Results 71 to 80 of about 134,460,322 (302)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

RNA editing in kinetoplastids

, 2010
RNA editing in kinetoplastid protozoa is a post-transcriptional process of uridine insertion or deletion in mitochondrial mRNAs. The process involves two RNA species, the pre-edited mRNA and in most cases a trans-acting guide RNA (gRNA). Sequences within
Hajduk, Stephen, Torsten Ochsenreiter, Stephen Hajduk, Ochsenreiter, Torsten   +3 more
core   +1 more source

Table_4_Host A-to-I RNA editing signatures in intracellular bacterial and single-strand RNA viral infections.xlsx

, 2023
BackgroundMicrobial infection is accompanied by remodeling of the host transcriptome. Involvement of A-to-I RNA editing has been reported during viral infection but remains to be elucidated during intracellular bacterial infections.ResultsHerein we ...
Yu-Ning Li (12562204), Yan-Shuo Wen (15178717), Jian-Huan Chen (2833196), Zhi-Xin Wang (156984), Di Gao (501357), Yan-Shan Liu (11371530), Yun-Yun Jin (15178723), Zhi-Yuan Wei (10825668), Jia-Huan Li (11679433), Xu-Bin Pan (15178720), Shou-Yue Xia (12293144)   +10 more
core   +1 more source

ADAR1 is increased in prostate cancer progression and silencing reduces A-to-I editing and cell growth while enhancing apoptosis and adhesion

Scientific Reports
Adenosine deaminase acting on RNA 1 (ADAR1) catalyses adenosine-to-inosine (A-to-I) RNA editing and has emerged as a regulator of cell biology. Here, we investigate the expression and function of ADAR1 in prostate cancer using in vitro models and ...
Stefania Kalogera, Klaudia Detkiewicz, Lisbeth Verk, Irem Cemile Eroglu, Youssef Khaled Abdelhamid, Gjendine Voss, Margareta Persson, Martin Sjöström, Anders Bjartell, Yvonne Ceder   +9 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Table_5_Host A-to-I RNA editing signatures in intracellular bacterial and single-strand RNA viral infections.xlsx

, 2023
BackgroundMicrobial infection is accompanied by remodeling of the host transcriptome. Involvement of A-to-I RNA editing has been reported during viral infection but remains to be elucidated during intracellular bacterial infections.ResultsHerein we ...
Yu-Ning Li (12562204), Yan-Shuo Wen (15178717), Jian-Huan Chen (2833196), Zhi-Xin Wang (156984), Di Gao (501357), Yan-Shan Liu (11371530), Yun-Yun Jin (15178723), Zhi-Yuan Wei (10825668), Jia-Huan Li (11679433), Xu-Bin Pan (15178720), Shou-Yue Xia (12293144)   +10 more
core   +1 more source

A comprehensive study on cellular RNA editing activity in response to infections with different subtypes of influenza a viruses

BMC Genomics, 2018
Background RNA editing is an important mechanism that expands the diversity and complexity of genetic codes. The conversions of adenosine (A) to inosine (I) and cytosine (C) to uridine (U) are two prominent types of RNA editing in animals.
Yingying Cao, Ruiyuan Cao, Yaowei Huang, Hongxia Zhou, Yuanhua Liu, Xuan Li, Wu Zhong, Pei Hao   +7 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

PREPACT 2.0: Predicting C-to-U and U-to-C RNA Editing in Organelle Genome Sequences with Multiple References and Curated RNA Editing Annotation

, 2013
RNA editing is vast in some genetic systems, with up to thousands of targeted C-to-U and U-to-C substitutions in mitochondria and chloroplasts of certain plants. Efficient prognoses of RNA editing in organelle genomes will help to reveal overlooked cases
Henning Lenz, Volker Knoop
core   +1 more source

RNA editing in Parkinson’s disease: emerging mechanisms, translational potential, and current challenges

Frontiers in Neuroscience
Parkinson’s disease (PD) is a major neurodegenerative disorder characterized by progressive loss of dopaminergic neurons and accumulation of α-synuclein.
Shutong Liu, An Wu
doaj   +1 more source