Results 21 to 30 of about 134,460,322 (302)

Knowledge in the Investigation of A-to-I RNA Editing Signals [PDF]

Frontiers in Bioengineering and Biotechnology, 2015
RNA editing is a post-transcriptional alteration of RNA sequences that is able to affect protein structure as well as RNA and protein expression. Adenosine-to-inosine (A-to-I) RNA editing is the most frequent and common post-transcriptional modification in human, where adenosine (A) deamination produces its conversion into inosine (I), which in turn is
Nigita G, Alaimo S, FERRO, Alfredo, Giugno R, PULVIRENTI, ALFREDO   +4 more
openaire   +3 more sources

Genetic variation and microRNA targeting of A-to-I RNA editing fine tune human tissue transcriptomes

Genome Biology, 2021
Background A-to-I RNA editing diversifies the transcriptome and has multiple downstream functional effects. Genetic variation contributes to RNA editing variability between individuals and has the potential to impact phenotypic variability.
Eddie Park, Yan Jiang, Lili Hao, Jingyi Hui, Yi Xing   +4 more
doaj   +1 more source

Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism [PDF]

, 2010
For a long time it has been assumed that the decay of RNA in eukaryotes is mainly carried out by exoribonucleases, which is in contrast to bacteria, where endoribonucleases are well documented to initiate RNA degradation.
Tomecki, Rafał, Dziembowski, Andrzej
core   +3 more sources

RNA Editing: An I for editing [PDF]

Current Biology, 1995
In vitro editing in mammalian nuclear extracts reveals adenosine-to-inosine conversions in glutamate receptor messenger RNAs.
openaire   +2 more sources

A-to-I RNA Editing in Cancer: From Evaluating the Editing Level to Exploring the Editing Effects [PDF]

Frontiers in Oncology, 2021
As an important regulatory mechanism at the posttranscriptional level in metazoans, adenosine deaminase acting on RNA (ADAR)-induced A-to-I RNA editing modification of double-stranded RNA has been widely detected and reported. Editing may lead to non-synonymous amino acid mutations, RNA secondary structure alterations, pre-mRNA processing changes, and ...
Heming Wang, Heming Wang, Heming Wang, Sinuo Chen, Sinuo Chen, Jiayi Wei, Jiayi Wei, Guangqi Song, Guangqi Song, Yicheng Zhao   +9 more
openaire   +3 more sources

An essential role of KREPB4 in RNA editing and structural integrity of the editosome in Trypanosoma brucei [PDF]

, 2007
RNA editing in the sleeping sickness parasite Trypanosoma brucei remodels mitochondrial transcripts by the addition and deletion of uridylates as specified by guide RNAs.
Schnaufer, Achim; id_orcid, Stuart, Kenneth, Ernst, Nancy Lewis, Fleck, Michele, Babbarwal, Vinod Kumar   +4 more
core   +1 more source

BreenMS/Developmental-RNA-editing: Spatiotemporal and genetic regulation of A-to-I editing throughout human brain development

, 2022
Code used to process the following manuscript: Posttranscriptional RNA modifications by adenosine-to-inosine (A-to-I) editing are abundant in the brain, yet elucidating functional sites remains challenging.
Michael S. Breen, PhD
core   +1 more source

The role of A-to-I RNA editing in cancer development [PDF]

Current Opinion in Genetics & Development, 2018
Adenosine-to-inosine (A-to-I) RNA editing is the most common type of post-transcriptional nucleotide modification in humans, which is catalyzed in ADAR enzymes. Recent genomic studies have revealed thousands of altered RNA editing events in various cancer tissues, leading to diverse functional consequences.
Xiaoyan, Xu, Yumeng, Wang, Han, Liang
openaire   +2 more sources

Alternative splicing and extensive RNA editing of human TPH2 transcripts. [PDF]

, 2010
Brain serotonin (5-HT) neurotransmission plays a key role in the regulation of mood and has been implicated in a variety of neuropsychiatric conditions. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of 5-HT.
Bondy, Brigitta, Bondy, B., Baghai Thomas C., Brigitta Bondy, Peter Zill, Zill, P., Schüle Cornelius, Hammer, P., Grohmann Maik, Büttner, A., Walther Maria, Priller, Josef, Hammer Paul, Baghai, Thomas C., Maik Grohmann, Wolfgang Eisenmenger, Baghai, T., Priller Josef, Josef Priller, Walther, D.J., Eisenmenger, Wolfgang, Bader, Michael, Zill, Peter, Paul Hammer, Hammer, Paul, Rupprecht Rainer, Büttner, Andreas, Michael Bader, Andreas Büttner, Diego J Walther, Cornelius Schüle, Paulmann, Nils, Zill Peter, Bader Michael, Eisenmenger, W., Schüle, Cornelius, Maria Walther, Rainer Rupprecht, Thomas C Baghai, Paulmann Nils, Schuele, C., Walther, Diego J., Rupprecht, R., Nils Paulmann, Baghai, T.C., Eisenmenger Wolfgang, Walther, Maria, Grohmann, M., Bondy Brigitta, Walther Diego J., Bader, M., Priller, J., Paulmann, N., Büttner Andreas, Walther, M., Grohmann, Maik, Rupprecht, Rainer, Schüle, C., Walther, D., Buettner, A.   +59 more
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C-to-U RNA Editing: A Site Directed RNA Editing Tool for Restoration of Genetic Code

, 2022
The restoration of genetic code by editing mutated genes is a potential method for the treatment of genetic diseases/disorders. Genetic disorders are caused by the point mutations of thymine (T) to cytidine (C) or guanosine (G) to adenine (A), for which ...
Sonali Bhakta, Toshifumi Tsukahara, Tsukahara, Toshifumi, Bhakta, Sonali   +3 more
core   +1 more source