Results 31 to 40 of about 8,523 (174)

ADAR RNA Modifications, the Epitranscriptome and Innate Immunity [PDF]

Trends in Biochemical Sciences, 2021
Modified bases act as marks on cellular RNAs so that they can be distinguished from foreign RNAs, reducing innate immune responses to endogenous RNA. In humans, mutations giving reduced levels of one base modification, adenosine-to-inosine deamination, cause a viral infection mimic syndrome, a congenital encephalitis with aberrant interferon induction.
Quin, Jaclyn, Sedmík, Jiří, Vukić, Dragana, Khan, Anzer, Keegan, Liam P., O’Connell, Mary A.   +5 more
openaire   +3 more sources

ADAR RNA editing below the backbone [PDF]

RNA, 2017
ADAR RNA editing enzymes (adenosine deaminases acting on RNA) that convert adenosine bases to inosines were first identified biochemically 30 years ago. Since then, studies on ADARs in genetic model organisms, and evolutionary comparisons between them, continue to reveal a surprising range of pleiotropic biological effects of ADARs. This review focuses
Liam Keegan, Anzer Khan, Dragana Vukic, Mary O'Connell   +3 more
openaire   +2 more sources

ADAR Editing Wobbles the MicroRNA World [PDF]

ACS Chemical Biology, 2007
Recent work reveals that adenosine-to-inosine editing occurs in a number of cellular microRNAs (miRNAs). Such editing is shown to diminish the expression of one miRNA and alter the target specificity of another. This changes our current views significantly by not only increasing the repertoire of miRNAs and their potential targets, but also providing ...
Asis K, Das, Gordon G, Carmichael
openaire   +2 more sources

Alterations in RNA editing in skeletal muscle following exercise training in individuals with Parkinson's disease.

PLoS ONE, 2023
Parkinson's Disease (PD) is the second most common neurodegenerative disease behind Alzheimer's Disease, currently affecting more than 10 million people worldwide and 1.5 times more males than females.
Heather Milliken Mercer, Aiswarya Mukundan Nair, Angela Ridgel, Helen Piontkivska   +3 more
doaj   +1 more source

Promoting RNA editing by ADAR attraction [PDF]

Genome Biology, 2017
Concentration is important and not only while driving; a new study indicates how an adjacent genomic element helps to increase the efficiency of a specific adenosine to inosine RNA editing reaction, by providing a means to increase the local concentration of the RNA editing enzyme ADAR.
Miri Danan-Gotthold, Erez Y. Levanon
openaire   +3 more sources

Extending adamic adar for cold-start problem in link prediction based on network metrics

IJAIN (International Journal of Advances in Intelligent Informatics), 2022
The cold-start problem is a condition for a new node to join a network with no available information or an isolated node. Most studies use topological network information with the Triadic Closure principles to predict links in future networks.
Herman Yuliansyah, Zulaiha Ali Othman, Azuraliza Abu Bakar   +2 more
doaj   +1 more source

Changes in ADAR RNA editing patterns in CMV and ZIKV congenital infections

BMC Genomics, 2023
Background RNA editing is a process that increases transcriptome diversity, often through Adenosine Deaminases Acting on RNA (ADARs) that catalyze the deamination of adenosine to inosine.
Benjamin Wales-McGrath, Heather Mercer, Helen Piontkivska   +2 more
doaj   +1 more source

ADAR Regulates RNA Editing, Transcript Stability, and Gene Expression

Cell Reports, 2013
Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine, which is then recognized as guanosine. To study the role of ADAR proteins in RNA editing and gene regulation, we sequenced and compared the DNA and RNA of human B cells.
Isabel X. Wang, Elizabeth So, James L. Devlin, Yue Zhao, Ming Wu, Vivian G. Cheung   +5 more
doaj   +1 more source

Unveiling RNA Editing by ADAR and APOBEC Protein Gene Families

Frontiers in Bioscience-Landmark
RNA editing is a crucial post-transcriptional modification that alters the transcriptome and proteome and affects many cellular processes, including splicing, microRNA specificity, stability of RNA molecules, and protein structure.
Alexander Modestov, Anton Buzdin, Maria Suntsova   +2 more
doaj   +1 more source

Shountrade, Adare

, 1937
Creagán na hOla Graveyard in the Parish of Adare / Murphy, Kitty -- How Creagán na hOla Got Its Name / Murphy, Kitty -- Creagán na hOla / Hickey, Mary -- Desmonds' Castle, Adare / Hickey, Mary -- St Brigid's Well / Fennell, Brigid -- My School District - Shountrade / Fennell, Brigid -- Seanbheann, Rour, Adare / Monckton, Mary -- Old Relic of the Fenian
Shountrade, Adare, Fhloinn, Máire, Murphy, Kitty, Hickey, Mary, Fennell, Brigid, Monckton, Mary, Monckton, Kathryn, Kinevane, Annie, Bourke, Kitty, Dillon, Chrissie, Conway, Nora, Browne, Nora, Fennell, Thomas, Bourke, Mary, Bourke, Stephen, Nash, Peggy, Mahon, Thomas Mc   +16 more
openaire   +1 more source