, Shan Zhou, Feng Du, Shuai Liu, Xin Cui, Juan Dong, Xin Huang, Zhuo Tang   +8 more
openaire   +2 more sources