Reduction of RNA A-to-I editing in Drosophila acclimated to heat shock
Kaohsiung Journal of Medical Sciences, 2013 Although an increasing number of RNA adenosine-to-inosine (A-to-I) editing sites are being discovered, how the editing frequencies of these sites are modulated to fine-tune protein function in adaptive responses is not well understood.
Joel Stocker +6 more
doaj +4 more sources
ADAR1 A-to-I RNA editing alters codon usage
bioRxiv, 2018 BackgroundFully grown mammalian oocytes and eggs are transcriptionally quiescent, and therefore have a unique RNA environment in which cellular processes depend on post-transcriptional regulation.
Pavla Brachova +5 more
semanticscholar +2 more sources
Expanding the proteome: A-to-I RNA editing provides an adaptive advantage. [PDF]
Proc Natl Acad Sci U S A, 2023 RNA editing refers to the post-transcriptional modification of RNA sequences. Diverse eukaryotes are capable of mRNA editing, most commonly through enzymatic deamination of adenosine-to-inosine (A-to-I) (1–3).
Lewis ZA.
europepmc +2 more sources
A-to-I RNA Editing: Recent News and Residual Mysteries [PDF]
Journal of Biological Chemistry, 2003 Adenosine to inosine modification in pre-mRNA, with inosine acting as guanosine during translation, was the most recent type of RNA editing to be discovered (1).
Stefan, Maas +2 more
openaire +3 more sources
The Many Roles of A-to-I RNA Editing in Animals: Functional or Adaptive?
Frontiers in Bioscience-Landmark, 2023 Metazoan adenosine-to-inosine (A-to-I) RNA editing is a highly conserved mechanism that diversifies the transcriptome by post-transcriptionally converting adenosine to inosine.
Dongwu Zhan +4 more
doaj +1 more source
L-GIREMI uncovers RNA editing sites in long-read RNA-seq
Genome Biology, 2023 Although long-read RNA-seq is increasingly applied to characterize full-length transcripts it can also enable detection of nucleotide variants, such as genetic mutations or RNA editing sites, which is significantly under-explored.
Zhiheng Liu +7 more
doaj +1 more source
REDIportal: millions of novel A-to-I RNA editing events from thousands of RNAseq experiments
Nucleic Acids Res., 2020 RNA editing is a relevant epitranscriptome phenomenon able to increase the transcriptome and proteome diversity of eukaryotic organisms. ADAR mediated RNA editing is widespread in humans in which millions of A-to-I changes modify thousands of primary ...
L. Mansi +9 more
semanticscholar +1 more source
A dual role of EZH2 in regulating A-to-I RNA editing and mRNA stability through ADAR. [PDF]
Nat CommunAdenosine-to-inosine (A-to-I) RNA editing, catalyzed by adenosine deaminases acting on RNA (ADARs), is a widespread modification in metazoans. Cumulative evidence has revealed the altered A-to-I editing profiles in cancers, but the underlying mechanism ...
Yi Y +26 more
europepmc +2 more sources
Uncovering Cis-Regulatory Elements Important for A-to-I RNA Editing in Fusarium graminearum
mBio, 2022 Adenosine-to-inosine (A-to-I) RNA editing independent of adenosine deaminase acting on RNA (ADAR) enzymes was discovered in fungi recently, and shown to be crucial for sexual reproduction. However, the underlying mechanism for editing is unknown.
Chanjing Feng +8 more
doaj +1 more source
Host A-to-I RNA editing signatures in intracellular bacterial and single-strand RNA viral infections
Frontiers in Immunology, 2023 BackgroundMicrobial infection is accompanied by remodeling of the host transcriptome. Involvement of A-to-I RNA editing has been reported during viral infection but remains to be elucidated during intracellular bacterial infections.ResultsHerein we ...
Zhi-Yuan Wei +30 more
doaj +1 more source