Targeting ADAR stability: a novel approach to combat glioblastoma [PDF]
Frontiers in OncologyBackgroundAdenine deaminase (ADAR) is a key RNA editing enzyme that plays an important role in the initiation and progression of cancer. However, the mechanisms regulating its protein stability and its function in glioblastoma (GBM) remain unclear ...
Qin Fei +4 more
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SARS-CoV-2-induced dysregulation in ADAR editing patterns persists post viral clearance in individuals with mild COVID-19 [PDF]
Frontiers in Cellular and Infection MicrobiologyIntroductionInnate immune response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection activates multiple interferon stimulated genes (ISGs), including ADAR1 p150 isoform, which edits adenosine (A) residues within double stranded ...
Aiswarya Mukundan Nair +4 more
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ADAR-mediated RNA editing in CNS disorders: from pathogenic mechanisms to therapeutic opportunities [PDF]
Cellular & Molecular Biology LettersThe adenosine deaminases acting on RNA (ADAR) family of enzymes (ADAR1 and ADAR2) catalyze adenosine-to-inosine (A-to-I) RNA editing. This post-transcriptional change is remarkably prevalent in the central nervous system (CNS).
Fushuang Zheng +5 more
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ADAR Regulates RNA Editing, Transcript Stability, and Gene Expression [PDF]
Cell Reports, 2013 Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine, which is then recognized as guanosine. To study the role of ADAR proteins in RNA editing and gene regulation, we sequenced and compared the DNA and RNA of human B cells.
Isabel X. Wang +5 more
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The context-dependent role of the dsRNA response in linking A-to-I editing and ADAR to normal hematopoiesis and leukemia [PDF]
Frontiers in Cell and Developmental BiologyAdenosine-to-inosine (A-to-I) RNA editing, catalyzed by adenosine deaminase acting on RNA (ADAR), contributes to cellular RNA homeostasis. By recoding protein, inducing alternative splicing and regulating non-coding RNAs, ADAR-mediated editing influences
Xiaowei Li, Jiayue Xu, Jia Yu
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Editome profiling and cross-cohort validation reveal A-to-I RNA editing dysregulation in the hippocampus and prefrontal cortex of sepsis patients [PDF]
Frontiers in PsychiatryIntroductionSepsis is a severe systemic inflammatory response to infection, potentially resulting in serious neurological complications. Adenosine-to-inosine (A-to-I) RNA editing is a critical epitranscriptomic process, yet its clinical involvement in ...
Jie Shen +7 more
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Dysregulation of SIRT1, polyamines and miRNA editing in cancer and aging [PDF]
Amino AcidsInterest in RNA editing has emerged in molecular medicine due to its widespread dysregulation and therapeutic potential. Its regulatory mechanisms in governing non-coding RNAs, especially microRNAs (miRNAs) remain largely unresolved. Emerging evidence in
Miora Bruna Marielle Ramamonjiharisoa +1 more
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Knockdown of RNA editing proteins reshapes the HepaRG transcriptome and pharmacogene expression [PDF]
Scientific ReportsThe RNA-editing proteins ADAR and ADARB1 regulate gene expression through both editing-dependent and editing-independent mechanisms. RNA-Seq analysis of HepaRG cells after knocking down (KD) either protein caused widespread transcriptomic changes ...
Joseph M Collins +3 more
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Physiological roles of Drosophila ADAR and modifiers [PDF]
, 2013 ADAR (Adenosine Deaminases acting on RNA) family proteins are double-strand RNA binding proteins that deaminate specific adenosines into inosines. This A-to-I conversion is called A-to-I RNA editing and is well conserved in the animal kingdom from ...
Li, Xianghua
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Astrazon Black MBL boyasının yenilikçi bir adsorbent ile giderimi: Taguchi metodu ile işletme parametrelerinin optimizasyonu [PDF]
, 2021 Various dyes are used in the textile industry. Azo dyes, stable and toxic, constitute the majority of these dyes. In this study, the removal of Astrazon Black MBL belonging to azo group with an innovative adsorbent was investigated.
Adar, Elanur
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